age-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in several processes, including dauer entry; determination of adult lifespan; and regulation of synaptic assembly at neuromuscular junction. Located in cytoplasm and non-motile cilium. Part of phosphatidylinositol 3-kinase complex. Expressed in amphid neurons; anchor cell; hypodermis; and pharyngeal-intestinal valve. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Is an ortholog of human PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta); PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta); and PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma).
kin-23 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in head mesodermal cell based on RNA-seq studies. Is affected by several genes including
daf-16;
daf-12; and
sir-2.1 based on tiling array; RNA-seq; and microarray studies. Is affected by six chemicals including Psoralens; allantoin; and Sirolimus based on RNA-seq and microarray studies.
rad-23 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable polyubiquitin modification-dependent protein binding activity; proteasome binding activity; and ubiquitin binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleoplasm. Expressed in dorsal nerve cord; head; neurons; ventral nerve cord; and vulva. Is an ortholog of human RAD23A (RAD23 homolog A, nucleotide excision repair protein).
glb-23 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable several functions, including heme binding activity; oxygen binding activity; and oxygen carrier activity. Predicted to be involved in oxygen transport. Expressed in head neurons; lateral nerve cord; ventral cord neurons; and ventral nerve cord.
C34D4.4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in protein secretion and vesicle-mediated transport. Predicted to be located in membrane. Is an ortholog of human TVP23A (trans-golgi network vesicle protein 23 homolog A) and TVP23B (trans-golgi network vesicle protein 23 homolog B).
egl-23 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be located in membrane.
wdr-23 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including determination of adult lifespan; negative regulation of cellular response to manganese ion; and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in several cellular components, including intracellular membrane-bounded organelle; neuronal cell body; and striated muscle dense body. Expressed in ASIL; ASIR; head; muscle cell; and tail. Is an ortholog of human DCAF11 (DDB1 and CUL4 associated factor 11).
R11E3.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable L-ascorbic acid transmembrane transporter activity. Predicted to be involved in L-ascorbic acid transmembrane transport. Predicted to be located in membrane. Is an ortholog of human SLC23A1 (solute carrier family 23 member 1) and SLC23A2 (solute carrier family 23 member 2).
Y59E9AL.4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable L-ascorbic acid transmembrane transporter activity. Predicted to be involved in L-ascorbic acid transmembrane transport. Predicted to be located in membrane. Is an ortholog of human SLC23A1 (solute carrier family 23 member 1) and SLC23A2 (solute carrier family 23 member 2).
vab-23 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in several processes, including embryonic body morphogenesis; epidermis morphogenesis; and vulval development. Located in nuclear speck. Expressed in several structures, including hermaphrodite somatic gonadal cell; ventral uterine precursor; vulval cell; vulval muscle; and vulval precursor cell. Human ortholog(s) of this gene implicated in Miles-Carpenter syndrome. Is an ortholog of human ZC4H2 (zinc finger C4H2-type containing).
T07G12.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable L-ascorbic acid transmembrane transporter activity. Predicted to be involved in L-ascorbic acid transmembrane transport. Predicted to be located in membrane. Is an ortholog of human SLC23A1 (solute carrier family 23 member 1) and SLC23A2 (solute carrier family 23 member 2).
grl-23 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in AVK; FLP; and neurons based on microarray and RNA-seq studies. Is affected by several genes including
daf-16;
daf-2; and
daf-12 based on microarray; RNA-seq; and proteomic studies. Is affected by thirteen chemicals including methylmercuric chloride; Tunicamycin; and multi-walled carbon nanotube based on microarray and RNA-seq studies.
timm-23 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable mitochondrion targeting sequence binding activity and protein transmembrane transporter activity. Involved in protein import into mitochondrial matrix. Predicted to be located in membrane. Predicted to be part of TIM23 mitochondrial import inner membrane translocase complex. Is an ortholog of human TIMM23 (translocase of inner mitochondrial membrane 23).
daf-28 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable insulin receptor binding activity. Involved in several processes, including insulin receptor signaling pathway; negative regulation of dauer entry; and regulation of synaptic assembly at neuromuscular junction. Acts upstream of with a negative effect on protein import into nucleus. Located in extracellular space and synapse. Expressed in several structures, including distal tip cell; egg-laying apparatus; neurons; pharynx; and ventral nerve cord.
mig-23 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables ADP phosphatase activity; GDP phosphatase activity; and UDP phosphatase activity. Involved in several processes, including gonad morphogenesis; positive regulation of protein glycosylation; and ribonucleoside diphosphate catabolic process. Located in cytoplasm. Expressed in head and tail. Is an ortholog of human ENTPD4 (ectonucleoside triphosphate diphosphohydrolase 4) and ENTPD7 (ectonucleoside triphosphate diphosphohydrolase 7).
rps-23 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Predicted to be located in ribosome. Predicted to be part of cytosolic small ribosomal subunit and polysomal ribosome. Human ortholog(s) of this gene implicated in brachycephaly, trichomegaly, and developmental delay. Is an ortholog of human RPS23 (ribosomal protein S23).
daf-37 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables ascr#2 binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in G protein-coupled receptor signaling pathway. Located in non-motile cilium. Expressed in head neurons.
daf-11 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable adenylate cyclase activity; guanylate cyclase activity; and peptide receptor activity. Involved in several processes, including determination of adult lifespan; response to oxygen-containing compound; and signal transduction. Located in dendrite; neuronal cell body; and non-motile cilium. Expressed in ADLL; ADLR; ASHL; and ASHR.
gcy-18 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable adenylate cyclase activity; guanylate cyclase activity; and peptide receptor activity. Involved in detection of temperature stimulus; thermosensory behavior; and thermotaxis. Located in microvillus membrane and neuron projection terminus. Expressed in intestine and nervous system.
twk-23 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be located in membrane. Expressed in intestine; muscle cell; and neurons. Is an ortholog of human KCNK2 (potassium two pore domain channel subfamily K member 2).
daf-14 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; egg-laying behavior; and negative regulation of dauer larval development. Predicted to be part of heteromeric SMAD protein complex. Expressed in several structures, including anal sphincter muscle; excretory duct cell; intestine; nerve ring; and phasmid sheath cell.
sec-23 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable GTPase activator activity. Predicted to be involved in COPII-coated vesicle cargo loading. Located in endoplasmic reticulum exit site. Expressed in hypodermis. Human ortholog(s) of this gene implicated in Cowden syndrome 7; congenital dyserythropoietic anemia type II; and craniolenticulosutural dysplasia. Is an ortholog of human SEC23B (SEC23 homolog B, COPII coat complex component).
gcy-23 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable adenylate cyclase activity; guanylate cyclase activity; and peptide receptor activity. Involved in detection of temperature stimulus; thermosensory behavior; and thermotaxis. Located in neuron projection terminus. Expressed in AFDL and AFDR.
grsp-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in hypodermis based on tiling array studies. Is affected by several genes including
daf-16;
daf-2; and
daf-12 based on microarray; proteomic; and RNA-seq studies. Is affected by fifteen chemicals including bisphenol S; stavudine; and Zidovudine based on RNA-seq and microarray studies.