Predicted to enable acyltransferase activity. Involved in several processes, including egg-laying behavior; positive regulation of vulval development; and vulval development. Located in cytoplasmic side of apical plasma membrane. Expressed in several structures, including buccal cavity; excretory canal; hermaphrodite gonad; rectum; and vulval cell.
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including developmental process involved in reproduction; positive regulation of transcription by RNA polymerase II; and vulval development. Located in nucleus. Part of chromatin. Expressed in body wall musculature; egg-laying apparatus; head neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including congenital nongoitrous hypothyroidism 2; focal segmental glomerulosclerosis 7; and renal Wilms' tumor. Is an ortholog of human PAX2 (paired box 2); PAX5 (paired box 5); and PAX8 (paired box 8).
Predicted to enable K48-linked deubiquitinase activity and cysteine-type carboxypeptidase activity. Predicted to be involved in proteolysis. Is an ortholog of human MINDY1 (MINDY lysine 48 deubiquitinase 1) and MINDY2 (MINDY lysine 48 deubiquitinase 2).
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in anatomical structure morphogenesis and response to salt stress. Located in nucleus. Expressed in ciliated neurons; interfacial epithelial cell; intestine; labial sensillum; and tail. Human ortholog(s) of this gene implicated in posterior polymorphous corneal dystrophy 1. Is an ortholog of human OVOL1 (ovo like transcriptional repressor 1) and OVOL2 (ovo like zinc finger 2).
Involved in miRNA-mediated gene silencing by inhibition of translation and positive regulation of development, heterochronic. Expressed in P5.p hermaphrodite; P7.p hermaphrodite; RID; and seam cell. Used to study Parkinson's disease.