Predicted to enable ATP binding activity and protein kinase activity. Predicted to be located in membrane. Expressed in body wall musculature; neurons; seam cell; and vulval muscle.
doughnut on 2 (dnt) encodes a Ryk family Wnt receptor-tyrosine kinase-related protein. It can form homo- and heterodimers with the other two Ryks (encoded by Drl-2 and drl) via binding the ligand encoded by Wnt5. dnt and drl products act during embryonic muscle attachment site selection.
Derailed 2 (Drl-2) is a member of the RYK gene family encoding a receptor tyrosine kinase that transduces Wnt5 signaling. It regulates salivary gland positioning, muscle attachment site selection and olfactory system development. The products of Drl-2 and drl can play both cooperative and opposing roles, depending on the cells where they are differentially expressed.
derailed (drl) encodes an atypical receptor tyrosine kinase with the product of Wnt5 as a ligand. It controls axon guidance events during neural development.