Enriched in cephalic sheath cell; coelomocyte; germ line; intestine; and neurons based on tiling array; RNA-seq; and microarray studies. Is affected by several genes including
skn-1;
hsf-1; and
aak-2 based on microarray and RNA-seq studies. Is affected by six chemicals including hydrogen sulfide; rotenone; and levamisole based on microarray and RNA-seq studies. Human SIKE1 enables protein kinase binding activity and small GTPase binding activity. Is predicted to encode a protein with the following domain: SIKE family. Is an ortholog of human FGFR1OP2 (FGFR1 oncogene partner 2) and SIKE1 (suppressor of IKBKE 1).