pal-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell fate commitment; embryonic pattern specification; and positive regulation of DNA-templated transcription. Located in condensed nuclear chromosome. Expressed in several structures, including ABprpppppaa; enteric muscle; epithelial cell; oocyte; and tail spike. Human ortholog(s) of this gene implicated in Barrett's esophagus. Is an ortholog of human CDX1 (caudal type homeobox 1) and CDX2 (caudal type homeobox 2).
ceh-40 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in animal organ development; neuron development; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in dopaminergic neurons.
ceh-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in transdifferentiation. Acts upstream of with a positive effect on multicellular organismal-level water homeostasis. Located in cytosol and nucleus. Expressed in body wall musculature;
hyp7 syncytium; intestine; and neurons. Human ortholog(s) of this gene implicated in X-linked deafness 2. Is an ortholog of human POU3F1 (POU class 3 homeobox 1); POU3F3 (POU class 3 homeobox 3); and POU3F4 (POU class 3 homeobox 4).
psa-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables transcription coactivator binding activity. Involved in regulation of asymmetric cell division. Located in nucleus. Expressed in several structures, including TL.aa; TL.pa; TR.aa; TR.pa; and hypodermal cell.
ceh-10 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including egg-laying behavior; generation of neurons; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in ABalapppaa; CAN; head neurons; seam cell; and somatic nervous system. Human ortholog(s) of this gene implicated in eye disease (multiple). Is an ortholog of human VSX2 (visual system homeobox 2).
ceh-41 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in body wall musculature; neurons; and somatic nervous system.
ceh-60 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in dopaminergic neuron differentiation and regulation of transcription by RNA polymerase II. Acts upstream of or within lipid homeostasis. Part of chromatin. Expressed in amphid neurons and sensory neurons.
ceh-21 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed widely.
ceh-32 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in post-embryonic animal morphogenesis. Located in nucleus. Expressed in several structures, including anterior hypodermis; gonadal sheath cell; head ganglion; pharyngeal neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including holoprosencephaly 2; optic disc anomalies with retinal and/or macular dystrophy; and renal Wilms' tumor. Is an ortholog of human SIX3 (SIX homeobox 3) and SIX6 (SIX homeobox 6).
ceh-20 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables cis-regulatory region sequence-specific DNA binding activity and transcription coactivator binding activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell differentiation; positive regulation of mesodermal cell fate specification; and regulation of asymmetric cell division. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Expressed in several structures, including P1.p; P2.p; neurons; seam cell; and somatic nervous system. Human ortholog(s) of this gene implicated in congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay; esophagus squamous cell carcinoma; and glaucoma. Is an ortholog of human PBX4 (PBX homeobox 4).
ceh-51 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in mesodermal cell fate specification; muscle cell fate specification; and pharyngeal muscle development. Located in nucleus. Expressed in several structures, including MSaa; MSap; MSp; MSpa; and MSpp.
ceh-14 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in neuron development; positive regulation of transcription by RNA polymerase II; and thermosensory behavior. Located in nucleus. Expressed in several structures, including hypodermal cell; neurons; somatic nervous system; spermatheca; and tail. Human ortholog(s) of this gene implicated in panhypopituitarism. Is an ortholog of human LHX3 (LIM homeobox 3).
ceh-39 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and primary sex determination. Located in condensed nuclear chromosome and germ cell nucleus. Expressed in body wall musculature; germ line; gonad; neurons; and ventral nerve cord.
ceh-100 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in brain development; neuron differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed widely.
ceh-49 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in coelomocyte; head muscle; head neurons; intestine; and somatic nervous system.
ceh-83 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in hypodermis; intestine; and vulva.
sra-11 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable olfactory receptor activity. Involved in detection of chemical stimulus involved in sensory perception and olfactory learning. Predicted to be located in membrane. Expressed in VC neuron; interneuron; pharyngeal neurons; and ventral ganglion.
ceh-37 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables DNA binding activity, bending and double-stranded telomeric DNA binding activity. Involved in neuron fate specification; olfactory behavior; and regulation of transcription by RNA polymerase II. Located in chromosome, telomeric region. Expressed in several structures, including ABarpaap; dorsal nerve cord; excretory cell; head muscle; and head neurons. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 7 and cone-rod dystrophy 2. Is an ortholog of human CRX (cone-rod homeobox).
ceh-87 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in central nervous system development; neuron differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in head neurons; rectal gland cell; and tail neurons.
ceh-48 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in head; neurons; spermathecal-uterine junction; ventral nerve cord; and vulva. Is an ortholog of human ONECUT1 (one cut homeobox 1); ONECUT2 (one cut homeobox 2); and ONECUT3 (one cut homeobox 3).
ceh-99 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in brain development; neuron differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.
ceh-36 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in neuron fate specification; positive regulation of transcription by RNA polymerase II; and sensory perception of chemical stimulus. Located in nucleus. Expressed in ABaraappa; ABaraappaa; amphid neurons; and head neurons. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 5. Is an ortholog of human ARGFX (arginine-fifty homeobox); DPRX (divergent-paired related homeobox); and NOBOX (NOBOX oogenesis homeobox).
ceh-16 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables sequence-specific DNA binding activity. Involved in several processes, including embryonic body morphogenesis; epidermal cell fate specification; and regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including ABarpa; AIZ;
hyp5; retrovesicular ganglion neurons; and seam cell. Human ortholog(s) of this gene implicated in Parkinson's disease and autistic disorder. Is an ortholog of human EN1 (engrailed homeobox 1) and EN2 (engrailed homeobox 2).
ceh-18 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; gamete generation; and negative regulation of oocyte maturation. Located in nucleus. Expressed in body wall musculature; gonad; neurons; non-striated muscle; and somatic nervous system. Is an ortholog of human POU2F2 (POU class 2 homeobox 2) and POU2F3 (POU class 2 homeobox 3).
ceh-34 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables sequence-specific DNA binding activity. Involved in mesodermal cell fate specification; positive regulation of apoptotic process involved in development; and regulation of DNA-templated transcription. Located in nucleus. Expressed in body wall musculature; corpus; head; male sex myoblast; and pharyngeal neurons. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant nonsyndromic deafness 23; carcinoma (multiple); and renal Wilms' tumor. Is an ortholog of human SIX1 (SIX homeobox 1) and SIX2 (SIX homeobox 2).
ceh-89 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in neurons. Is an ortholog of human HOPX (HOP homeobox).
ceh-9 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in head muscle; head neurons; intestine; lumbar neurons; and somatic nervous system.
ceh-12 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable sequence-specific double-stranded DNA binding activity. Predicted to be involved in central nervous system development and neuron projection morphogenesis. Predicted to be located in nucleus. Expressed in VB neuron; ventral nerve cord; and vulval muscle. Human ortholog(s) of this gene implicated in Currarino syndrome. Is an ortholog of human MNX1 (motor neuron and pancreas homeobox 1).
ceh-27 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in I6 neuron; intestine; nerve ring; and nerve ring neurons.
ceh-57 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in amphid neurons; intestine; neuroblasts; and somatic nervous system.
ceh-22 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables sequence-specific DNA binding activity. Involved in several processes, including gonad morphogenesis; pharyngeal muscle development; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including G1; gonad; neurons; pharyngeal cell; and ventral nerve cord. Used to study cancer. Is an ortholog of human NKX2-2 (NK2 homeobox 2).
Y71G12B.10 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable hydroxymethylglutaryl-CoA lyase activity. Predicted to be involved in ketone body biosynthetic process and leucine catabolic process. Human ortholog(s) of this gene implicated in amino acid metabolic disorder. Is an ortholog of human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase) and HMGCLL1 (3-hydroxy-3-methylglutaryl-CoA lyase like 1).
vab-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including male anatomical structure morphogenesis; negative regulation of distal tip cell migration; and positive regulation of glial cell differentiation. Located in cytoplasm and nucleus. Expressed in several structures, including Y.p; distal tip cell; head muscle; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including bilateral optic nerve hypoplasia; eye disease (multiple); and glucose intolerance. Is an ortholog of human PAX6 (paired box 6).
ceh-30 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of apoptotic process; nervous system development; and sex differentiation. Located in nucleus. Expressed in embryonic cell and neurons. Human ortholog(s) of this gene implicated in colorectal cancer; oral squamous cell carcinoma; and stomach cancer. Is an ortholog of human BARHL2 (BarH like homeobox 2).
aps-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in vesicle-mediated transport. Predicted to be located in intracellular membrane-bounded organelle. Is an ortholog of human AP3S1 (adaptor related protein complex 3 subunit sigma 1) and AP3S2 (adaptor related protein complex 3 subunit sigma 2).
ceh-58 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in neurons and somatic nervous system.
ceh-91 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA binding activity and chromatin binding activity. Predicted to be involved in chromatin organization and regulation of DNA-templated transcription. Predicted to be located in nucleus. Expressed in dorsal nerve cord; head muscle; and ventral nerve cord.
htp-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in homologous chromosome pairing at meiosis and meiotic DNA double-strand break formation. Located in lateral element. Part of chromatin. Expressed in Z2; Z3; embryonic cell; germ line; and neurons.
ceh-45 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in I1L; I1R; MI neuron; pharynx; and spermatheca. Is an ortholog of human GSC (goosecoid homeobox).
ceh-8 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in lateral ganglion and somatic gonad precursor. Human ortholog(s) of this gene implicated in isolated microphthalmia 3 and retinal degeneration (multiple). Is an ortholog of human RAX2 (retina and anterior neural fold homeobox 2).
ppk-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 1-phosphatidylinositol-3-phosphate 5-kinase activity and phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process. Located in axon; cytoplasm; and neuronal cell body. Expressed in hypodermis; non-striated muscle; somatic nervous system; and tail neurons. Human ortholog(s) of this gene implicated in Fleck corneal dystrophy. Is an ortholog of human PIKFYVE (phosphoinositide kinase, FYVE-type zinc finger containing).
ceh-93 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in ADLL; ADLR; and seam cell.
csp-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables caspase binding activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; and zymogen binding activity. Involved in positive regulation of behavior; positive regulation of embryonic development; and regulation of apoptotic process. Located in cytoplasm. Expressed in several structures, including germ line.
ehn-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable metal ion binding activity. Involved in gonad development and positive regulation of gene expression. Located in nucleus. Expressed in Z1; Z4; and somatic gonad precursor.
ZK1098.3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 3'-5' exonuclease activity. Predicted to be involved in nucleobase-containing compound metabolic process and regulation of macromolecule metabolic process. Predicted to be located in cytoplasm and nucleus. Is an ortholog of human EXD3 (exonuclease 3'-5' domain containing 3).
R10E4.9 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 3-hydroxyacyl-CoA dehydratase activity. Predicted to be involved in fatty acid elongation; sphingolipid biosynthetic process; and very long-chain fatty acid biosynthetic process. Located in plasma membrane. Is an ortholog of human HACD3 (3-hydroxyacyl-CoA dehydratase 3).
gpd-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity. Predicted to be involved in glycolytic process. Predicted to be located in cytosol. Expressed in several structures, including gonad; intestine; and pharynx. Human ortholog(s) of this gene implicated in Alzheimer's disease and lymphangioleiomyomatosis. Is an ortholog of human GAPDH (glyceraldehyde-3-phosphate dehydrogenase).
apd-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in intracellular transport and synaptic vesicle membrane organization. Predicted to be located in endosome membrane; presynaptic endosome; and terminal bouton. Predicted to be part of AP-3 adaptor complex. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome. Is an ortholog of human AP3D1 (adaptor related protein complex 3 subunit delta 1).
ceh-28 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II and regulation of neuron differentiation. Part of chromatin. Expressed in several structures, including ABalaappa; ABalaappaa; ABalaappap; ABalapapa; and M4 neuron. Human ortholog(s) of this gene implicated in several diseases, including aortic valve disease 2; congenital heart disease (multiple); and heart conduction disease (multiple). Is an ortholog of human NKX2-5 (NK2 homeobox 5).
ceh-63 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in ganglia; head; tail; uterus; and in male.
apb-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in embryo development and lysosome organization. Predicted to be located in clathrin-coated vesicle membrane. Predicted to be part of AP-3 adaptor complex. Expressed in motor neurons. Human ortholog(s) of this gene implicated in several diseases, including Hermansky-Pudlak syndrome 2; developmental and epileptic encephalopathy 48; and pulmonary fibrosis. Is an ortholog of human AP3B2 (adaptor related protein complex 3 subunit beta 2).
ceh-74 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Expressed in neurons and somatic nervous system.
ceh-33 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Expressed in head and head muscle. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant nonsyndromic deafness 23; carcinoma (multiple); and optic disc anomalies with retinal and/or macular dystrophy. Is an ortholog of human SIX1 (SIX homeobox 1); SIX2 (SIX homeobox 2); and SIX6 (SIX homeobox 6).
apm-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in lipid storage and lysosome organization. Predicted to be located in cytoplasmic vesicle. Predicted to be part of clathrin adaptor complex. Expressed in muscle cell; pharynx; spermatheca; and vulva. Is an ortholog of human AP3M1 (adaptor related protein complex 3 subunit mu 1).
gck-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in epithelial tube morphogenesis; hyperosmotic response; and multicellular organismal-level water homeostasis. Acts upstream of with a positive effect on positive regulation of gene expression. Located in cytoplasm. Expressed in body wall musculature; excretory system; hypodermis; oocyte; and spermatheca. Is an ortholog of human OXSR1 (oxidative stress responsive kinase 1) and STK39 (serine/threonine kinase 39).
dyf-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in several processes, including chemosensory behavior; cilium assembly; and response to alkaline pH. Located in axon; dendrite; and neuronal cell body. Expressed in neurons. Is an ortholog of human CLUAP1 (clusterin associated protein 1).
piki-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in several processes, including phagosome maturation involved in apoptotic cell clearance; phosphatidylinositol-3-phosphate biosynthetic process; and positive regulation of phagocytosis, engulfment. Located in early phagosome and pseudopodium. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is an ortholog of human PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha) and PIK3C2B (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta).
mog-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in feminization of hermaphroditic germ-line and meiotic cell cycle. Located in nucleus. Expressed in germ line. Is an ortholog of human CWC25 (CWC25 spliceosome associated protein homolog).
eif-3.C [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable translation initiation factor binding activity. Predicted to contribute to translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 3 complex. Is an ortholog of human EIF3C (eukaryotic translation initiation factor 3 subunit C) and EIF3CL (eukaryotic translation initiation factor 3 subunit C like).
atx-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables cysteine-type deubiquitinase activity. Involved in chemical synaptic transmission. Located in cytoplasm and nucleus. Expressed in coelomocyte; head; somatic nervous system; and tail neurons. Used to study Machado-Joseph disease. Human ortholog(s) of this gene implicated in Machado-Joseph disease. Is an ortholog of human ATXN3 (ataxin 3) and ATXN3L (ataxin 3 like).
C05C10.3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable succinyl-CoA:3-oxo-acid CoA-transferase activity. Predicted to be involved in cellular ketone body metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder. Is an ortholog of human OXCT1 (3-oxoacid CoA-transferase 1) and OXCT2 (3-oxoacid CoA-transferase 2).
H43I07.1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in regulation of lipid metabolic process. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 3 and optic atrophy 3. Is an ortholog of human OPA3 (outer mitochondrial membrane lipid metabolism regulator OPA3).
set-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable methyltransferase activity. Predicted to be involved in methylation. Expressed in AB; Psub1; hypodermis; and intestine. Is an ortholog of human SMYD4 (SET and MYND domain containing 4).
eif-3.K [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA binding activity and ribosome binding activity. Predicted to contribute to translation initiation factor activity. Involved in positive regulation of apoptotic process. Located in cytoplasm. Expressed in several structures, including embryonic cell and germ line. Is an ortholog of human EIF3K (eukaryotic translation initiation factor 3 subunit K).
cpb-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable mRNA 3'-UTR binding activity; ribosome binding activity; and translation regulator activity, nucleic acid binding. Predicted to be involved in negative regulation of cytoplasmic translation. Predicted to be located in several cellular components, including neuron projection; nucleus; and synapse. Predicted to be part of messenger ribonucleoprotein complex. Expressed in PVDL; PVDR; and germ line. Human ortholog(s) of this gene implicated in liver cirrhosis. Is an ortholog of human CPEB1 (cytoplasmic polyadenylation element binding protein 1).
arx-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation. Predicted to be located in actin cytoskeleton and cytoplasm. Predicted to be part of Arp2/3 protein complex. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); immunodeficiency 71; and myelodysplastic syndrome. Is an ortholog of human ARPC1A (actin related protein 2/3 complex subunit 1A) and ARPC1B (actin related protein 2/3 complex subunit 1B).
ech-8 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 3-hydroxyacyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be located in peroxisome. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 3. Is an ortholog of human EHHADH (enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase).
atad-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATP binding activity and ATP hydrolysis activity. Involved in mitochondrion organization. Located in mitochondrion. Is an ortholog of human ATAD3A (ATPase family AAA domain containing 3A) and ATAD3B (ATPase family AAA domain containing 3B).
ech-9 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 3-hydroxyacyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be located in peroxisome. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 3. Is an ortholog of human EHHADH (enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase).
B0250.5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 3-hydroxyisobutyrate dehydrogenase activity. Predicted to be involved in valine catabolic process. Predicted to be located in mitochondrion. Is an ortholog of human HIBADH (3-hydroxyisobutyrate dehydrogenase).
ctc-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable electron transfer activity. Predicted to contribute to cytochrome-c oxidase activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrial inner membrane.
ceh-38 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in several structures, including body wall musculature; excretory cell; intestine; neurons; and somatic nervous system.
eif-3.D [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 3 complex. Expressed in pharynx. Is an ortholog of human EIF3D (eukaryotic translation initiation factor 3 subunit D).
Y50E8A.6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity. Predicted to be involved in glycerol-3-phosphate metabolic process. Predicted to be located in mitochondrion. Predicted to be part of glycerol-3-phosphate dehydrogenase complex. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is an ortholog of human GPD2 (glycerol-3-phosphate dehydrogenase 2).
cogc-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in gonad morphogenesis and regulation of cell migration. Located in Golgi apparatus and endoplasmic reticulum. Expressed in intestine; pharynx; seam cell; and vulva. Is an ortholog of human COG3 (component of oligomeric golgi complex 3).
ceh-44 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in head muscle; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including developmental and epileptic encephalopathy 67; gastrointestinal system cancer (multiple); and insulinoma. Is an ortholog of human CUX2 (cut like homeobox 2).
daz-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable mRNA 3'-UTR binding activity and translation activator activity. Predicted to be involved in 3'-UTR-mediated mRNA stabilization and positive regulation of translational initiation. Located in cytoplasm. Expressed in germ line; gonad; and in male. Is an ortholog of several human genes including DAZ1 (deleted in azoospermia 1); DAZ2 (deleted in azoospermia 2); and DAZ3 (deleted in azoospermia 3).
M02B7.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 3'-5'-RNA exonuclease activity. Predicted to be involved in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in cytoplasm. Is an ortholog of human ERI3 (ERI1 exoribonuclease family member 3).
mtm-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables inositol bisphosphate phosphatase activity and phosphatidylinositol phosphate phosphatase activity. Involved in several processes, including determination of adult lifespan; positive regulation of autophagosome maturation; and regulation of endocytosis. Located in cytoplasm. Expressed in body wall musculature and head neurons. Is an ortholog of human MTMR3 (myotubularin related protein 3).
ser-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables octopamine receptor activity. Involved in octopamine or tyramine signaling pathway. Predicted to be located in dendrite. Expressed in several structures, including ASH; SIA; head muscle; hermaphrodite gonad; and lumbar ganglion.
ugt-26 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1) and UGT3A2 (UDP glycosyltransferase family 3 member A2).
ugt-27 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1) and UGT3A2 (UDP glycosyltransferase family 3 member A2).
ugt-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1) and UGT3A2 (UDP glycosyltransferase family 3 member A2).
ugt-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1) and UGT3A2 (UDP glycosyltransferase family 3 member A2).
C46H11.3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation and cell migration. Predicted to be located in cytoplasm. Predicted to be part of Arp2/3 protein complex. Human ortholog(s) of this gene implicated in lung squamous cell carcinoma. Is an ortholog of human ARPC5 (actin related protein 2/3 complex subunit 5) and ARPC5L (actin related protein 2/3 complex subunit 5 like).
hmgs-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable hydroxymethylglutaryl-CoA synthase activity. Predicted to be involved in acetyl-CoA metabolic process and farnesyl diphosphate biosynthetic process, mevalonate pathway. Human ortholog(s) of this gene implicated in HMG-CoA synthase 2 deficiency and hepatocellular carcinoma. Is an ortholog of human HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2).
suf-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable mRNA binding activity. Predicted to be involved in RNA 3'-end processing. Predicted to be located in nucleus. Is an ortholog of human CSTF3 (cleavage stimulation factor subunit 3).
ugt-12 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1) and UGT3A2 (UDP glycosyltransferase family 3 member A2).
ugt-19 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1) and UGT3A2 (UDP glycosyltransferase family 3 member A2).
ugt-21 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1) and UGT3A2 (UDP glycosyltransferase family 3 member A2).
ugt-24 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1) and UGT3A2 (UDP glycosyltransferase family 3 member A2).
ugt-28 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1) and UGT3A2 (UDP glycosyltransferase family 3 member A2).
ugt-31 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1) and UGT3A2 (UDP glycosyltransferase family 3 member A2).
ugt-47 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1) and UGT3A2 (UDP glycosyltransferase family 3 member A2).
ugt-67 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1) and UGT3A2 (UDP glycosyltransferase family 3 member A2).
ugt-15 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1) and UGT3A2 (UDP glycosyltransferase family 3 member A2).
ugt-22 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1) and UGT3A2 (UDP glycosyltransferase family 3 member A2).
ugt-33 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1) and UGT3A2 (UDP glycosyltransferase family 3 member A2).
ugt-45 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1) and UGT3A2 (UDP glycosyltransferase family 3 member A2).
ugt-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1) and UGT3A2 (UDP glycosyltransferase family 3 member A2).
ceh-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in brain development; neuron differentiation; and regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in neurons; pharynx; somatic nervous system; and vulva. Human ortholog(s) of this gene implicated in carcinoma (multiple) and stomach cancer. Is an ortholog of human EMX1 (empty spiracles homeobox 1).
ugt-18 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1) and UGT3A2 (UDP glycosyltransferase family 3 member A2).
ugt-41 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1) and UGT3A2 (UDP glycosyltransferase family 3 member A2).
ugt-43 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1) and UGT3A2 (UDP glycosyltransferase family 3 member A2).
ugt-48 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1) and UGT3A2 (UDP glycosyltransferase family 3 member A2).
ugt-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1) and UGT3A2 (UDP glycosyltransferase family 3 member A2).
ric-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables protein folding chaperone. Involved in several processes, including cholinergic synaptic transmission; positive regulation of cholinergic synaptic transmission; and protein localization to cell surface. Located in intracellular membrane-bounded organelle; neuron projection; and neuronal cell body. Expressed in body wall musculature; neurons; and pharyngeal muscle cell. Is an ortholog of human RIC3 (RIC3 acetylcholine receptor chaperone).
hach-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 3-hydroxyisobutyryl-CoA hydrolase activity. Predicted to be involved in valine catabolic process. Predicted to be located in mitochondrion. Is an ortholog of human HIBCH (3-hydroxyisobutyryl-CoA hydrolase).
ugt-20 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1) and UGT3A2 (UDP glycosyltransferase family 3 member A2).
ugt-30 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1) and UGT3A2 (UDP glycosyltransferase family 3 member A2).
ugt-35 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1) and UGT3A2 (UDP glycosyltransferase family 3 member A2).
ooc-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable chloride channel activity. Involved in embryo development; establishment of mitotic spindle orientation; and protein localization. Located in endoplasmic reticulum. Expressed in P0.
gpdh-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glycerol-3-phosphate dehydrogenase (quinone) activity and glycerol-3-phosphate dehydrogenase [NAD(P)+] activity. Involved in intracellular accumulation of glycerol. Predicted to be located in cytosol. Predicted to be part of glycerol-3-phosphate dehydrogenase complex. Expressed in excretory cell and hypodermis. Human ortholog(s) of this gene implicated in Brugada syndrome 2. Is an ortholog of human GPD1 (glycerol-3-phosphate dehydrogenase 1) and GPD1L (glycerol-3-phosphate dehydrogenase 1 like).
pbs-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in proteasomal protein catabolic process. Predicted to be located in nucleus. Predicted to be part of proteasome core complex, beta-subunit complex. Is an ortholog of human PSMB3 (proteasome 20S subunit beta 3).
Y37E11AM.3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 3-dehydrosphinganine reductase activity. Predicted to be involved in 3-keto-sphinganine metabolic process and sphingolipid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis et progressiva 4 and follicular lymphoma. Is an ortholog of human KDSR (3-ketodihydrosphingosine reductase).
atg-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable Atg8-family ligase activity. Involved in macroautophagy. Predicted to be located in cytosol and phagophore assembly site. Is an ortholog of human ATG3 (autophagy related 3).
csn-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in establishment of mitotic spindle localization; mitotic cytokinesis; and ubiquitin-dependent protein catabolic process. Part of COP9 signalosome. Is an ortholog of human COPS3 (COP9 signalosome subunit 3).
dmd-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including nematode male tail tip morphogenesis; neuron differentiation; and regulation of reproductive process. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in neuronal cell body. Expressed in several structures, including PHC; epithelial cell; gonad; ray neuron type A; and tail hypodermis. Is an ortholog of human DMRTB1 (DMRT like family B with proline rich C-terminal 1).
gld-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables polynucleotide adenylyltransferase activator activity and protein domain specific binding activity. Involved in several processes, including developmental process involved in reproduction; positive regulation of meiotic nuclear division; and vulval development. Located in P granule. Part of RNA-directed RNA polymerase complex. Expressed in germ line and in male.
eif-3.G [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables mRNA 5'-UTR binding activity. Involved in positive regulation of translation. Located in cytoplasm. Expressed in germ line and somatic cell. Is an ortholog of human EIF3G (eukaryotic translation initiation factor 3 subunit G).
ncx-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable calcium:sodium antiporter activity; calmodulin binding activity; and metal ion binding activity. Predicted to be involved in metal ion transport. Predicted to be located in membrane. Expressed in dorsal nerve cord; head neurons; phasmid neurons; and ventral nerve cord.
vha-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Predicted to be part of proton-transporting V-type ATPase, V0 domain. Expressed in excretory cell; hypodermis; and intestinal cell. Human ortholog(s) of this gene implicated in thyroid gland carcinoma. Is an ortholog of human ATP6V0C (ATPase H+ transporting V0 subunit c).
pisy-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity. Predicted to be involved in phosphatidylinositol biosynthetic process. Predicted to be located in Golgi apparatus. Is an ortholog of human CDIPT (CDP-diacylglycerol--inositol 3-phosphatidyltransferase).
obr-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable cholesterol binding activity and sterol transporter activity. Involved in regulation of growth and transforming growth factor beta receptor signaling pathway. Predicted to be located in cytosol; intracellular membrane-bounded organelle; and membrane. Expressed in hypodermis; neurons; and pharyngeal muscle cell. Is an ortholog of human OSBPL5 (oxysterol binding protein like 5) and OSBPL8 (oxysterol binding protein like 8).
ceh-88 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Expressed in several structures, including excretory cell;
hyp12; neurons; tail hypodermis; and ventral nerve cord.
ceh-23 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in determination of adult lifespan; neuron differentiation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in intestine; nervous system; and tail.
ceh-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in brain development; neuron differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in several structures, including coelomocyte; head muscle; somatic nervous system; tail; and terminal bulb. Human ortholog(s) of this gene implicated in syndromic microphthalmia 11. Is an ortholog of human VAX1 (ventral anterior homeobox 1).
eif-3.E [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in nucleus. Predicted to be part of eukaryotic translation initiation factor 3 complex. Expressed in head and tail. Is an ortholog of human EIF3E (eukaryotic translation initiation factor 3 subunit E).
ugt-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1); UGT3A2 (UDP glycosyltransferase family 3 member A2); and UGT8 (UDP glycosyltransferase 8).
acl-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in cellular lipid metabolic process and glycerol-3-phosphate metabolic process. Located in mitochondrion. Expressed in muscle cell. Is an ortholog of human GPAM (glycerol-3-phosphate acyltransferase, mitochondrial).
F10G8.9 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 3-oxoacyl-[acyl-carrier-protein] synthase activity. Predicted to be involved in fatty acid biosynthetic process. Predicted to be located in mitochondrion. Is an ortholog of human OXSM (3-oxoacyl-ACP synthase, mitochondrial).
ugt-13 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1); UGT3A2 (UDP glycosyltransferase family 3 member A2); and UGT8 (UDP glycosyltransferase 8).
ugt-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1); UGT3A2 (UDP glycosyltransferase family 3 member A2); and UGT8 (UDP glycosyltransferase 8).
ugt-55 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1); UGT3A2 (UDP glycosyltransferase family 3 member A2); and UGT8 (UDP glycosyltransferase 8).
R02D3.8 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 3'-5'-RNA exonuclease activity. Involved in PERK-mediated unfolded protein response and innate immune response. Predicted to be located in cytoplasm. Is an ortholog of human ERI3 (ERI1 exoribonuclease family member 3).
ugt-14 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1); UGT3A2 (UDP glycosyltransferase family 3 member A2); and UGT8 (UDP glycosyltransferase 8).
ugt-36 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of human UGT3A1 (UDP glycosyltransferase family 3 member A1); UGT3A2 (UDP glycosyltransferase family 3 member A2); and UGT8 (UDP glycosyltransferase 8).
cct-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be located in cytoplasm and microtubule. Predicted to be part of chaperonin-containing T-complex. Is an ortholog of human CCT3 (chaperonin containing TCP1 subunit 3).
folt-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable folic acid binding activity and vitamin transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in biotin-responsive basal ganglia disease. Is an ortholog of human SLC19A3 (solute carrier family 19 member 3).
end-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in endodermal cell fate specification and mesodermal cell fate specification. Located in nucleus. Expressed in E; E lineage cell; Ea; Ep; and intestine.
dap-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be a structural constituent of ribosome. Predicted to be involved in apoptotic process. Predicted to be located in mitochondrial ribosome. Predicted to be part of mitochondrial small ribosomal subunit. Is an ortholog of human DAP3 (death associated protein 3).
alh-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in cellular aldehyde metabolic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in Sjogren-Larsson syndrome and arteriosclerosis. Is an ortholog of human ALDH3A1 (aldehyde dehydrogenase 3 family member A1); ALDH3A2 (aldehyde dehydrogenase 3 family member A2); and ALDH3B1 (aldehyde dehydrogenase 3 family member B1).
hst-3.1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Involved in heparan sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi lumen. Expressed in several structures, including coelomocyte; distal tip cell; neurons; non-striated muscle; and rectal epithelial cell. Is an ortholog of human HS3ST1 (heparan sulfate-glucosamine 3-sulfotransferase 1) and HS3ST5 (heparan sulfate-glucosamine 3-sulfotransferase 5).
aex-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable guanyl-nucleotide exchange factor activity. Involved in several processes, including egg-laying behavior; mating; and positive regulation of transport. Predicted to be located in cytosol. Expressed in neurons. Used to study alcohol use disorder. Is an ortholog of human MADD (MAP kinase activating death domain).
acl-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups. Located in endoplasmic reticulum. Expressed in head. Is an ortholog of human GPAT3 (glycerol-3-phosphate acyltransferase 3) and GPAT4 (glycerol-3-phosphate acyltransferase 4).
pag-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; transcription corepressor activity; and transcription corepressor binding activity. Involved in several processes, including negative regulation of secretion by cell; neuroblast fate specification; and regulation of locomotion. Located in nucleus. Expressed in several structures, including P1.aap; P11.aaap; P12.aaap; neurons; and retrovesicular ganglion. Used to study alcohol use disorder. Is an ortholog of human ZNF683 (zinc finger protein 683).
cgt-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ceramide glucosyltransferase activity. Involved in several processes, including glucosylceramide biosynthetic process; regulation of mesodermal cell fate specification; and regulation of protein localization to basolateral plasma membrane. Located in plasma membrane. Expressed in several structures, including germ line; pharyngeal muscle cell; pharyngeal-intestinal valve; rectal gland cell; and rectal valve cell. Is an ortholog of human UGCG (UDP-glucose ceramide glucosyltransferase).
ugt-46 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of several human genes including UGT3A1 (UDP glycosyltransferase family 3 member A1); UGT3A2 (UDP glycosyltransferase family 3 member A2); and UGT8 (UDP glycosyltransferase 8).
gpap-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 3'-nucleotidase activity. Predicted to be located in endomembrane system. Human ortholog(s) of this gene implicated in chondrodysplasia with joint dislocations gPAPP type. Is an ortholog of human BPNT2 (3'(2'), 5'-bisphosphate nucleotidase 2).
kmo-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable kynurenine 3-monooxygenase activity. Predicted to be involved in kynurenine metabolic process. Predicted to be located in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in schizophrenia. Is an ortholog of human KMO (kynurenine 3-monooxygenase).
ocam-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in M cell; Z1.p; Z4.a; male distal tip cell; and somatic gonad precursor based on RNA-seq and single-cell RNA-seq studies. Is affected by several genes including
eat-2;
elt-2; and
sir-2.1 based on tiling array; microarray; and RNA-seq studies. Is affected by Rifampin; allantoin; and Colistin based on RNA-seq and microarray studies.