col-33 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be a structural constituent of cuticle. Predicted to be located in membrane. Predicted to be part of collagen trimer. Is an ortholog of human COL21A1 (collagen type XXI alpha 1 chain).
col-77 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be a structural constituent of cuticle. Predicted to be located in membrane. Predicted to be part of collagen trimer. Human ortholog(s) of this gene implicated in Bethlem myopathy and Ullrich congenital muscular dystrophy. Is an ortholog of human COL6A2 (collagen type VI alpha 2 chain).
col-84 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be a structural constituent of cuticle. Predicted to be part of collagen trimer. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 5. Is an ortholog of human COLQ (collagen like tail subunit of asymmetric acetylcholinesterase).
col-14 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be a structural constituent of cuticle. Predicted to be located in membrane. Predicted to be part of collagen trimer. Human ortholog(s) of this gene implicated in Stickler syndrome and multiple epiphyseal dysplasia 6. Is an ortholog of human COL9A1 (collagen type IX alpha 1 chain).
glb-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables heme binding activity; iron ion binding activity; and oxygen binding activity. Predicted to be involved in oxygen transport and response to hypoxia. Expressed in neurons and somatic nervous system.
Y57G11C.3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 6-phosphogluconolactonase activity. Predicted to be involved in pentose-phosphate shunt, oxidative branch. Located in nucleus. Expressed in germ cell. Is an ortholog of human PGLS (6-phosphogluconolactonase).
cps-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables endonuclease activity; protein homodimerization activity; and sequence-specific DNA binding activity. Involved in RNA catabolic process and apoptotic DNA fragmentation. Located in mitochondrion. Is an ortholog of human ENDOG (endonuclease G).
pfkb-1.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in fructose 2,6-bisphosphate metabolic process. Predicted to be located in cytosol. Is an ortholog of several human genes including PFKFB1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1); PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2); and PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3).
pfkb-1.1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in fructose 2,6-bisphosphate metabolic process. Predicted to be located in cytosol. Is an ortholog of several human genes including PFKFB1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1); PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2); and PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3).
sas-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables identical protein binding activity and protein domain specific binding activity. Involved in centriole replication; protein localization; and regulation of cell cycle. Located in centriole and cytoplasm.
pfd-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable protein-folding chaperone binding activity. Predicted to be involved in chaperone-mediated protein complex assembly and protein folding. Located in cytoplasm. Expressed in body wall musculature; hypodermal cell; intestinal cell; and non-striated muscle. Is an ortholog of human PFDN6 (prefoldin subunit 6).
pbo-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables extracellular ligand-gated monoatomic ion channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Predicted to be located in neuron projection and synapse. Expressed in body wall musculature.
mua-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be a structural constituent of cytoskeleton. Involved in cell-cell adhesion. Located in hemidesmosome. Expressed in hypodermis; touch receptor neurons; uterus; and ventral cord neurons. Human ortholog(s) of this gene implicated in partial lipodystrophy; primary autosomal recessive microcephaly; and progressive myoclonus epilepsy 9. Is an ortholog of human LMNB2 (lamin B2).
gfat-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glutamine-fructose-6-phosphate transaminase (isomerizing) activity. Predicted to be involved in UDP-N-acetylglucosamine metabolic process; fructose 6-phosphate metabolic process; and protein N-linked glycosylation. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 12; obesity; and type 2 diabetes mellitus. Is an ortholog of human GFPT1 (glutamine--fructose-6-phosphate transaminase 1).
coq-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable oxidoreductase activity. Involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 6. Is an ortholog of human COQ6 (coenzyme Q6, monooxygenase).
pph-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable protein serine/threonine phosphatase activity. Involved in cortical actin cytoskeleton organization; establishment of mitotic spindle localization; and first cell cycle pseudocleavage. Located in astral microtubule and cell cortex. Is an ortholog of human PPP6C (protein phosphatase 6 catalytic subunit).
set-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables histone H3K9 dimethyltransferase activity and histone H3K9 trimethyltransferase activity. Involved in epigenetic regulation of gene expression. Part of chromatin. Expressed in embryonic cell; gonad; muscle cell; nervous system; and sperm. Is an ortholog of human SUV39H2 (SUV39H2 histone lysine methyltransferase).
sul-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables heparan sulfate 6-O-sulfotransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification. Predicted to be located in Golgi stack; cell surface; and endoplasmic reticulum. Is an ortholog of human SULF1 (sulfatase 1) and SULF2 (sulfatase 2).
tba-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to be located in cytoplasm and microtubule. Expressed in HSN; ciliated neurons; intestine; and vulva.
rgs-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of signal transduction. Human ortholog(s) of this gene implicated in nephrolithiasis. Is an ortholog of human RGS14 (regulator of G protein signaling 14).
haf-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Located in perinuclear endoplasmic reticulum. Expressed in germ line; intestine; and muscle cell. Is an ortholog of human ABCB8 (ATP binding cassette subfamily B member 8).
ncx-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable calcium:sodium antiporter activity. Predicted to be involved in intracellular calcium ion homeostasis and monoatomic cation transport. Predicted to be located in membrane. Expressed in ADLL and ADLR. Is an ortholog of human SLC8B1 (solute carrier family 8 member B1).
atf-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including ATF6-mediated unfolded protein response; determination of adult lifespan; and endoplasmic reticulum calcium ion homeostasis. Predicted to be located in nucleus. Expressed in several structures, including intestine; muscle cell; pharyngeal gland cell; rectum; and vulva. Human ortholog(s) of this gene implicated in achromatopsia 7. Is an ortholog of human ATF6 (activating transcription factor 6) and ATF6B (activating transcription factor 6 beta).
catp-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATPase-coupled monoatomic cation transmembrane transporter activity and polyamine transmembrane transporter activity. Involved in protein folding. Located in cytoplasmic vesicle and plasma membrane. Expressed in several structures, including egg-laying apparatus; gonad; oocyte; pharynx; and somatic gonad precursor. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in primary pulmonary hypertension. Is an ortholog of human ATP13A3 (ATPase 13A3).
arl-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables GTPase activity. Involved in intracellular transport. Located in axoneme; cytosol; and dendrite. Expressed in ciliated neurons. Used to study Bardet-Biedl syndrome and ciliopathy. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 1; Bardet-Biedl syndrome 3; and retinitis pigmentosa 55. Is an ortholog of human ARL6 (ADP ribosylation factor like GTPase 6).
cogc-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in gonad morphogenesis and regulation of cell migration. Predicted to be located in Golgi membrane. Predicted to be part of Golgi transport complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIl. Is an ortholog of human COG6 (component of oligomeric golgi complex 6).
ddx-10 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and RNA helicase activity. Predicted to be involved in rRNA processing. Predicted to be located in nucleus. Is an ortholog of human DDX10 (DEAD-box helicase 10).
par-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables protein kinase C binding activity and small GTPase binding activity. Involved in several processes, including establishment of mitotic spindle localization; gonad development; and polarity specification of anterior/posterior axis. Located in P granule and cell cortex. Is extrinsic component of cytoplasmic side of plasma membrane. Expressed in several structures, including ABa; EMS; Psub2; Psub3; and excretory cell. Is an ortholog of human PARD6B (
par-6 family cell polarity regulator beta).
hst-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable heparan sulfate 6-O-sulfotransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification and regulation of growth. Predicted to be located in membrane. Expressed in AIBL; AIBR; RIML; RIMR; and neurons. Human ortholog(s) of this gene implicated in Paganini-Miozzo syndrome and hypogonadotropic hypogonadism 15 with or without anosmia. Is an ortholog of human HS6ST1 (heparan sulfate 6-O-sulfotransferase 1).
cah-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be located in cytoplasm. Expressed in head neurons; nervous system; and tail neurons. Is an ortholog of human CA6 (carbonic anhydrase 6).
inx-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable gap junction hemi-channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Predicted to be located in gap junction and plasma membrane. Expressed in head neurons; pharyngeal cell; and rectal valve cell.
lsy-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables mRNA 3'-UTR binding activity. Involved in determination of left/right asymmetry in nervous system and miRNA-mediated post-transcriptional gene silencing. Expressed in ASEL; head neurons; and tail neurons.
aex-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable GTP binding activity and GTPase activity. Involved in exocytosis; positive regulation of defecation; and positive regulation of protein catabolic process. Located in synaptic vesicle. Expressed in ALML; ALMR; BDUL; BDUR; and neurons. Human ortholog(s) of this gene implicated in Griscelli syndrome type 2 and non-Langerhans-cell histiocytosis. Is an ortholog of human RAB27A (RAB27A, member RAS oncogene family).
egl-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable G protein-coupled peptide receptor activity. Involved in negative regulation of egg-laying behavior. Predicted to be located in plasma membrane. Expressed in GLR; nerve ring; and neurons.
gspd-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glucose-6-phosphate dehydrogenase activity. Predicted to be involved in glucose metabolic process and pentose-phosphate shunt, oxidative branch. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; diabetes mellitus (multiple); and favism. Is an ortholog of human G6PD (glucose-6-phosphate dehydrogenase).
col-43 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be a structural constituent of cuticle. Predicted to be located in membrane. Predicted to be part of collagen trimer. Expressed in hypodermis. Is an ortholog of human C1QTNF9 (C1q and TNF related 9); C1QTNF9B (C1q and TNF related 9B); and OTOL1 (otolin 1).
hsp-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Involved in mitochondrial unfolded protein response. Located in mitochondrion. Expressed in muscle cell. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; autosomal dominant sideroblastic anemia 4; and rheumatoid arthritis. Is an ortholog of human HSPA9 (heat shock protein family A (Hsp70) member 9).
ptps-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables 6-pyruvoyltetrahydropterin synthase activity and identical protein binding activity. Involved in tetrahydrobiopterin biosynthetic process. Predicted to be located in mitochondrion. Expressed in hypodermis and neurons. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia A and phenylketonuria. Is an ortholog of human PTS (6-pyruvoyltetrahydropterin synthase).
T03F6.3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glucosamine-6-phosphate deaminase activity and identical protein binding activity. Predicted to be involved in N-acetylglucosamine catabolic process; N-acetylneuraminate catabolic process; and glucosamine catabolic process. Predicted to be located in cytoplasm. Expressed in tail. Is an ortholog of human GNPDA1 (glucosamine-6-phosphate deaminase 1).
acl-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in cellular lipid metabolic process and glycerol-3-phosphate metabolic process. Located in mitochondrion. Expressed in muscle cell. Is an ortholog of human GPAM (glycerol-3-phosphate acyltransferase, mitochondrial).
eif-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ribosomal large subunit binding activity. Involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be located in cytosol and nucleolus. Predicted to be part of preribosome, large subunit precursor. Used to study obesity. Is an ortholog of human EIF6 (eukaryotic translation initiation factor 6).
mig-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable serine-type endopeptidase inhibitor activity. Involved in several processes, including anatomical structure morphogenesis; distal tip cell migration; and nematode larval development. Located in basement membrane. Expressed in several structures, including CAN; GLR; basal lamina; enteric muscle; and somatic gonad precursor. Is an ortholog of human PAPLN (papilin, proteoglycan like sulfated glycoprotein).
rme-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables small GTPase binding activity. Involved in endocytosis; molting cycle; and regulation of clathrin-dependent endocytosis. Located in clathrin-coated endocytic vesicle; early endosome; and plasma membrane. Expressed in several structures, including anterior gonad arm; coelomocyte; intestine; oocyte; and pharynx. Is an ortholog of human GAPVD1 (GTPase activating protein and VPS9 domains 1).
cct-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be located in cytoplasm. Predicted to be part of chaperonin-containing T-complex. Is an ortholog of human CCT6B (chaperonin containing TCP1 subunit 6B).
lpd-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable rRNA binding activity. Involved in lipid storage. Predicted to be located in membrane. Predicted to be part of preribosome, large subunit precursor. Is an ortholog of human PPAN (peter pan homolog) and PPAN-P2RY11 (PPAN-P2RY11 readthrough).
otpl-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable proton channel activity. Predicted to be involved in proton transmembrane transport. Predicted to be located in plasma membrane. Is an ortholog of human OTOP1 (otopetrin 1); OTOP2 (otopetrin 2); and OTOP3 (otopetrin 3).
csn-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable metallopeptidase activity. Predicted to be involved in oogenesis. Predicted to be located in cytoplasm and nucleus. Predicted to be part of COP9 signalosome. Is an ortholog of human COPS6 (COP9 signalosome subunit 6).
osm-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in several processes, including non-motile cilium assembly; response to osmotic stress; and sensory perception of mechanical stimulus. Located in cilium; cytoplasm; and neuronal cell body. Expressed in neurons. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy. Is an ortholog of human IFT52 (intraflagellar transport 52).
gpi-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glucose-6-phosphate isomerase activity and monosaccharide binding activity. Predicted to be involved in gluconeogenesis; glucose 6-phosphate metabolic process; and glycolytic process. Predicted to be located in cytosol. Expressed in head. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in several diseases, including congenital nonspherocytic hemolytic anemia; leukemia (multiple); and neuromuscular disease. Is an ortholog of human GPI (glucose-6-phosphate isomerase).
pfk-1.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable several functions, including 6-phosphofructokinase activity; carbohydrate derivative binding activity; and identical protein binding activity. Predicted to be involved in canonical glycolysis; fructose 1,6-bisphosphate metabolic process; and fructose 6-phosphate metabolic process. Predicted to be located in cytoplasm. Predicted to be part of 6-phosphofructokinase complex. Human ortholog(s) of this gene implicated in glycogen storage disease VII. Is an ortholog of human PFKL (phosphofructokinase, liver type); PFKM (phosphofructokinase, muscle); and PFKP (phosphofructokinase, platelet).
him-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables 3'-5' DNA helicase activity and enzyme binding activity. Involved in several processes, including determination of adult lifespan; meiotic nuclear division; and resolution of recombination intermediates. Located in chromosome and nucleus. Used to study Bloom syndrome. Human ortholog(s) of this gene implicated in Bloom syndrome. Is an ortholog of human BLM (BLM RecQ like helicase).
nol-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA binding activity. Involved in negative regulation of innate immune response. Predicted to be located in condensed nuclear chromosome and nucleolus. Predicted to be part of CURI complex; UTP-C complex; and small-subunit processome. Is an ortholog of human NOL6 (nucleolar protein 6).
dyf-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in intraciliary transport and non-motile cilium assembly. Located in dendrite and neuronal cell body. Expressed in ciliated neurons and hypodermis. Is an ortholog of human IFT46 (intraflagellar transport 46).
snf-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables PDZ domain binding activity and acetylcholine transmembrane transporter activity. Involved in acetylcholine transport; choline transport; and positive regulation of locomotion. Predicted to be located in postsynaptic membrane. Expressed in body wall musculature; enteric muscle; neurons; and vulval muscle. Used to study Duchenne muscular dystrophy. Human ortholog(s) of this gene implicated in hyperekplexia 3 and obesity. Is an ortholog of human SLC6A14 (solute carrier family 6 member 14) and SLC6A5 (solute carrier family 6 member 5).