Enables MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding activity; and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including defense response to other organism; determination of adult lifespan; and positive regulation of macromolecule biosynthetic process. Located in axon cytoplasm; neuronal cell body; and postsynaptic density. Expressed in head; rectal gland cell; and tail. Used to study amphetamine abuse. Human ortholog(s) of this gene implicated in Huntington's disease and perinatal necrotizing enterocolitis. Is an ortholog of human MAP3K5 (mitogen-activated protein kinase kinase kinase 5).
Expressed in body wall musculature; germ line; hypodermis; intestine; and pharynx. Is predicted to encode a protein with the following domains: Phosducin, N-terminal domain superfamily; Phosducin; Thioredoxin-like superfamily; and Phosducin, thioredoxin-like domain. Is an ortholog of human PDC (phosducin) and PDCL (phosducin like).
Involved in negative regulation of turning behavior involved in mating. Predicted to be located in extracellular region. Expressed in PVM; head; nerve ring; and tail.