Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in axon guidance; positive regulation of transcription by RNA polymerase II; and regulation of axon extension. Located in nucleus. Expressed in DA8; head muscle; head neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including congenital central hypoventilation syndrome; congenital fibrosis of the extraocular muscles 2; and neuroblastoma. Is an ortholog of human PHOX2A (paired like homeobox 2A).
Involved in single fertilization. Predicted to be located in membrane. Expressed in sperm. Is an ortholog of human DCST2 (DC-STAMP domain containing 2).
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in animal organ development; neuron development; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in dopaminergic neurons.
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in body wall musculature; neurons; and somatic nervous system.
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in dopaminergic neuron differentiation and regulation of transcription by RNA polymerase II. Acts upstream of or within lipid homeostasis. Part of chromatin. Expressed in amphid neurons and sensory neurons.
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed widely.
Enables GTP binding activity and GTPase activity. Involved in several processes, including establishment of mitotic spindle orientation; positive regulation of nematode male tail tip morphogenesis; and regulation of cellular component organization. Located in centrosome; cytoplasm; and plasma membrane. Expressed in several structures, including AIY; P8.pa; hermaphrodite gonad; hypodermal cell; and nerve ring. Used to study cerebral cavernous malformation. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; bipolar disorder; fibrosarcoma; and rhinitis. Is an ortholog of human CDC42 (cell division cycle 42).