- lin-40 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable histone deacetylase binding activity; transcription coactivator activity; and transcription corepressor activity. Acts upstream of or within chromatin organization; mitochondrial unfolded protein response; and positive regulation of protein localization to nucleus. Located in nucleus. Part of NuRD complex. Expressed in distal tip cell and somatic cell. Is an ortholog of human MTA1 (metastasis associated 1) and MTA3 (metastasis associated 1 family member 3).
- Egr1 [Search on AGR]
Homo sapiens The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014]
- Nab1 [Search on AGR]
Homo sapiens Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to act upstream of or within endochondral ossification; nervous system development; and regulation of epidermis development. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
- Nab2 [Search on AGR]
Homo sapiens This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
- egrh-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); lung disease (multiple); and neuropathy (multiple). Is an ortholog of human EGR1 (early growth response 1) and EGR3 (early growth response 3).
- egl-27 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; chromatin binding activity; and enzyme binding activity. Involved in several processes, including egg-laying behavior; hemidesmosome assembly; and nematode male tail tip morphogenesis. Located in nucleus. Expressed in several structures, including Y cell; intestinal cell; neurons; pharynx; and somatic gonad precursor. Human ortholog(s) of this gene implicated in dentatorubral-pallidoluysian atrophy and schizophrenia. Is an ortholog of human RERE (arginine-glutamic acid dipeptide repeats).
- egrh-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of oocyte maturation and negative regulation of ovulation. Located in nucleus and perinuclear region of cytoplasm. Expressed in body wall musculature; hermaphrodite somatic gonadal cell; nervous system; pharynx; and sperm. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); lung disease (multiple); and neuropathy (multiple). Is an ortholog of human EGR1 (early growth response 1) and EGR3 (early growth response 3).
- grnd [Search on AGR]
Drosophila melanogaster grindelwald (grnd) encodes a receptor of the TNF superfamily ligand encoded by egr, which activates the intracellular JNK pathway. It is involved in apoptosis and neoplastic growth.
- wgn [Search on AGR]
Drosophila melanogaster wengen (wgn) encodes a receptor for tumor necrosis factor (TNF) ligands, such as the product of egr. Signalling by this receptor is involved in apoptosis, photoreceptor axon guidance and nutritional control of body size.
- sigmar [Search on AGR]
Drosophila melanogaster salivary glands marred (sigmar) encodes a TNFAIP8-like (TIPE) protein family member. Its expression levels are responsive to the TNF ligand encoded by egr. The product of sigmar contribute to JNK signaling modulation, cytoskeletal remodeling and autophagy.