{"species":null,"page":"all","query":"eT1","results":[{"dead":false,"other_names":["C50C3.9","unc-72","CELE_C50C3.9","eT1","CE32168","C50C3.9c.1","C50C3.9b","CE24860","C50C3.9b.1","CE39702","C50C3.9c","C50C3.9a","C50C3.9a.1"],"description":"Enables calcium channel regulator activity and voltage-gated calcium channel activity. Involved in several processes, including egg-laying behavior; pharyngeal pumping; and serotonin receptor signaling pathway. Located in endoplasmic reticulum membrane and plasma membrane. Part of voltage-gated calcium channel complex. Expressed in head muscle; neurons; non-striated muscle; and ventral nerve cord. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 110 and retinal cone dystrophy 4. Is an ortholog of human CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3).","page_type":"gene","taxonomy":{"genus":"Caenorhabditis","id":"c_elegans","species":"elegans"},"name":{"id":"WBGene00006772","label":"unc-36","class":"gene","taxonomy":"c_elegans","highlight":{"other_names":["eT1"]},"other_names":["C50C3.9","unc-72","CELE_C50C3.9","eT1","CE32168","C50C3.9c.1","C50C3.9b","CE24860","C50C3.9b.1","CE39702","C50C3.9c","C50C3.9a","C50C3.9a.1"]},"label":"unc-36","legacy_description":"unc-36 encodes an alpha2/delta subunit of a voltage-gated calcium channel; unc-36 is required for normal locomotion and proper intracellular trafficking, presynaptic localization and functional maturation of the UNC-2 alpha1 subunit of a C. elegans CaV2 channel in sensory and motor neurons; unc-36 also functions in a calcium-dependent pathway that establishes left-right asymmetry in the nervous system during development; recordings of voltage-dependent calcium currents indicate that UNC-36 regulates voltage dependence, kinetics, and conductance of the EGL-19 alpha1 subunit of the body wall muscle voltage-dependent calcium channel; unc-36 is expressed in muscle cells and motor neurons; an UNC-36::GFP localizes to the endoplasmic reticulum and the plasma membrane.","allele":[{"class":"variation","id":"WBVar00843396","label":"gk913581"},{"class":"variation","id":"WBVar00843401","label":"gk447801"},{"class":"variation","label":"gk853575","id":"WBVar00843406"},{"class":"variation","id":"WBVar00843412","label":"gk735308"},{"class":"variation","id":"WBVar00144052","label":"e1501"},{"class":"variation","id":"WBVar00843387","label":"gk415332"},{"label":"gk595052","id":"WBVar00843410","class":"variation"},{"class":"variation","label":"gk179726","id":"WBVar00402969"},{"class":"variation","label":"gk629722","id":"WBVar00843398"},{"class":"variation","id":"WBVar01490774","label":"gk955037"},{"class":"variation","label":"e2341","id":"WBVar00144758"},{"id":"WBVar00843399","label":"gk658785","class":"variation"},{"id":"WBVar00402962","label":"gk179719","class":"variation"},{"class":"variation","label":"gk821661","id":"WBVar00843397"},{"class":"variation","id":"WBVar00843420","label":"gk709433"},{"label":"gk347790","id":"WBVar00843425","class":"variation"},{"id":"WBVar00843390","label":"gk429681","class":"variation"},{"label":"gk581888","id":"WBVar00843424","class":"variation"},{"label":"gk963887","id":"WBVar01499774","class":"variation"},{"label":"e2551","id":"WBVar00144872","class":"variation"},{"label":"gk179715","id":"WBVar00402958","class":"variation"},{"class":"variation","label":"gk735307","id":"WBVar00843402"},{"class":"variation","label":"gk445420","id":"WBVar00843413"},{"id":"WBVar00276116","label":"ok5306","class":"variation"},{"class":"variation","label":"gk613023","id":"WBVar00843389"},{"class":"variation","id":"WBVar01500260","label":"gk964518"},{"id":"WBVar00843418","label":"gk528155","class":"variation"},{"label":"e251","id":"WBVar00143063","class":"variation"},{"class":"variation","id":"WBVar00843400","label":"gk612403"},{"id":"WBVar00843409","label":"gk809087","class":"variation"},{"class":"variation","id":"WBVar00000053","label":"ad698"},{"class":"variation","label":"gk962865","id":"WBVar01499061"},{"class":"variation","id":"WBVar00143556","label":"e873"},{"class":"variation","label":"e548","id":"WBVar00143291"},{"class":"variation","id":"WBVar00843414","label":"gk846586"},{"label":"gk760040","id":"WBVar00843408","class":"variation"},{"label":"e418","id":"WBVar00143195","class":"variation"},{"id":"WBVar00402965","label":"gk179722","class":"variation"},{"class":"variation","id":"WBVar00843404","label":"gk314520"},{"class":"variation","label":"gk753046","id":"WBVar00843415"},{"class":"variation","label":"gk179714","id":"WBVar00402957"},{"label":"gk179716","id":"WBVar00402959","class":"variation"},{"id":"WBVar00843394","label":"gk861573","class":"variation"},{"class":"variation","label":"gk482496","id":"WBVar00843403"},{"class":"variation","id":"WBVar00402964","label":"gk179721"},{"label":"tm5498","id":"WBVar00600880","class":"variation"},{"label":"gk179725","id":"WBVar00402968","class":"variation"},{"class":"variation","id":"WBVar00843405","label":"gk408096"},{"label":"gk574990","id":"WBVar00843407","class":"variation"},{"label":"cxTi704","id":"WBVar00064526","class":"variation"},{"class":"variation","id":"WBVar00296261","label":"ky386"},{"class":"variation","label":"gk396440","id":"WBVar00843421"},{"class":"variation","id":"WBVar00843422","label":"gk879103"},{"id":"WBVar00843391","label":"gk527192","class":"variation"},{"class":"variation","label":"gk179711","id":"WBVar00402954"},{"id":"WBVar00843411","label":"gk850028","class":"variation"},{"class":"variation","label":"gk932077","id":"WBVar00843417"},{"id":"WBVar00402967","label":"gk179724","class":"variation"},{"id":"WBVar00402956","label":"gk179713","class":"variation"},{"class":"variation","id":"WBVar02132352","label":"h15167"},{"id":"WBVar00843423","label":"gk675817","class":"variation"},{"class":"variation","label":"gk440494","id":"WBVar00843395"},{"id":"WBVar00843419","label":"gk477966","class":"variation"},{"class":"variation","label":"gk382055","id":"WBVar00843392"},{"class":"variation","label":"gk944260","id":"WBVar01480001"},{"class":"variation","id":"WBVar00402966","label":"gk179723"},{"label":"gk844834","id":"WBVar00843393","class":"variation"},{"class":"variation","id":"WBVar00843388","label":"gk510749"},{"label":"gk179718","id":"WBVar00402961","class":"variation"},{"class":"variation","label":"gk179712","id":"WBVar00402955"},{"id":"WBVar00402963","label":"gk179720","class":"variation"},{"class":"variation","label":"gk179717","id":"WBVar00402960"},{"id":"WBVar00843416","label":"gk461371","class":"variation"},{"id":"WBVar01480000","label":"gk944259","class":"variation"}],"wbid":"WBGene00006772","merged_into":null,"species":{"key":"c_elegans","name":"Caenorhabditis elegans"}},{"page_type":"gene","taxonomy":{"id":"h_sapiens","species":"sapiens","genus":"Homo"},"other_names":[null,"endothelin-1","RGD:730848","PPET1","HDLCQ7","eT1","preproendothelin-1","QME","ARCND3"],"dead":false,"description":"This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]","label":"Edn1","name":{"class":"gene","label":"Edn1","id":"HGNC:3176","other_names":[null,"endothelin-1","RGD:730848","PPET1","HDLCQ7","eT1","preproendothelin-1","QME","ARCND3"],"highlight":{"other_names":["eT1"]},"taxonomy":"h_sapiens"},"legacy_description":null,"allele":null,"species":{"key":"h_sapiens","name":"Homo sapiens"},"wbid":"HGNC:3176","merged_into":null},{"label":"Ednra","name":{"id":"HGNC:3179","label":"Ednra","class":"gene","taxonomy":"h_sapiens","highlight":{"other_names":["endothelin receptor, ET1-specific type"]},"other_names":[null,"endothelin ET-A receptor","ETRA","hET-AR","endothelin receptor, ET1-specific type","endothelin-1-specific receptor","RGD:737537","MFDA","ETA-R","endothelin-1 receptor","ETA","endothelin receptor subtype A","endothelin A receptor","ETAR","ET-A","G protein-coupled receptor"]},"page_type":"gene","taxonomy":{"genus":"Homo","species":"sapiens","id":"h_sapiens"},"other_names":[null,"endothelin ET-A receptor","ETRA","hET-AR","endothelin receptor, ET1-specific type","endothelin-1-specific receptor","RGD:737537","MFDA","ETA-R","endothelin-1 receptor","ETA","endothelin receptor subtype A","endothelin A receptor","ETAR","ET-A","G protein-coupled receptor"],"dead":false,"description":"This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]","species":{"key":"h_sapiens","name":"Homo sapiens"},"merged_into":null,"wbid":"HGNC:3179","legacy_description":null,"allele":null},{"taxonomy":{"genus":"Caenorhabditis","id":"c_elegans","species":"elegans"},"page_type":"gene","description":null,"dead":false,"other_names":[null],"label":"mnm-1","name":{"label":"mnm-1","id":"WBGene00003379","class":"gene","highlight":null,"taxonomy":"c_elegans","other_names":[null]},"allele":[{"class":"variation","id":"WBVar00145219","label":"et1"}],"legacy_description":null,"species":{"key":"c_elegans","name":"Caenorhabditis elegans"},"merged_into":null,"wbid":"WBGene00003379"},{"label":"Ednrb","name":{"label":"Ednrb","id":"HGNC:3180","class":"gene","highlight":{"description_all":["Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3."]},"taxonomy":"h_sapiens","other_names":[null,"Hirschsprung disease 2","WS4A","ET-BR","endothelin receptor non-selective type","LINC00439","RGD:736090","ETRB","ETB","ET-B","ABCDS","long intergenic non-protein coding RNA 439","HSCR2","endothelin B receptor","ETB1","HSCR","ETBR","endothelin receptor subtype B1"]},"page_type":"gene","taxonomy":{"id":"h_sapiens","species":"sapiens","genus":"Homo"},"other_names":[null,"Hirschsprung disease 2","WS4A","ET-BR","endothelin receptor non-selective type","LINC00439","RGD:736090","ETRB","ETB","ET-B","ABCDS","long intergenic non-protein coding RNA 439","HSCR2","endothelin B receptor","ETB1","HSCR","ETBR","endothelin receptor subtype B1"],"dead":false,"description":"The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]","species":{"key":"h_sapiens","name":"Homo sapiens"},"wbid":"HGNC:3180","merged_into":null,"legacy_description":null,"allele":null}],"type":"gene","uri":"search/gene/eT1/all","count":5}