Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation; hormone-mediated signaling pathway; and regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including Cpaaaa; Cpaaap; Cpaapa; Cpaapp; and germ line. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; carcinoma (multiple); congenital nongoitrous hypothyroidism 6; and cystic fibrosis. Is an ortholog of human PPARA (peroxisome proliferator activated receptor alpha) and THRA (thyroid hormone receptor alpha).
This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008]
This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. [provided by RefSeq, Jul 2008]
Enriched in sensory neurons based on RNA-seq studies. Is affected by several genes including daf-2; hpl-2; and set-2 based on RNA-seq and microarray studies.
Is affected by several genes including daf-2; eat-2; and sma-2 based on RNA-seq and microarray studies. Is affected by cadmium based on RNA-seq studies.
Predicted to be located in cytoplasm and nucleus. Is an ortholog of human CDK2AP1 (cyclin dependent kinase 2 associated protein 1) and CDK2AP2 (cyclin dependent kinase 2 associated protein 2).
Enriched in AFD and sensory neurons based on RNA-seq studies. Is affected by several genes including daf-2; eat-2; and smg-2 based on RNA-seq and microarray studies.
Involved in protein localization to ciliary inversin compartment. Located in ciliary inversin compartment. Expressed in neurons. Human ortholog(s) of this gene implicated in hypertension and nephronophthisis 2. Is an ortholog of human INVS (inversin).
Enables cadmium ion binding activity and zinc ion binding activity. Involved in response to cadmium ion and response to heat. Expressed in intestinal cell and intestine.
Is affected by several genes including daf-2; eat-2; and hda-2 based on RNA-seq and microarray studies. Is affected by five chemicals including Psoralens; allantoin; and metformin based on RNA-seq studies.
Is affected by several genes including daf-2; eat-2; and hpl-2 based on RNA-seq and microarray studies. Is affected by six chemicals including Zidovudine; Psoralens; and allantoin based on RNA-seq studies.
Is affected by several genes including daf-2; eat-2; and elt-2 based on RNA-seq and microarray studies. Is affected by nine chemicals including stavudine; Zidovudine; and Psoralens based on RNA-seq studies.
Is affected by several genes including daf-2; eat-2; and hpl-2 based on RNA-seq and microarray studies. Is affected by seven chemicals including metformin; Psoralens; and allantoin based on RNA-seq studies.
Is affected by several genes including daf-2; eat-2; and mut-2 based on microarray and RNA-seq studies. Is affected by seven chemicals including Psoralens; allantoin; and Sirolimus based on RNA-seq and microarray studies.
Is affected by rsr-2; daf-2; and eat-2 based on tiling array and microarray studies. Is predicted to encode a protein with the following domains: Protein of unknown function DUF5354 and Family of unknown function (DUF5354).
Is affected by several genes including daf-2; eat-2; and elt-2 based on tiling array and RNA-seq studies. Is affected by five chemicals including Psoralens; allantoin; and Sirolimus based on RNA-seq and microarray studies.
Predicted to enable endonuclease activity. Human ortholog(s) of this gene implicated in several diseases, including alcoholic liver cirrhosis; hypomyelinating leukodystrophy 20; and restless legs syndrome. Is an ortholog of several human genes including CNP (2',3'-cyclic nucleotide 3' phosphodiesterase); N4BP2 (NEDD4 binding protein 2); and N4BP2L2 (NEDD4 binding protein 2 like 2).
Predicted to enable protein folding chaperone. Predicted to be involved in protein folding. Located in endoplasmic reticulum; sarcomere; and striated muscle dense body. Is an ortholog of human PFDN2 (prefoldin subunit 2).
Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in fructose 2,6-bisphosphate metabolic process. Predicted to be located in cytosol. Is an ortholog of several human genes including PFKFB1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1); PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2); and PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3).
Enriched in male based on RNA-seq studies. Is affected by several genes including daf-2; eat-2; and hpl-2 based on RNA-seq and microarray studies. Is affected by cholesterol; Doxycycline; and paraquat based on RNA-seq studies.
Enriched in excretory gland cell based on single-cell RNA-seq studies. Is affected by several genes including daf-2; aak-2; and set-2 based on microarray and RNA-seq studies. Is affected by Acrylamide based on microarray studies.
Enriched in ASER based on RNA-seq studies. Is affected by several genes including eat-2; aak-2; and smg-2 based on RNA-seq studies. Is affected by tryptophan; Psoralens; and allantoin based on microarray and RNA-seq studies.
Enriched in germ line based on RNA-seq studies. Is affected by several genes including eat-2; met-2; and hpl-2 based on RNA-seq studies. Is affected by multi-walled carbon nanotube and atracurium based on RNA-seq studies.
Is affected by several genes including eat-2; clk-1; and hpl-2 based on microarray and RNA-seq studies. Is affected by four chemicals including multi-walled carbon nanotube; Colistin; and 2 based on RNA-seq and microarray studies.
Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in fructose 2,6-bisphosphate metabolic process. Predicted to be located in cytosol. Is an ortholog of several human genes including PFKFB1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1); PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2); and PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3).
Enriched in neurons based on RNA-seq studies. Is affected by several genes including daf-2; eat-2; and pmt-2 based on microarray and RNA-seq studies. Is affected by Ethanol and multi-walled carbon nanotube based on RNA-seq studies.
Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is an ortholog of several human genes including UGT2B10 (UDP glucuronosyltransferase family 2 member B10); UGT2B4 (UDP glucuronosyltransferase family 2 member B4); and UGT2B7 (UDP glucuronosyltransferase family 2 member B7).
Predicted to enable GTPase activity and U5 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in cytosol. Predicted to be part of U2-type catalytic step 2 spliceosome and U4/U6 x U5 tri-snRNP complex. Human ortholog(s) of this gene implicated in several diseases, including esophageal atresia; hepatitis B; and mandibulofacial dysostosis, Guion-Almeida type. Is an ortholog of human EFTUD2 (elongation factor Tu GTP binding domain containing 2).