csp-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables caspase binding activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; and zymogen binding activity. Involved in positive regulation of brood size; positive regulation of fertilization; and regulation of apoptotic process. Part of protease inhibitor complex. Expressed in germ line. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; carcinoma (multiple); chronic myeloid leukemia; and ductal carcinoma in situ. Is an ortholog of human CASP6 (caspase 6).
csp-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables cysteine-type endopeptidase activity. Involved in several processes, including negative regulation of cellular response to manganese ion; positive regulation of apoptotic process; and positive regulation of cellular response to gamma radiation. Located in germ cell nucleus. Expressed in germ line. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; carcinoma (multiple); gastrointestinal system cancer (multiple); and prostate disease (multiple). Is an ortholog of several human genes including CASP3 (caspase 3); CASP6 (caspase 6); and CASP7 (caspase 7).
ced-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables cysteine-type endopeptidase activator activity involved in apoptotic process; cysteine-type endopeptidase activity involved in execution phase of apoptosis; and identical protein binding activity. Involved in several processes, including apoptotic process; protein metabolic process; and regulation of developmental process. Located in several cellular components, including neuronal cell body; perinuclear region of cytoplasm; and presynapse. Part of caspase complex. Expressed in several structures, including ABaraapapaa; NSM; apoptotic cell; germ line; and oocyte. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; carcinoma (multiple); gastrointestinal system cancer (multiple); and prostate disease (multiple). Is an ortholog of human CASP3 (caspase 3); CASP6 (caspase 6); and CASP7 (caspase 7).