Enables neuropeptide receptor activity. Involved in several processes, including behavioral response to ethanol; social behavior; and thermotaxis. Located in axon; plasma membrane; and somatodendritic compartment. Expressed in excretory system; neurons; pharyngeal muscle cell; and preanal ganglion. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in hypertension. Is an ortholog of human PRLHR (prolactin releasing hormone receptor).
The protein encoded by this gene is a zinc finger transcriptional repressor and may be part of the NuRD histone deacetylase complex (HDAC). Defects in this gene are a cause of Townes-Brocks syndrome (TBS) as well as bronchio-oto-renal syndrome (BOR). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]