dsh-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables receptor tyrosine kinase binding activity. Involved in Wnt signaling pathway, regulating spindle positioning. Predicted to be located in cytosol. Expressed in several structures, including germ line; gonad; neurons; tail; and vulva. Human ortholog(s) of this gene implicated in DiGeorge syndrome and autosomal dominant Robinow syndrome 2. Is an ortholog of human DVL1 (dishevelled segment polarity protein 1).
dsh-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable frizzled binding activity. Involved in several processes, including Wnt signaling pathway, regulating spindle positioning; embryonic morphogenesis; and left/right axis specification. Located in cell cortex. Expressed in several structures, including QL; QR; distal tip cell; midbody; and somatic gonad precursor. Human ortholog(s) of this gene implicated in DiGeorge syndrome; Robinow syndrome (multiple); and lung cancer. Is an ortholog of human DVL1 (dishevelled segment polarity protein 1).
mig-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable frizzled binding activity. Involved in several processes, including cell differentiation; inductive cell migration; and non-canonical Wnt signaling pathway. Located in cell cortex. Expressed in several structures, including distal tip cell; linker cell; nerve ring; posterior lateral left ganglion; and somatic gonad precursor. Human ortholog(s) of this gene implicated in DiGeorge syndrome; Robinow syndrome (multiple); and lung cancer. Is an ortholog of human DVL1 (dishevelled segment polarity protein 1); DVL2 (dishevelled segment polarity protein 2); and DVL3 (dishevelled segment polarity protein 3).