Involved in several processes, including DNA damage response; determination of adult lifespan; and telomere maintenance. Located in germ cell nucleus. Part of chromatin. Expressed in germ line. Is an ortholog of human HUS1B (HUS1 checkpoint clamp component B).
PHENOTYPE: Homozygotes for targeted null mutations die within 1 day postnatally with abnormal respiratory function and goal-oriented behavior toward dam. Mice homozygous for another allele exhibit abnormal TNFA-stimulated astrocyte extracellular vesicle release. [provided by MGI curators]