Enriched in amphid neurons; amphid sheath cell; intestine; and somatic gonad precursor based on RNA-seq and single-cell RNA-seq studies. Is affected by several genes including
daf-16;
daf-2; and
skn-1 based on microarray; RNA-seq; tiling array; and proteomic studies. Is affected by twenty-one chemicals including tryptophan; 1-methylnicotinamide; and methylmercuric chloride based on microarray and RNA-seq studies. Human HSD17B14 enables estradiol 17-beta-dehydrogenase [NAD(P)] activity; identical protein binding activity; and testosterone 17-beta-dehydrogenase (NADP+) activity. Is predicted to encode a protein with the following domains: Short-chain dehydrogenase/reductase SDR; Enoyl-(Acyl carrier protein) reductase; and NAD(P)-binding domain superfamily. Is an ortholog of human HSD17B14 (hydroxysteroid 17-beta dehydrogenase 14).