unc-36

Caenorhabditis elegans

Enables calcium channel regulator activity and voltage-gated calcium channel activity. Involved in several processes, including egg-laying behavior; pharyngeal pumping; and serotonin receptor signaling pathway. Located in endoplasmic reticulum membrane and plasma membrane. Part of voltage-gated calcium channel complex. Expressed in head muscle; neurons; non-striated muscle; and ventral nerve cord. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 110 and retinal cone dystrophy 4. Is an ortholog of human CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3).

Edn1

Homo sapiens

This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Ednra

Homo sapiens

This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

mnm-1

Caenorhabditis elegans

Ednrb

Homo sapiens

The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]