Enables MAP kinase kinase activity; mitogen-activated protein kinase kinase kinase binding activity; and protein serine kinase activity. Involved in several processes, including defense response to other organism;
p38MAPK cascade; and positive regulation of macromolecule biosynthetic process. Expressed in excretory canal; linker cell; neurons; rectal epithelium; and uterine-vulval cell. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in several diseases, including Pick's disease; female reproductive organ cancer (multiple); and progressive supranuclear palsy. Is an ortholog of human MAP2K3 (mitogen-activated protein kinase kinase 3) and MAP2K6 (mitogen-activated protein kinase kinase 6).