- clp-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal dominant limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2A; hereditary spastic paraplegia 76; and stomach cancer. Is an ortholog of several human genes including CAPN1 (calpain 1); CAPN2 (calpain 2); and CAPN3 (calpain 3).
- clp-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Expressed in head; hypodermis; intestinal cell; muscle cell; and tail. Is an ortholog of human CAPN7 (calpain 7).
- clp-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in cytoplasm. Expressed in GABAergic neurons; body wall musculature; dorsal nerve cord; and ventral nerve cord. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal dominant limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2A; hereditary spastic paraplegia 76; and stomach cancer. Is an ortholog of several human genes including CAPN1 (calpain 1); CAPN2 (calpain 2); and CAPN3 (calpain 3).
- clp-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in cytoplasm. Expressed in hypodermis. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal dominant limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2A; hereditary spastic paraplegia 76; and stomach cancer. Is an ortholog of several human genes including CAPN1 (calpain 1); CAPN2 (calpain 2); and CAPN3 (calpain 3).
- asp-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable aspartic-type endopeptidase activity. Involved in programmed necrotic cell death. Located in lysosome. Expressed in intestine and uterus. Is an ortholog of human NAPSA (napsin A aspartic peptidase).
- clp-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Involved in several processes, including cellular response to calcium ion; muscle cell cellular homeostasis; and positive regulation of sarcomere organization. Located in M band. Expressed in GABAergic neurons; hypodermis; intestine; pharyngeal muscle cell; and vulva. Used to study Duchenne muscular dystrophy and hereditary spastic paraplegia. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal dominant limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2A; hereditary spastic paraplegia 76; and stomach cancer. Is an ortholog of human CAPN3 (calpain 3) and CAPN9 (calpain 9).
- asp-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable aspartic-type endopeptidase activity. Involved in programmed necrotic cell death. Located in lysosome. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; and neuronal ceroid lipofuscinosis 10. Is an ortholog of human CTSD (cathepsin D).
- clp-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in cytoplasm. Expressed in several structures, including excretory cell; hypodermis; neurons; ventral nerve cord; and vulva. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal dominant limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2A; and hereditary spastic paraplegia 76. Is an ortholog of human CAPN3 (calpain 3).
- clpp-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables serine-type endopeptidase activity. Involved in mitochondrial unfolded protein response and proteolysis. Located in mitochondrial matrix. Expressed in intestine. Human ortholog(s) of this gene implicated in Perrault syndrome. Is an ortholog of human CLPP (caseinolytic mitochondrial matrix peptidase proteolytic subunit).