mes-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables histone H3K27 methyltransferase activity. Involved in epigenetic regulation of gene expression; germ-line stem cell division; and tissue development. Part of PcG protein complex and nucleosome. Expressed in Z2; Z3; germ line; hypodermis; and intestine. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); and respiratory system cancer (multiple). Is an ortholog of human EZH1 (enhancer of zeste 1 polycomb repressive complex 2 subunit) and EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit).