Enables tyrosine 3-monooxygenase activity. Involved in several processes, including cellular response to amphetamine; dopamine biosynthetic process from tyrosine; and male mating behavior. Located in axon. Expressed in dopaminergic neurons; socket cell; and in male. Used to study several diseases, including amphetamine abuse; cocaine abuse; and nicotine dependence. Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; artery disease (multiple); and obesity. Is an ortholog of human TH (tyrosine hydroxylase).
Is affected by several genes including clk-1; tph-1; and cat-2 based on microarray and RNA-seq studies. Is affected by resveratrol based on microarray studies.
Is affected by several genes including rrf-3; cep-1; and cat-2 based on RNA-seq studies. Is affected by Alovudine; stavudine; and Tamoxifen based on RNA-seq studies.
Enriched in male based on RNA-seq studies. Is affected by several genes including clk-1; tph-1; and cat-2 based on tiling array; microarray; and RNA-seq studies.
Is affected by several genes including tph-1; pgl-1; and cat-2 based on RNA-seq studies. Is affected by multi-walled carbon nanotube based on RNA-seq studies.
Is affected by several genes including eat-2; tph-1; and cat-2 based on tiling array and RNA-seq studies. Is affected by Rifampin; allantoin; and Sirolimus based on RNA-seq and microarray studies.