{"type":"gene","page":"all","species":null,"results":[{"allele":[{"class":"variation","label":"ok2759","id":"WBVar00093858"},{"class":"variation","id":"WBVar00093857","label":"ok2757"},{"class":"variation","label":"ok2756","id":"WBVar00093856"},{"id":"WBVar00826097","label":"gk403463","class":"variation"},{"class":"variation","label":"hc57","id":"WBVar00087764"},{"class":"variation","label":"gk937293","id":"WBVar00826098"},{"id":"WBVar00087769","label":"hc62","class":"variation"}],"species":{"key":"c_elegans","name":"Caenorhabditis elegans"},"merged_into":null,"wbid":"WBGene00019630","other_names":["K10D2.4","apc-16","CELE_K10D2.4","CE02016","K10D2.4","K10D2.4.1"],"description":"Predicted to be involved in cell division; meiotic cell cycle; and protein ubiquitination.","label":"emb-1","legacy_description":"emb-1 encodes the anaphase-promoting complex (APC) subunit APC16; emb-1 functions as an essential component of the APC; loss of maternal emb-1 function results in a 1-cell arrest phenotype; temperature-sensitive alleles of emb-1 result in arrest in metaphase I; mutant defects are maternal-specific as emb-1 males are fertile; the zygotic phenotype of emb-1 is sterility; emb-1 behaves both genetically and phenotypically like other APC mutants, both alone and in combination with other APC mutants; the phenotype of emb-1 is enhanced by mutations in APC subunit genes; the emb-1 mutant is suppressed by mutations in SAC genes and fzy-1.","taxonomy":{"id":"c_elegans","species":"elegans","genus":"Caenorhabditis"},"dead":false,"page_type":"gene","name":{"class":"gene","id":"WBGene00019630","highlight":{"description_all":["emb-1 encodes the anaphase-promoting complex (APC) subunit APC16; emb-1 functions as an essential component","of the APC; loss of maternal emb-1 function results in a 1-cell arrest phenotype; temperature-sensitive","alleles of emb-1 result in arrest in metaphase I; mutant defects are maternal-specific as emb-1 males","are fertile; the zygotic phenotype of emb-1 is sterility; emb-1 behaves both genetically and phenotypically","like other APC mutants, both alone and in combination with other APC mutants; the phenotype of emb-1"]},"label":"emb-1","taxonomy":"c_elegans","other_names":["K10D2.4","apc-16","CELE_K10D2.4","CE02016","K10D2.4","K10D2.4.1"]}},{"taxonomy":{"id":"c_elegans","genus":"Caenorhabditis","species":"elegans"},"page_type":"gene","name":{"class":"gene","label":"emb-26","taxonomy":"c_elegans","other_names":[null,"him-12"],"id":"WBGene00001280","highlight":{"description_all":["emb-26 was identified in screens for recessive, temperature-sensitive (ts) mutations that result in arrested","embryonic development; emb-26 mutant embryos generally arrest at the end of cell proliferation (the","lima-bean stage); emb-26 escapers arrest at all larval stages and exhibit abnormal gonadogenesis; at","20 degrees C, emb-26 mutants also displays a meiotic defect; maternal emb-26 activity is necessary and"]}},"dead":false,"legacy_description":"emb-26 was identified in screens for recessive, temperature-sensitive (ts) mutations that result in arrested embryonic development; emb-26 mutant embryos generally arrest at the end of cell proliferation (the lima-bean stage); emb-26 escapers arrest at all larval stages and exhibit abnormal gonadogenesis; at 20 degrees C, emb-26 mutants also displays a meiotic defect; maternal emb-26 activity is necessary and sufficient for embryogenesis.","species":{"name":"Caenorhabditis elegans","key":"c_elegans"},"merged_into":null,"description":null,"other_names":[null,"him-12"],"wbid":"WBGene00001280","label":"emb-26","allele":[{"class":"variation","label":"g47","id":"WBVar00145380"}]},{"allele":[{"id":"WBVar00249088","label":"t1290","class":"variation"}],"merged_into":null,"species":{"key":"c_elegans","name":"Caenorhabditis elegans"},"label":"emb-60","description":null,"other_names":[null],"wbid":"WBGene00001298","legacy_description":"emb-60 was identified in screens for maternal-effect embryonic lethal mutations on linkage groups II and III; emb-60 mutant embryos display normal early cleavage patterns, but arrest with differentiated tissues arranged in an abnormal morphology; emb-60 mutations do not affect the pes-1::lacZ expression pattern in the early AB lineage, suggesting that emb-60 does not play a role in cell specification in these cells; emb-60 is uncloned.","dead":false,"page_type":"gene","name":{"class":"gene","label":"emb-60","taxonomy":"c_elegans","other_names":[null],"id":"WBGene00001298","highlight":{"description_all":["emb-60 was identified in screens for maternal-effect embryonic lethal mutations on linkage groups II","and III; emb-60 mutant embryos display normal early cleavage patterns, but arrest with differentiated","tissues arranged in an abnormal morphology; emb-60 mutations do not affect the pes-1::lacZ expression","pattern in the early AB lineage, suggesting that emb-60 does not play a role in cell specification in","these cells; emb-60 is uncloned."]}},"taxonomy":{"genus":"Caenorhabditis","species":"elegans","id":"c_elegans"}},{"label":"emb-23","wbid":"WBGene00001277","other_names":[null],"description":null,"merged_into":null,"species":{"key":"c_elegans","name":"Caenorhabditis elegans"},"allele":[{"label":"g39","id":"WBVar00145375","class":"variation"}],"name":{"label":"emb-23","other_names":[null],"taxonomy":"c_elegans","id":"WBGene00001277","highlight":{"description_all":["emb-23 was identified in screens for recessive, temperature-sensitive (ts) mutations that result in arrested","embryonic development; emb-23 mutant embryos generally arrest at the end of cell proliferation (the","lima-bean stage), having displayed prolonged mitoses during some cell division cycles; emb-23 escapers","survive to early larval stages and exhibit abnormal gonadogenesis; maternal emb-23 activity is necessary"]},"class":"gene"},"page_type":"gene","dead":false,"taxonomy":{"id":"c_elegans","genus":"Caenorhabditis","species":"elegans"},"legacy_description":"emb-23 was identified in screens for recessive, temperature-sensitive (ts) mutations that result in arrested embryonic development; emb-23 mutant embryos generally arrest at the end of cell proliferation (the lima-bean stage), having displayed prolonged mitoses during some cell division cycles; emb-23 escapers survive to early larval stages and exhibit abnormal gonadogenesis; maternal emb-23 activity is necessary and sufficient for embryogenesis."},{"name":{"class":"gene","label":"emb-21","other_names":[null],"taxonomy":"c_elegans","id":"WBGene00001275","highlight":{"description_all":["emb-21 was identified in screens for recessive, temperature-sensitive (ts) mutations that result in arrested","embryonic development; emb-21 mutant embryos generally arrest at the 26-to-30-cell stage of embryogenesis","having displayed prolonged mitoses during early cell divisions; some emb-21 escapers survive to later","larval stages and exhibit abnormal gonadogenesis; maternal emb-21 activity is necessary and sufficient"]}},"page_type":"gene","dead":false,"taxonomy":{"id":"c_elegans","genus":"Caenorhabditis","species":"elegans"},"legacy_description":"emb-21 was identified in screens for recessive, temperature-sensitive (ts) mutations that result in arrested embryonic development; emb-21 mutant embryos generally arrest at the 26-to-30-cell stage of embryogenesis having displayed prolonged mitoses during early cell divisions; some emb-21 escapers survive to later larval stages and exhibit abnormal gonadogenesis; maternal emb-21 activity is necessary and sufficient for embryogenesis.","merged_into":null,"species":{"key":"c_elegans","name":"Caenorhabditis elegans"},"label":"emb-21","other_names":[null],"description":null,"wbid":"WBGene00001275","allele":[{"class":"variation","id":"WBVar00145369","label":"g31"}]},{"wbid":"WBGene00001285","other_names":[null],"description":null,"label":"emb-31","species":{"key":"c_elegans","name":"Caenorhabditis elegans"},"merged_into":null,"allele":[{"class":"variation","label":"g55","id":"WBVar00145385"}],"taxonomy":{"species":"elegans","genus":"Caenorhabditis","id":"c_elegans"},"page_type":"gene","name":{"class":"gene","label":"emb-31","other_names":[null],"taxonomy":"c_elegans","id":"WBGene00001285","highlight":{"description_all":["emb-31 was identified in screens for recessive, temperature-sensitive (ts) mutations that result in arrested","embryonic development; emb-31 mutant embryos generally arrest at the end of cell proliferation (the","lima-bean stage), having exhibited abnormal gastrulation and defects in the E (gut) lineage; emb-31 escapers","arrest at early larval stages and exhibit abnormal gonadogenesis; maternal emb-31 activity is necessary"]}},"dead":false,"legacy_description":"emb-31 was identified in screens for recessive, temperature-sensitive (ts) mutations that result in arrested embryonic development; emb-31 mutant embryos generally arrest at the end of cell proliferation (the lima-bean stage), having exhibited abnormal gastrulation and defects in the E (gut) lineage; emb-31 escapers arrest at early larval stages and exhibit abnormal gonadogenesis; maternal emb-31 activity is necessary and sufficient for embryogenesis."},{"legacy_description":"emb-50 is required maternally for embryonic development; it is uncloned.","taxonomy":{"species":"elegans","genus":"Caenorhabditis","id":"c_elegans"},"page_type":"gene","dead":false,"name":{"label":"emb-50","taxonomy":"c_elegans","other_names":[null],"id":"WBGene00001294","highlight":{"description_all":["emb-50 is required maternally for embryonic development; it is uncloned."]},"class":"gene"},"allele":[{"id":"WBVar00249070","label":"t1181","class":"variation"}],"species":{"name":"Caenorhabditis elegans","key":"c_elegans"},"merged_into":null,"description":null,"other_names":[null],"wbid":"WBGene00001294","label":"emb-50"},{"taxonomy":{"species":"elegans","genus":"Caenorhabditis","id":"c_elegans"},"dead":false,"page_type":"gene","name":{"label":"emb-67","other_names":[null],"taxonomy":"c_elegans","id":"WBGene00001301","highlight":{"description_all":["emb-67 is required maternally for embryonic development; it is uncloned."]},"class":"gene"},"legacy_description":"emb-67 is required maternally for embryonic development; it is uncloned.","wbid":"WBGene00001301","other_names":[null],"description":null,"label":"emb-67","species":{"key":"c_elegans","name":"Caenorhabditis elegans"},"merged_into":null,"allele":[{"class":"variation","id":"WBVar00249075","label":"t1218"}]},{"merged_into":null,"species":{"key":"c_elegans","name":"Caenorhabditis elegans"},"label":"emb-47","wbid":"WBGene00001291","other_names":[null],"description":null,"allele":[{"class":"variation","label":"t1238","id":"WBVar00249079"}],"name":{"class":"gene","id":"WBGene00001291","highlight":{"description_all":["emb-47 is required maternally for embryonic development; it is uncloned."]},"label":"emb-47","taxonomy":"c_elegans","other_names":[null]},"page_type":"gene","dead":false,"taxonomy":{"id":"c_elegans","genus":"Caenorhabditis","species":"elegans"},"legacy_description":"emb-47 is required maternally for embryonic development; it is uncloned."},{"allele":[{"class":"variation","id":"WBVar01499519","label":"gk963581"},{"id":"WBVar01498960","label":"gk962707","class":"variation"},{"class":"variation","label":"gk964028","id":"WBVar01499887"},{"class":"variation","id":"WBVar01500067","label":"gk964260"},{"class":"variation","label":"gk963810","id":"WBVar01499710"},{"id":"WBVar01204569","label":"gk483264","class":"variation"},{"id":"WBVar01499888","label":"gk964029","class":"variation"}],"label":"T21H8.t1","description":"Is affected by emb-4; hrde-1; and lpd-3 based on RNA-seq studies.","other_names":["T21H8.t1","CELE_T21H8.T1","T21H8.t1"],"wbid":"WBGene00014843","merged_into":null,"species":{"key":"c_elegans","name":"Caenorhabditis elegans"},"legacy_description":null,"page_type":"gene","name":{"class":"gene","taxonomy":"c_elegans","other_names":["T21H8.t1","CELE_T21H8.T1","T21H8.t1"],"label":"T21H8.t1","highlight":{"description_all":["Is affected by emb-4; hrde-1; and lpd-3 based on RNA-seq studies."]},"id":"WBGene00014843"},"dead":false,"taxonomy":{"species":"elegans","genus":"Caenorhabditis","id":"c_elegans"}},{"legacy_description":"emb-28 is required maternally for normal gastrulation, embryonic mitosis, and cytoplasmic composition; it is uncloned.","taxonomy":{"genus":"Caenorhabditis","species":"elegans","id":"c_elegans"},"dead":false,"page_type":"gene","name":{"class":"gene","label":"emb-28","other_names":[null],"taxonomy":"c_elegans","id":"WBGene00001282","highlight":{"description_all":["emb-28 is required maternally for normal gastrulation, embryonic mitosis, and cytoplasmic composition"]}},"allele":[{"id":"WBVar00145382","label":"g49","class":"variation"}],"other_names":[null],"wbid":"WBGene00001282","description":null,"label":"emb-28","species":{"name":"Caenorhabditis elegans","key":"c_elegans"},"merged_into":null},{"taxonomy":{"id":"c_elegans","genus":"Caenorhabditis","species":"elegans"},"name":{"class":"gene","label":"emb-15","other_names":[null],"taxonomy":"c_elegans","id":"WBGene00001269","highlight":{"description_all":["emb-15 was identified in screens for recessive, temperature-sensitive (ts) mutations that result in arrested","embryonic development; emb-15 mutant embryos generally arrest during late morphogenesis, at the three-fold",", or pretzel, stage of embryonic development, with some escapers surviving to later larval stages; emb"]}},"page_type":"gene","dead":false,"legacy_description":"emb-15 was identified in screens for recessive, temperature-sensitive (ts) mutations that result in arrested embryonic development; emb-15 mutant embryos generally arrest during late morphogenesis, at the three-fold, or pretzel, stage of embryonic development, with some escapers surviving to later larval stages; emb-15 activity can be provided maternally or embryonically, and appears to be required for normal rates of mitosis and normal membrane reforming during embryogenesis.","species":{"key":"c_elegans","name":"Caenorhabditis elegans"},"merged_into":null,"description":null,"other_names":[null],"wbid":"WBGene00001269","label":"emb-15","allele":[{"class":"variation","label":"g15","id":"WBVar00145357"}]},{"label":"emb-19","wbid":"WBGene00001273","other_names":[null],"description":null,"merged_into":null,"species":{"name":"Caenorhabditis elegans","key":"c_elegans"},"allele":[{"class":"variation","id":"WBVar00145362","label":"g22"}],"name":{"id":"WBGene00001273","highlight":{"description_all":["emb-19 was identified in screens for recessive, temperature-sensitive (ts) mutations that result in arrested","embryonic development; emb-19 mutant embryos generally arrest during late morphogenesis, at the three-fold",", or pretzel, stage of embryonic development, with some escapers surviving to later larval stages; emb"]},"label":"emb-19","taxonomy":"c_elegans","other_names":[null],"class":"gene"},"page_type":"gene","dead":false,"taxonomy":{"species":"elegans","genus":"Caenorhabditis","id":"c_elegans"},"legacy_description":"emb-19 was identified in screens for recessive, temperature-sensitive (ts) mutations that result in arrested embryonic development; emb-19 mutant embryos generally arrest during late morphogenesis, at the three-fold, or pretzel, stage of embryonic development, with some escapers surviving to later larval stages; emb-19 activity can be provided maternally or embryonically, and appears to be required for normal rates of mitosis and normal membrane reforming during embryogenesis."},{"taxonomy":{"genus":"Caenorhabditis","species":"elegans","id":"c_elegans"},"page_type":"gene","name":{"id":"WBGene00001295","highlight":{"description_all":["emb-52 was identified in screens for maternal-effect embryonic lethal mutations on linkage groups II","and III; emb-52 mutant embryos display normal early cleavage patterns but arrest with differentiated","tissues arranged in an abnormal morphology; emb-52 is required for establishing the correct number of"]},"label":"emb-52","taxonomy":"c_elegans","other_names":[null],"class":"gene"},"dead":false,"legacy_description":"emb-52 was identified in screens for maternal-effect embryonic lethal mutations on linkage groups II and III; emb-52 mutant embryos display normal early cleavage patterns but arrest with differentiated tissues arranged in an abnormal morphology; emb-52 is required for establishing the correct number of pes-1::lacZ-expressing cells in the early AB lineage and thus is proposed to play a role in embryonic cell fate specification.","description":null,"other_names":[null],"wbid":"WBGene00001295","label":"emb-52","species":{"key":"c_elegans","name":"Caenorhabditis elegans"},"merged_into":null,"allele":[{"label":"t1265","id":"WBVar00249081","class":"variation"}]},{"legacy_description":"emb-85 was identified in screens for maternal-effect embryonic lethal mutations on linkage groups II and III; emb-85 mutant embryos display normal early cleavage patterns, but variably arrest with differentiated tissues arranged in an abnormal morphology; emb-85 is required for establishing the correct number of pes-1::lacZ-expressing cells in the early AB and D lineages and thus is proposed to play a role in embryonic cell fate specification.","name":{"class":"gene","other_names":[null],"taxonomy":"c_elegans","label":"emb-85","highlight":{"description_all":["emb-85 was identified in screens for maternal-effect embryonic lethal mutations on linkage groups II","and III; emb-85 mutant embryos display normal early cleavage patterns, but variably arrest with differentiated","tissues arranged in an abnormal morphology; emb-85 is required for establishing the correct number of"]},"id":"WBGene00001302"},"page_type":"gene","dead":false,"taxonomy":{"id":"c_elegans","species":"elegans","genus":"Caenorhabditis"},"allele":[{"id":"WBVar00249114","label":"t1483","class":"variation"}],"label":"emb-85","wbid":"WBGene00001302","other_names":[null],"description":null,"merged_into":null,"species":{"name":"Caenorhabditis elegans","key":"c_elegans"}},{"legacy_description":"emb-5 encodes the C. elegans ortholog of the Spt6 family of RNA polymerase II transcription elongation factors; first identified in screens for temperature-sensitive embryonic lethal mutations, emb-5 is required for the correct timing of the second E (endoderm)-cell division in the early embryo and thus, for normal embryonic gastrulation; in addition, emb-5 activity is required postembryonically for proper gonad development; in yeast two-hybrid studies, EMB-5 interacts with the intracellular domains of LIN-12 and GLP-1, suggesting that EMB-5 functions as a positive downstream effector in Notch-like signaling pathways during C. elegans development; emb-5 mRNA is most abundant during embryonic stages, with lower levels apparent during the L1-L3 larval stages, and even lower levels observed during L4.","dead":false,"page_type":"gene","name":{"label":"emb-5","other_names":["T04A8.14","CELE_T04A8.14","CE13120","T04A8.14.1","T04A8.14"],"taxonomy":"c_elegans","id":"WBGene00001259","highlight":{"description_all":["emb-5 encodes the C. elegans ortholog of the Spt6 family of RNA polymerase II transcription elongation","factors; first identified in screens for temperature-sensitive embryonic lethal mutations, emb-5 is","endoderm)-cell division in the early embryo and thus, for normal embryonic gastrulation; in addition, emb","5 activity is required postembryonically for proper gonad development; in yeast two-hybrid studies, EMB","-5 interacts with the intracellular domains of LIN-12 and GLP-1, suggesting that EMB-5 functions as a"]},"class":"gene"},"taxonomy":{"species":"elegans","genus":"Caenorhabditis","id":"c_elegans"},"allele":[{"class":"variation","label":"gk783654","id":"WBVar00823436"},{"id":"WBVar00823445","label":"gk428178","class":"variation"},{"class":"variation","id":"WBVar00823455","label":"gk717869"},{"label":"gk398669","id":"WBVar00823430","class":"variation"},{"id":"WBVar00396546","label":"gk173303","class":"variation"},{"class":"variation","id":"WBVar02157161","label":"or862"},{"class":"variation","id":"WBVar00823460","label":"gk663829"},{"id":"WBVar00823441","label":"gk323770","class":"variation"},{"class":"variation","id":"WBVar00396551","label":"gk173308"},{"class":"variation","id":"WBVar00823453","label":"gk936664"},{"label":"gk824801","id":"WBVar00823440","class":"variation"},{"class":"variation","id":"WBVar02157042","label":"or1154"},{"id":"WBVar00396550","label":"gk173307","class":"variation"},{"label":"gk851546","id":"WBVar00823431","class":"variation"},{"id":"WBVar00087773","label":"hc67","class":"variation"},{"class":"variation","id":"WBVar00823428","label":"gk469248"},{"id":"WBVar00823449","label":"gk350750","class":"variation"},{"label":"gk173304","id":"WBVar00396547","class":"variation"},{"id":"WBVar00396545","label":"gk173302","class":"variation"},{"class":"variation","label":"gk506509","id":"WBVar00823447"},{"class":"variation","label":"gk537435","id":"WBVar00823439"},{"class":"variation","label":"gk892716","id":"WBVar00823456"},{"id":"WBVar00823457","label":"gk360986","class":"variation"},{"class":"variation","id":"WBVar00823448","label":"gk916980"},{"id":"WBVar00823451","label":"gk618336","class":"variation"},{"class":"variation","id":"WBVar00823464","label":"gk893186"},{"label":"gk173300","id":"WBVar00396543","class":"variation"},{"class":"variation","id":"WBVar00823429","label":"gk408074"},{"class":"variation","label":"h4958","id":"WBVar02131917"},{"class":"variation","id":"WBVar00823454","label":"gk919706"},{"id":"WBVar00396548","label":"gk173305","class":"variation"},{"label":"gk505395","id":"WBVar00823444","class":"variation"},{"class":"variation","id":"WBVar00145391","label":"g65"},{"id":"WBVar00823461","label":"gk520020","class":"variation"},{"class":"variation","id":"WBVar00823450","label":"gk754903"},{"label":"gk518860","id":"WBVar00823438","class":"variation"},{"id":"WBVar02157021","label":"or1097","class":"variation"},{"class":"variation","id":"WBVar00396549","label":"gk173306"},{"id":"WBVar00823435","label":"gk549133","class":"variation"},{"label":"gk762440","id":"WBVar00823458","class":"variation"},{"id":"WBVar00823463","label":"gk671784","class":"variation"},{"label":"gk844815","id":"WBVar00823432","class":"variation"},{"label":"gk895517","id":"WBVar00823452","class":"variation"},{"id":"WBVar00823443","label":"gk421675","class":"variation"},{"class":"variation","label":"gk353204","id":"WBVar00823427"},{"id":"WBVar00823446","label":"gk934230","class":"variation"},{"class":"variation","id":"WBVar00145358","label":"g16"},{"label":"gk464713","id":"WBVar00823442","class":"variation"},{"class":"variation","label":"gk612985","id":"WBVar00823459"},{"class":"variation","id":"WBVar00823462","label":"gk484322"},{"label":"or789","id":"WBVar02157150","class":"variation"},{"label":"h6805","id":"WBVar02131916","class":"variation"},{"class":"variation","label":"gk173309","id":"WBVar00396552"},{"label":"hc61","id":"WBVar00087768","class":"variation"},{"id":"WBVar00823437","label":"gk350181","class":"variation"},{"class":"variation","label":"or975","id":"WBVar02157189"},{"class":"variation","id":"WBVar00823433","label":"gk883293"},{"label":"gk173301","id":"WBVar00396544","class":"variation"},{"label":"gk321804","id":"WBVar00823434","class":"variation"}],"merged_into":null,"species":{"key":"c_elegans","name":"Caenorhabditis elegans"},"label":"emb-5","description":"Predicted to enable histone binding activity and nucleosome binding activity. Predicted to be involved in nucleosome organization and transcription elongation by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription elongation factor complex. Expressed in tail. Is an ortholog of human SUPT6H (SPT6 homolog, histone chaperone and transcription elongation factor).","other_names":["T04A8.14","CELE_T04A8.14","CE13120","T04A8.14.1","T04A8.14"],"wbid":"WBGene00001259"},{"legacy_description":"emb-24 is required either maternally or zygotically throughout embryonic development for normal AB and E lineages, and for the completion of embryogenesis; it is uncloned.","page_type":"gene","dead":false,"name":{"id":"WBGene00001278","highlight":{"description_all":["emb-24 is required either maternally or zygotically throughout embryonic development for normal AB and"]},"label":"emb-24","other_names":[null],"taxonomy":"c_elegans","class":"gene"},"taxonomy":{"id":"c_elegans","species":"elegans","genus":"Caenorhabditis"},"allele":[{"class":"variation","label":"g40","id":"WBVar00145376"}],"label":"emb-24","other_names":[null],"wbid":"WBGene00001278","description":null,"merged_into":null,"species":{"key":"c_elegans","name":"Caenorhabditis elegans"}},{"page_type":"gene","name":{"highlight":{"description_all":["emb-8 encodes the C. elegans NADPH-cytochrome P450 reductase ortholog; by homology, EMB-8 is predicted","P450 monooxygenase enzymes that play a role in fatty acid modification; during embryonic development, emb","for proper anterior-posterior (A/P) polarity and localization of GLP-1, PAR-3, PAR-2, and P granules; emb","for formation of the secreted eggshell; genetic studies indicate that, in regulating A/P polarity, emb"]},"id":"WBGene00001262","other_names":["K10D2.6","drop-8","CELE_K10D2.6","CE02018","K10D2.6.1","K10D2.6"],"taxonomy":"c_elegans","label":"emb-8","class":"gene"},"dead":false,"taxonomy":{"id":"c_elegans","species":"elegans","genus":"Caenorhabditis"},"legacy_description":"emb-8 encodes the C. elegans NADPH-cytochrome P450 reductase ortholog; by homology, EMB-8 is predicted to function in the enzymatic reduction of the cytochrome P450 monooxygenase enzymes that play a role in fatty acid modification; during embryonic development, emb-8 activity is essential for normal interactions between the pronucleus/centrosome complex and the posterior cortex and thus, for proper anterior-posterior (A/P) polarity and localization of GLP-1, PAR-3, PAR-2, and P granules; emb-8 is also required for formation of the secreted eggshell; genetic studies indicate that, in regulating A/P polarity, emb-8 appears to function in the same pathway as pod-1 and pod-2.","merged_into":null,"species":{"key":"c_elegans","name":"Caenorhabditis elegans"},"label":"emb-8","other_names":["K10D2.6","drop-8","CELE_K10D2.6","CE02018","K10D2.6.1","K10D2.6"],"description":"Predicted to enable FMN binding activity; NADPH-hemoprotein reductase activity; and flavin adenine dinucleotide binding activity. Involved in eggshell formation and lipid biosynthetic process. Predicted to be located in cytosol. Expressed in intestine; neurons; and pharynx. Human ortholog(s) of this gene implicated in Antley-Bixler syndrome with disordered steroidogenesis; congenital adrenal hyperplasia; and cytochrome P450 oxidoreductase deficiency. 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in Z2/Z3;EMB-4 is also required for normal embryonic and postembryonicdevelopment, and promotes LIN-12 activity.","dead":false,"page_type":"gene","name":{"label":"emb-4","taxonomy":"c_elegans","other_names":["Y80D3A.2","mal-2","CELE_Y80D3A.2","sel-6","Y80D3A.2c.1","CE40670","Y80D3A.2b","Y80D3A.2a","CE45156","Y80D3A.2c","Y80D3A.2b.1","CE45135","Y80D3A.2a.1"],"id":"WBGene00001258","highlight":{"description_all":["emb-4 (also known as mal-2 or sel-6) encodes a nuclear proteinorthologous to human AQR/IBP160, an intron-binding","spliceosomal'Aquarius' protein with a helicase-like domain; EMB-4 is required forthe loss of PIE-1 and","histones from the germline at its Z2/Z3stage, and thus for the condensation of germline chromatin in 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Is an ortholog of C. elegans emb-8. In C. elegans, emb-8 is involved in eggshell formation and lipid biosynthetic process.","label":"CBN04891","legacy_description":null,"taxonomy":{"id":"c_brenneri","genus":"Caenorhabditis","species":"brenneri"},"page_type":"gene","dead":false,"name":{"id":"WBGene00143616","highlight":{"description_all":["Is an ortholog of C. elegans emb-8.","In C. elegans, emb-8 is involved in eggshell formation and lipid biosynthetic process."]},"label":"CBN04891","taxonomy":"c_brenneri","other_names":["CBN04891","CBN04891","CBN04891.1","CN29073"],"class":"gene"}},{"allele":[{"class":"variation","label":"gk197995","id":"WBVar00421238"},{"id":"WBVar01499633","label":"gk963722","class":"variation"},{"id":"WBVar00898565","label":"gk693679","class":"variation"}],"merged_into":null,"species":{"key":"c_elegans","name":"Caenorhabditis elegans"},"label":"C04C3.9","description":"Enriched in arcade cell; pharyngeal-intestinal valve cell; and rectal gland cell based on RNA-seq and single-cell RNA-seq studies. 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Predicted to be part of anaphase-promoting complex. Is an ortholog of C. elegans emb-30. 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Is an ortholog of C. elegans emb-4.","merged_into":null,"species":{"key":"c_remanei","name":"Caenorhabditis remanei"},"allele":null,"page_type":"gene","name":{"class":"gene","label":"Cre-emb-4","other_names":["CRE11354","cr01.sctg95.wum.15","CRE11354.1","RP45201","CRE11354"],"taxonomy":"c_remanei","id":"WBGene00067464","highlight":{"description_all":["Is an ortholog of C. elegans emb-4."]}},"dead":false,"taxonomy":{"species":"remanei","genus":"Caenorhabditis","id":"c_remanei"},"legacy_description":null},{"legacy_description":null,"taxonomy":{"species":"volvulus","genus":"Onchocerca","id":"o_volvulus"},"page_type":"gene","name":{"id":"WBGene00243163","highlight":{"description_all":["Is an ortholog of C. elegans emb-4."]},"label":"Ovo-emb-4","other_names":["OVOC6354","OVOC6354","OVP13630","OVOC6354.1"],"taxonomy":"o_volvulus","class":"gene"},"dead":false,"allele":null,"species":{"name":"Onchocerca volvulus","key":"o_volvulus"},"merged_into":null,"description":"Predicted to enable helicase activity. 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Used to study skin disease.","merged_into":null,"species":{"name":"Caenorhabditis elegans","key":"c_elegans"},"allele":[{"class":"variation","id":"WBVar02148976","label":"tm9710"},{"class":"variation","id":"WBVar00143307","label":"e571"},{"class":"variation","id":"WBVar00739836","label":"gk338735"},{"id":"WBVar00143242","label":"e487","class":"variation"},{"class":"variation","label":"e1359","id":"WBVar00143940"},{"class":"variation","id":"WBVar00739845","label":"gk434370"},{"id":"WBVar00739846","label":"gk562241","class":"variation"},{"id":"WBVar00143638","label":"e961","class":"variation"},{"id":"WBVar00739847","label":"gk356771","class":"variation"},{"class":"variation","label":"e1280","id":"WBVar00143886"},{"id":"WBVar00739844","label":"gk624172","class":"variation"},{"id":"WBVar00739838","label":"gk826807","class":"variation"},{"id":"WBVar00143244","label":"e489","class":"variation"},{"class":"variation","id":"WBVar01498435","label":"gk963053"},{"id":"WBVar00739842","label":"gk548013","class":"variation"},{"id":"WBVar00739840","label":"gk936581","class":"variation"},{"id":"WBVar01499702","label":"gk963801","class":"variation"},{"label":"sc78","id":"WBVar00242697","class":"variation"},{"label":"q292","id":"WBVar00241063","class":"variation"},{"id":"WBVar00142906","label":"e8","class":"variation"},{"class":"variation","label":"gk689144","id":"WBVar00739839"},{"class":"variation","id":"WBVar00739841","label":"gk463314"},{"id":"WBVar00739837","label":"gk735213","class":"variation"},{"class":"variation","id":"WBVar00242683","label":"sc38"},{"class":"variation","label":"e115","id":"WBVar00142972"},{"class":"variation","label":"e445","id":"WBVar00143215"},{"id":"WBVar00739843","label":"gk412946","class":"variation"}],"dead":false,"page_type":"gene","name":{"class":"gene","id":"WBGene00001064","highlight":{"description_all":["with other cuticular collagens such as dpy-10 and sqt-1, and suppresses mutations in glp-1, mup-1, and emb"]},"label":"dpy-2","other_names":["T14B4.6","CELE_T14B4.6","rol-2","CE04953","T14B4.6.1","T14B4.6"],"taxonomy":"c_elegans"},"taxonomy":{"id":"c_elegans","genus":"Caenorhabditis","species":"elegans"},"legacy_description":"The dpy-2 gene encodes an unusual cuticular collagen that is required for maintaining the normal body length of the animal in later larval stages; dpy-2 interacts with other cuticular collagens such as dpy-10 and sqt-1, and suppresses mutations in glp-1, mup-1, and emb-5."},{"legacy_description":null,"page_type":"gene","name":{"label":"CJA10822","other_names":["CJA10822","CJA10822","JA56335","CJA10822.1"],"taxonomy":"c_japonica","id":"WBGene00130026","highlight":{"description_all":["Is an ortholog of C. elegans col-135 and emb-9."]},"class":"gene"},"dead":false,"taxonomy":{"id":"c_japonica","species":"japonica","genus":"Caenorhabditis"},"allele":null,"merged_into":null,"species":{"name":"Caenorhabditis japonica","key":"c_japonica"},"label":"CJA10822","other_names":["CJA10822","CJA10822","JA56335","CJA10822.1"],"wbid":"WBGene00130026","description":"Is predicted to encode a protein with the following domains: Collagen triple helix repeat and Collagen triple helix repeat (20 copies). 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Orthologous to human EMB (embigin); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.","wbid":"RGD:621067","merged_into":null,"species":{"key":"r_norvegicus","name":"Rattus norvegicus"},"legacy_description":null,"page_type":"gene","dead":false,"name":{"class":"gene","id":"RGD:621067","highlight":{"description_all":["Orthologous to human EMB (embigin); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol"]},"label":"emb","other_names":[null],"taxonomy":"r_norvegicus"},"taxonomy":{"species":"norvegicus","genus":"Rattus","id":"r_norvegicus"}},{"dead":false,"page_type":"gene","name":{"class":"gene","label":"Cbr-emb-5","taxonomy":"c_briggsae","other_names":["CBG18001","CBG_18001","CBP10840","CBG18001.1","CBG18001"],"id":"WBGene00037500","highlight":{"description_all":["Is an ortholog of C. elegans emb-5."]}},"taxonomy":{"species":"briggsae","genus":"Caenorhabditis","id":"c_briggsae"},"legacy_description":null,"merged_into":null,"species":{"key":"c_briggsae","name":"Caenorhabditis briggsae"},"label":"Cbr-emb-5","description":"Predicted to enable DNA binding activity. Predicted to be involved in nucleobase-containing compound metabolic process and positive regulation of transcription elongation by RNA polymerase II. Is an ortholog of C. elegans emb-5.","other_names":["CBG18001","CBG_18001","CBP10840","CBG18001.1","CBG18001"],"wbid":"WBGene00037500","allele":null},{"legacy_description":null,"name":{"class":"gene","label":"Cjp-emb-5","other_names":["CJA12507","CJA12507.1","JA56994","CJA12507"],"taxonomy":"c_japonica","id":"WBGene00131711","highlight":{"description_all":["Is an ortholog of C. elegans emb-5."]}},"page_type":"gene","dead":false,"taxonomy":{"species":"japonica","genus":"Caenorhabditis","id":"c_japonica"},"allele":null,"label":"Cjp-emb-5","description":"Predicted to enable DNA binding activity. Predicted to be involved in nucleobase-containing compound metabolic process and positive regulation of transcription elongation by RNA polymerase II. 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Predicted to be involved in DNA integration; DNA transposition; and mRNA splicing, via spliceosome. Predicted to be part of spliceosomal complex. Is an ortholog of C. elegans emb-4.","other_names":["CJA03727","JA51630","CJA03727b.1","CJA03727b","CJA03727a.1","CJA03727a","JA49573"],"wbid":"WBGene00122931","merged_into":null,"species":{"name":"Caenorhabditis japonica","key":"c_japonica"},"allele":null,"page_type":"gene","name":{"class":"gene","id":"WBGene00122931","highlight":{"description_all":["Is an ortholog of C. elegans emb-4."]},"label":"Cjp-emb-4.2","taxonomy":"c_japonica","other_names":["CJA03727","JA51630","CJA03727b.1","CJA03727b","CJA03727a.1","CJA03727a","JA49573"]},"dead":false,"taxonomy":{"id":"c_japonica","genus":"Caenorhabditis","species":"japonica"},"legacy_description":null},{"legacy_description":null,"taxonomy":{"id":"p_pacificus","genus":"Pristionchus","species":"pacificus"},"name":{"label":"PPA00710","taxonomy":"p_pacificus","other_names":["PPA00710","UMM-S50-33.7","GENEPREDICTION_SNAP300000067435","GENEPREDICTION_SNAP300000067438","PPA00710.1","PP66467","PPA00710"],"id":"WBGene00090264","highlight":{"description_all":["Is an ortholog of C. elegans C05D11.1 and emb-5."]},"class":"gene"},"page_type":"gene","dead":false,"allele":null,"species":{"key":"p_pacificus","name":"Pristionchus pacificus"},"merged_into":null,"other_names":["PPA00710","UMM-S50-33.7","GENEPREDICTION_SNAP300000067435","GENEPREDICTION_SNAP300000067438","PPA00710.1","PP66467","PPA00710"],"description":"Predicted to enable DNA binding activity; ion binding activity; and protein kinase activity. Predicted to be involved in nucleobase-containing compound metabolic process and positive regulation of transcription elongation by RNA polymerase II. Is an ortholog of C. elegans C05D11.1 and emb-5.","wbid":"WBGene00090264","label":"PPA00710"},{"name":{"class":"gene","label":"let-268","taxonomy":"c_elegans","other_names":["F52H3.1","CELE_F52H3.1","F52H3.1.3","F52H3.1.1","CE03397","F52H3.1","F52H3.1.2","F52H3.1.4"],"id":"WBGene00002497","highlight":{"description_all":["collagen secreted and incorporated into the basement membrane during embryogenesis (and encoded partly by emb"]}},"page_type":"gene","dead":false,"taxonomy":{"species":"elegans","genus":"Caenorhabditis","id":"c_elegans"},"legacy_description":"let-268 encodes a procollagen lysyl hydroxylase that processes type IV collagen, a collagen secreted and incorporated into the basement membrane during embryogenesis (and encoded partly by emb-9); LET-268 activity is essential for type IV collagen processing and secretion and for the stability, but not the formation of, the basement membrane that provides mechanical support to body wall muscle once contraction begins; LET-268 also appears to be required for pharyngeal muscle contraction.","label":"let-268","other_names":["F52H3.1","CELE_F52H3.1","F52H3.1.3","F52H3.1.1","CE03397","F52H3.1","F52H3.1.2","F52H3.1.4"],"description":"Enables UDP-glucose:glycoprotein glucosyltransferase activity. Involved in collagen biosynthetic process and protein glycosylation. Predicted to be located in endoplasmic reticulum. Expressed in GLR and body wall musculature. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome kyphoscoliotic type 1; hepatocellular carcinoma; and lung adenocarcinoma. Is an ortholog of human PLOD1 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 1).","wbid":"WBGene00002497","merged_into":null,"species":{"name":"Caenorhabditis elegans","key":"c_elegans"},"allele":[{"class":"variation","label":"gk561761","id":"WBVar00759960"},{"class":"variation","id":"WBVar00759973","label":"gk599681"},{"label":"gk415589","id":"WBVar00759971","class":"variation"},{"label":"ttTi1170","id":"WBVar00253412","class":"variation"},{"label":"gk152051","id":"WBVar00375294","class":"variation"},{"id":"WBVar00375303","label":"gk152060","class":"variation"},{"id":"WBVar00759958","label":"gk412950","class":"variation"},{"class":"variation","id":"WBVar00089097","label":"mn198"},{"class":"variation","label":"gk152050","id":"WBVar00375293"},{"class":"variation","id":"WBVar00759972","label":"gk796947"},{"class":"variation","label":"gk152058","id":"WBVar00375301"},{"class":"variation","label":"gk813423","id":"WBVar00759962"},{"label":"gk725411","id":"WBVar00759944","class":"variation"},{"id":"WBVar01498435","label":"gk963053","class":"variation"},{"label":"gk152053","id":"WBVar00375296","class":"variation"},{"class":"variation","label":"gk152059","id":"WBVar00375302"},{"class":"variation","label":"gk152061","id":"WBVar00375304"},{"label":"gk341498","id":"WBVar00759966","class":"variation"},{"label":"gk618998","id":"WBVar00759952","class":"variation"},{"id":"WBVar00759957","label":"gk651682","class":"variation"},{"label":"gk815993","id":"WBVar00759959","class":"variation"},{"id":"WBVar00241484","label":"ra414","class":"variation"},{"class":"variation","id":"WBVar00759967","label":"gk717785"},{"label":"gk152054","id":"WBVar00375297","class":"variation"},{"class":"variation","label":"gk549059","id":"WBVar00759953"},{"id":"WBVar00759975","label":"gk798524","class":"variation"},{"label":"gk680877","id":"WBVar00759976","class":"variation"},{"class":"variation","label":"gk959379","id":"WBVar01495116"},{"label":"gk517268","id":"WBVar00759974","class":"variation"},{"class":"variation","id":"WBVar00375299","label":"gk152056"},{"id":"WBVar00759946","label":"gk628732","class":"variation"},{"class":"variation","label":"gk867247","id":"WBVar00759955"},{"class":"variation","label":"gk813424","id":"WBVar00759965"},{"class":"variation","id":"WBVar00759977","label":"gk388647"},{"id":"WBVar00759969","label":"gk391637","class":"variation"},{"label":"gk647142","id":"WBVar00759963","class":"variation"},{"id":"WBVar00759978","label":"gk597289","class":"variation"},{"id":"WBVar00759956","label":"gk827307","class":"variation"},{"class":"variation","id":"WBVar00375298","label":"gk152055"},{"class":"variation","id":"WBVar00759947","label":"gk781696"},{"id":"WBVar00375305","label":"gk152062","class":"variation"},{"class":"variation","label":"gk152052","id":"WBVar00375295"},{"class":"variation","id":"WBVar00759968","label":"gk832713"},{"class":"variation","id":"WBVar00759970","label":"gk314001"},{"class":"variation","label":"gk152049","id":"WBVar00375292"},{"id":"WBVar00759954","label":"gk426241","class":"variation"},{"class":"variation","label":"gk351893","id":"WBVar00759943"},{"label":"gk439016","id":"WBVar00759949","class":"variation"},{"label":"gk412951","id":"WBVar00759961","class":"variation"},{"label":"gk317569","id":"WBVar00759950","class":"variation"},{"id":"WBVar00759951","label":"gk450553","class":"variation"},{"class":"variation","label":"gk553803","id":"WBVar00759948"},{"label":"gk962682","id":"WBVar01498940","class":"variation"},{"id":"WBVar00759945","label":"gk458126","class":"variation"},{"label":"gk152057","id":"WBVar00375300","class":"variation"},{"class":"variation","label":"mn189","id":"WBVar00089095"},{"id":"WBVar01499702","label":"gk963801","class":"variation"},{"class":"variation","id":"WBVar00759964","label":"gk908485"},{"label":"gk152063","id":"WBVar00375306","class":"variation"}]},{"allele":[{"label":"gk385387","id":"WBVar00729732","class":"variation"},{"id":"WBVar00729736","label":"gk676224","class":"variation"},{"label":"gk555504","id":"WBVar00729734","class":"variation"},{"class":"variation","label":"tm947","id":"WBVar00249969"},{"label":"gk870790","id":"WBVar00729737","class":"variation"},{"class":"variation","id":"WBVar00729735","label":"gk495860"},{"label":"gk628707","id":"WBVar00729729","class":"variation"},{"class":"variation","id":"WBVar00365375","label":"gk142132"},{"class":"variation","id":"WBVar00729738","label":"gk752955"},{"id":"WBVar00729733","label":"gk691754","class":"variation"},{"class":"variation","label":"gk858451","id":"WBVar00729739"},{"class":"variation","id":"WBVar01498435","label":"gk963053"},{"class":"variation","label":"gk391060","id":"WBVar00729730"},{"class":"variation","label":"gk579834","id":"WBVar00729731"},{"class":"variation","label":"gk963801","id":"WBVar01499702"}],"label":"ify-1","other_names":["C27A2.3","CELE_C27A2.3","C27A2.3","CE04103","C27A2.3.1"],"wbid":"WBGene00002068","description":"Enables protease binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including cortical granule exocytosis; nuclear division; and protein stabilization. Located in condensed chromosome; cytoplasm; and spindle microtubule. Expressed in germ cell.","merged_into":null,"species":{"name":"Caenorhabditis elegans","key":"c_elegans"},"legacy_description":"ify-1 encodes a rapidly evolving protein ligand of FZY-1, with only 53% identity between C. elegans and C. briggsae and with no visible homologs in more distant species; IFY-1 binds FZY-1 and SEP-1 in yeast two-hybrid assays; ify-1(RNAi) and sep-1(RNAi) animals arrest as one-cell embryos with disorganized chromosomes, supporting the hypothesis that IFY-1 is a securin; the fzy-1(h1983) mutation blocks FZY-1 binding to IFY-1, but not to MDF-2, another possible FZY-1 ligand; IFY-1 protein accumulates abnormally in developmentally arrested one-cell emb-30 embryos.","page_type":"gene","name":{"class":"gene","label":"ify-1","taxonomy":"c_elegans","other_names":["C27A2.3","CELE_C27A2.3","C27A2.3","CE04103","C27A2.3.1"],"id":"WBGene00002068","highlight":{"description_all":["another possible FZY-1 ligand; IFY-1 protein accumulates abnormally in developmentally arrested one-cell emb"]}},"dead":false,"taxonomy":{"species":"elegans","genus":"Caenorhabditis","id":"c_elegans"}},{"allele":[{"class":"variation","label":"gk121073","id":"WBVar00344316"},{"label":"gk333533","id":"WBVar00667839","class":"variation"},{"id":"WBVar00344317","label":"gk121074","class":"variation"},{"label":"gk962706","id":"WBVar01498959","class":"variation"},{"class":"variation","label":"gk540567","id":"WBVar00667842"},{"class":"variation","id":"WBVar01499054","label":"gk962858"},{"class":"variation","label":"gk963902","id":"WBVar01499786"},{"class":"variation","label":"gk963849","id":"WBVar01499739"},{"class":"variation","label":"gk920639","id":"WBVar00667843"},{"label":"gk900348","id":"WBVar00667841","class":"variation"},{"class":"variation","label":"gk477412","id":"WBVar00667845"},{"label":"gk121075","id":"WBVar00344318","class":"variation"},{"class":"variation","id":"WBVar00667844","label":"gk669077"},{"label":"gk666927","id":"WBVar00667840","class":"variation"},{"id":"WBVar00344319","label":"gk121076","class":"variation"},{"class":"variation","id":"WBVar00344320","label":"gk121077"},{"class":"variation","label":"ok1310","id":"WBVar00092543"},{"label":"gk825664","id":"WBVar00667846","class":"variation"}],"label":"cdc-26","other_names":["B0511.9","tag-265","CELE_B0511.9","mat-4","B0511.9d","B0511.9c.1","CE41861","CE26854","B0511.9b.1","B0511.9a.1","B0511.9c","B0511.9d.1","CE46530","CE44875","B0511.9a","B0511.9b"],"description":"Predicted to be involved in cell division; meiotic cell cycle; and protein ubiquitination. Predicted to be located in nucleus. Expressed in germ line.","wbid":"WBGene00015235","merged_into":null,"species":{"name":"Caenorhabditis elegans","key":"c_elegans"},"legacy_description":"cdc-26 encodes, by alternative splicing, two isoforms of a probableanaphase-promoting complex/cyclosome (APC/C) component that has crypticorthology to budding yeast Cdc26p, and that is required for normalmeiosis and asymmetric one-cell embryonic division; although CDC-26 andCdc26p have little obvious sequence similarity, they do share a commonmotif in their N-terminal domains, and yeast cdc26 mutants can berescued by transgenic C. elegans CDC-26; CDC-26 binds EMB-27 in yeasttwo-hybrid experiments; weak cdc-26(RNAi) induces loss of asymmetryduring the first embryonic cell division of AB/P1, while strongcdc-26(RNAi) arrests embryos at meiotic metaphase I; in weakly defectiveone-cell cdc-26(RNAi) embryos, PAR-3 is mislocalized from the anteriorto the entire cortex, while PAR-2 is mislocalized from the posteriorcortex to cytoplasm.","name":{"class":"gene","other_names":["B0511.9","tag-265","CELE_B0511.9","mat-4","B0511.9d","B0511.9c.1","CE41861","CE26854","B0511.9b.1","B0511.9a.1","B0511.9c","B0511.9d.1","CE46530","CE44875","B0511.9a","B0511.9b"],"taxonomy":"c_elegans","label":"cdc-26","highlight":{"description_all":["N-terminal domains, and yeast cdc26 mutants can berescued by transgenic C. elegans CDC-26; CDC-26 binds EMB"]},"id":"WBGene00015235"},"page_type":"gene","dead":false,"taxonomy":{"genus":"Caenorhabditis","species":"elegans","id":"c_elegans"}},{"legacy_description":"cdc-25.3 encodes a tyrosine phosphatase that is a member of the cell division cycle 25 (CDC25) family of cell cycle regulators that includes Schizosaccharomyces pombe CDC25 and Drosophila string; cdc-25.3 is one of four cdc-25 genes in C. elegans and while it is known to be expressed in hermaphrodites, the precise function of cdc-25.3 is not yet clear; cdc-25.3 may function redundantly with cdc-25.2 during embryonic development and redundantly with cdc-25.1, cdc-25.2, and emb-29 during meiosis.","taxonomy":{"species":"elegans","genus":"Caenorhabditis","id":"c_elegans"},"page_type":"gene","name":{"label":"cdc-25.3","taxonomy":"c_elegans","other_names":["ZK637.11","CELE_ZK637.11","CE00429","ZK637.11.1","ZK637.11"],"id":"WBGene00000388","highlight":{"description_all":["redundantly with cdc-25.2 during embryonic development and redundantly with cdc-25.1, cdc-25.2, and emb"]},"class":"gene"},"dead":false,"allele":[{"class":"variation","label":"gk840568","id":"WBVar00847500"},{"id":"WBVar00404314","label":"gk181071","class":"variation"},{"label":"gk831442","id":"WBVar00847499","class":"variation"},{"label":"ok358","id":"WBVar00091655","class":"variation"},{"class":"variation","label":"gk181065","id":"WBVar00404308"},{"label":"gk181068","id":"WBVar00404311","class":"variation"},{"label":"gk427973","id":"WBVar00847501","class":"variation"},{"id":"WBVar00847503","label":"gk866020","class":"variation"},{"id":"WBVar00847502","label":"gk335505","class":"variation"},{"id":"WBVar00847504","label":"gk760048","class":"variation"},{"label":"gk964518","id":"WBVar01500260","class":"variation"},{"id":"WBVar00847497","label":"gk405092","class":"variation"},{"class":"variation","label":"gk181067","id":"WBVar00404310"},{"class":"variation","id":"WBVar02148449","label":"tn1712"},{"class":"variation","id":"WBVar00404313","label":"gk181070"},{"label":"gk181064","id":"WBVar00404307","class":"variation"},{"class":"variation","label":"gk605636","id":"WBVar00847498"},{"label":"gk181069","id":"WBVar00404312","class":"variation"},{"class":"variation","id":"WBVar00404309","label":"gk181066"},{"label":"gk963887","id":"WBVar01499774","class":"variation"},{"id":"WBVar00847496","label":"gk508514","class":"variation"},{"class":"variation","id":"WBVar00847495","label":"gk582965"},{"class":"variation","id":"WBVar00091526","label":"ok221"}],"other_names":["ZK637.11","CELE_ZK637.11","CE00429","ZK637.11.1","ZK637.11"],"wbid":"WBGene00000388","description":"Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in G2/M transition of mitotic cell cycle; positive regulation of G2/M transition of mitotic cell cycle; and positive regulation of G2/MI transition of meiotic cell cycle. Located in nucleus. Expressed in germ line. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive polycystic kidney disease; endometrial hyperplasia; and reproductive organ cancer (multiple). Is an ortholog of human CDC25A (cell division cycle 25A); CDC25B (cell division cycle 25B); and CDC25C (cell division cycle 25C).","label":"cdc-25.3","species":{"key":"c_elegans","name":"Caenorhabditis elegans"},"merged_into":null},{"page_type":"gene","name":{"class":"gene","label":"mig-6","other_names":["C37C3.6","cpg-17","ppn-1","CELE_C37C3.6","CE17535","C37C3.6a","CE17536","C37C3.6b","C37C3.6c.1","C37C3.6c","C37C3.6a.1","C37C3.6a.2","C37C3.6b.1","CE30735"],"taxonomy":"c_elegans","id":"WBGene00003242","highlight":{"description_all":["by regulating the localization of the MIG-17 metalloproteinase and possibly the amount of functional EMB"]}},"dead":false,"taxonomy":{"id":"c_elegans","genus":"Caenorhabditis","species":"elegans"},"legacy_description":"mig-6 encodes at least two protein isoforms (long and short) that are highly similar to the extracellular matrix proteins papilin and lacunin; mig-6 is an essential gene required for embryonic hypodermal cell enclosure and normal excretory canal cell function in L1 larvae; MIG-6(S) activity is required cell nonautonomously for the ventral to dorsal phase of distal tip cell (DTC) migration and appears to function by regulating the localization of the MIG-17 metalloproteinase and possibly the amount of functional EMB-9 or LET-2 collagen in the basement membrane; MIG-6(L) activity is required cell autonomously in the DTCs for regulating the rate at which the DTCs migrate at all phases; MIG-6 is expressed in embryos and larvae; in embryos, MIG-6 is expressed in body wall muscles, where it appears to localize to the cell surface; in larvae, MIG-6 is detected in the basement membranes of the gonad primordium, pharynx, and intestine.","label":"mig-6","wbid":"WBGene00003242","other_names":["C37C3.6","cpg-17","ppn-1","CELE_C37C3.6","CE17535","C37C3.6a","CE17536","C37C3.6b","C37C3.6c.1","C37C3.6c","C37C3.6a.1","C37C3.6a.2","C37C3.6b.1","CE30735"],"description":"Predicted to enable serine-type endopeptidase inhibitor activity. Involved in several processes, including anatomical structure morphogenesis; distal tip cell migration; and nematode larval development. Located in basement membrane. Expressed in several structures, including CAN; GLR; basal lamina; enteric muscle; and somatic gonad precursor. 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