pha-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; pharynx development; and positive regulation of metabolic process. Located in nucleus. Expressed in several structures, including arcade cell; enteric muscle; gonad; pharynx; and rectum. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); lung carcinoma (multiple); and type 2 diabetes mellitus. Is an ortholog of human FOXA1 (forkhead box A1) and FOXA2 (forkhead box A2).
fkh-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Expressed in head neurons.
fkh-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.
fkh-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Located in nucleus.
fkh-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables DNA-binding transcription factor activity. Involved in several processes, including nematode larval development; neuron differentiation; and non-motile cilium assembly. Located in nucleus. Expressed in several structures, including AWB; Daaa; body wall muscle cell from D lineage; head muscle; and somatic nervous system. Is an ortholog of human FOXG1 (forkhead box G1).
fkh-10 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in gonad and pharyngeal neurons. Is an ortholog of human FOXL3 (forkhead box L3) and FOXL3-OT1.
fkh-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in several structures, including intestine; neurons; pharynx; reproductive system; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); communication disorder (multiple); and tuberculosis (multiple). Is an ortholog of human FOXP2 (forkhead box P2).
fkh-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables sequence-specific DNA binding activity. Involved in male germ-line sex determination and male gonad development. Predicted to be located in nucleus. Expressed in gonadal sheath cell; male gonad; somatic gonad precursor; spermatheca; and in male. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 4. Is an ortholog of human FOXI2 (forkhead box I2) and FOXI3 (forkhead box I3).
fkh-8 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in ASEL; ASER; head neurons; neurons; and tail neurons. Human ortholog(s) of this gene implicated in several diseases, including lymphedema-distichiasis syndrome; obesity; and type 2 diabetes mellitus. Is an ortholog of human FOXC2 (forkhead box C2); FOXL3 (forkhead box L3); and FOXL3-OT1.
SRAE_X000160500 [Browse genome (BioProject PRJEB125)] [Search on AGR]
Strongyloides ratti Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans
unc-130 and
pes-1 and members of the C. elegans fkh gene class including
fkh-6. In C. elegans,
fkh-6 is involved in male germ-line sex determination and male gonad development.
PPA38872 [Browse genome (BioProject PRJNA12644)] [Search on AGR]
Pristionchus pacificus Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans
unc-130 and
pes-1 and members of the C. elegans fkh gene class including
fkh-6. In C. elegans,
fkh-6 is involved in male germ-line sex determination and male gonad development.
CRE23445 [Browse genome (BioProject PRJNA577507)] [Search on AGR]
Caenorhabditis remanei Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans
fkh-10;
fkh-9; and
let-381. In C. elegans,
fkh-9 is involved in several processes, including axon regeneration; determination of adult lifespan; and learning or memory.
Cbn-fkh-6 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans
fkh-6. In C. elegans,
fkh-6 is involved in male germ-line sex determination and male gonad development.
Cbr-fkh-6 [Browse genome (BioProject PRJNA10731)] [Search on AGR]
Caenorhabditis briggsae Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans
fkh-6. In C. elegans,
fkh-6 is involved in male germ-line sex determination and male gonad development.
Cre-fkh-6 [Browse genome (BioProject PRJNA577507)] [Search on AGR]
Caenorhabditis remanei Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans
fkh-6. In C. elegans,
fkh-6 is involved in male germ-line sex determination and male gonad development.
Bma-fkh-6 [Browse genome (BioProject PRJNA10729)] [Search on AGR]
Brugia malayi Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans
fkh-6. In C. elegans,
fkh-6 is involved in male germ-line sex determination and male gonad development.
Cjp-fkh-6 [Browse genome (BioProject PRJNA12591)] [Search on AGR]
Caenorhabditis japonica Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans
fkh-6. In C. elegans,
fkh-6 is involved in male germ-line sex determination and male gonad development.
Ppa-fkh-9 [Browse genome (BioProject PRJNA12644)] [Search on AGR]
Pristionchus pacificus Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans
fkh-9. In C. elegans,
fkh-9 is involved in several processes, including axon regeneration; determination of adult lifespan; and learning or memory.
Bma-fkh-2 [Browse genome (BioProject PRJNA10729)] [Search on AGR]
Brugia malayi Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans
fkh-2. In C. elegans,
fkh-2 is involved in several processes, including nematode larval development; neuron differentiation; and non-motile cilium assembly.
Cbn-fkh-9 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans
fkh-9. In C. elegans,
fkh-9 is involved in several processes, including axon regeneration; determination of adult lifespan; and learning or memory.
Cbr-fkh-2 [Browse genome (BioProject PRJNA10731)] [Search on AGR]
Caenorhabditis briggsae Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans
fkh-2. In C. elegans,
fkh-2 is involved in several processes, including nematode larval development; neuron differentiation; and non-motile cilium assembly.
Cbr-fkh-9 [Browse genome (BioProject PRJNA10731)] [Search on AGR]
Caenorhabditis briggsae Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans
fkh-9. In C. elegans,
fkh-9 is involved in several processes, including axon regeneration; determination of adult lifespan; and learning or memory.
Cjp-fkh-9 [Browse genome (BioProject PRJNA12591)] [Search on AGR]
Caenorhabditis japonica Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans
fkh-9. In C. elegans,
fkh-9 is involved in several processes, including axon regeneration; determination of adult lifespan; and learning or memory.
Cre-fkh-2 [Browse genome (BioProject PRJNA577507)] [Search on AGR]
Caenorhabditis remanei Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans
fkh-2. In C. elegans,
fkh-2 is involved in several processes, including nematode larval development; neuron differentiation; and non-motile cilium assembly.
TMUE_3000011083 [Browse genome (BioProject PRJEB126)] [Search on AGR]
Trichuris muris Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans
fkh-2. In C. elegans,
fkh-2 is involved in several processes, including nematode larval development; neuron differentiation; and non-motile cilium assembly.
Bma-fkh-9.2 [Browse genome (BioProject PRJNA10729)] [Search on AGR]
Brugia malayi Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans
fkh-9. In C. elegans,
fkh-9 is involved in several processes, including axon regeneration; determination of adult lifespan; and learning or memory.
Ovo-fkh-9 [Browse genome (BioProject PRJEB513)] [Search on AGR]
Onchocerca volvulus Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans
fkh-9. In C. elegans,
fkh-9 is involved in several processes, including axon regeneration; determination of adult lifespan; and learning or memory.
Bma-fkh-9.1 [Browse genome (BioProject PRJNA10729)] [Search on AGR]
Brugia malayi Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans
fkh-9. In C. elegans,
fkh-9 is involved in several processes, including axon regeneration; determination of adult lifespan; and learning or memory.
Cbn-fkh-2 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans
fkh-2. In C. elegans,
fkh-2 is involved in several processes, including nematode larval development; neuron differentiation; and non-motile cilium assembly.
Cjp-fkh-2 [Browse genome (BioProject PRJNA12591)] [Search on AGR]
Caenorhabditis japonica Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans
fkh-2. In C. elegans,
fkh-2 is involved in several processes, including nematode larval development; neuron differentiation; and non-motile cilium assembly.
Cre-fkh-9 [Browse genome (BioProject PRJNA577507)] [Search on AGR]
Caenorhabditis remanei Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans
fkh-9. In C. elegans,
fkh-9 is involved in several processes, including axon regeneration; determination of adult lifespan; and learning or memory.
Ovo-fkh-2 [Browse genome (BioProject PRJEB513)] [Search on AGR]
Onchocerca volvulus Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans
fkh-2. In C. elegans,
fkh-2 is involved in several processes, including nematode larval development; neuron differentiation; and non-motile cilium assembly.
SRAE_1000233900 [Browse genome (BioProject PRJEB125)] [Search on AGR]
Strongyloides ratti Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans
fkh-9. In C. elegans,
fkh-9 is involved in several processes, including axon regeneration; determination of adult lifespan; and learning or memory.
fkh-9 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including axon regeneration; determination of adult lifespan; and learning or memory. Acts upstream of or within ERAD pathway and defense response to other organism. Located in nucleus. Expressed in several structures, including intestine; neurons; pharyngeal-intestinal valve; rectal valve cell; and somatic nervous system.
PPA18100 [Browse genome (BioProject PRJNA12644)] [Search on AGR]
Pristionchus pacificus Predicted to enable DNA-binding transcription factor activity; hydrolase activity; and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is an ortholog of C. elegans F40B5.2 and
fkh-2. In C. elegans,
fkh-2 is involved in several processes, including nematode larval development; neuron differentiation; and non-motile cilium assembly.
kap-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Contributes to microtubule motor activity. Involved in intraciliary anterograde transport; negative regulation of non-motile cilium assembly; and positive regulation of non-motile cilium assembly. Located in ciliary transition zone and non-motile cilium. Part of axonemal heterotrimeric kinesin-II complex. Expressed in ciliated neurons. Is an ortholog of human KIFAP3 (kinesin associated protein 3).
sage [Search on AGR]
Drosophila melanogaster salivary gland-expressed bHLH (sage) is only expressed in embryonic salivary glands. The product of sage works with the product of fkh to activate expression of salivary gland specific gene products (secreted proteins and enzymes that modify the secreted proteins).
ify-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables protease binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including cortical granule exocytosis; nuclear division; and protein stabilization. Located in condensed chromosome; cytoplasm; and spindle microtubule. Expressed in germ cell.
T04F3.1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable transaminase activity. Predicted to be involved in amino acid metabolic process. Is an ortholog of human ACCS (1-aminocyclopropane-1-carboxylate synthase homolog (inactive)) and ACCSL (1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like).
ape-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables
p53 binding activity. Involved in negative regulation of apoptotic process. Predicted to be located in cytoplasm and nucleus. Expressed in several structures, including neurons and ventral nerve cord. Is an ortholog of human PPP1R13B (protein phosphatase 1 regulatory subunit 13B) and TP53BP2 (tumor protein
p53 binding protein 2).
sna-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable transcription coactivator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of core mediator complex and mediator complex. Expressed in several structures, including germ cell and somatic cell.
brd-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables ubiquitin protein ligase activity. Involved in DNA repair and protein ubiquitination. Part of BRCA1-BARD1 complex. Human ortholog(s) of this gene implicated in breast cancer and ovarian cancer. Is an ortholog of human BARD1 (BRCA1 associated RING domain 1).
asd-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables single-stranded RNA binding activity. Predicted to be involved in nervous system development and regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in cytoplasm and nucleus. Expressed in body wall musculature; intestine; nervous system; and vulval muscle. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; hypoplastic left heart syndrome; myotonic dystrophy type 1; and type 2 diabetes mellitus. Is an ortholog of human RBFOX1 (RNA binding
fox-1 homolog 1); RBFOX2 (RNA binding
fox-1 homolog 2); and RBFOX3 (RNA binding
fox-1 homolog 3).
git-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable GTPase activator activity and small GTPase binding activity. Involved in gonad morphogenesis and inductive cell migration. Located in hemidesmosome and presynaptic active zone. Human ortholog(s) of this gene implicated in Huntington's disease and attention deficit hyperactivity disorder. Is an ortholog of human GIT2 (GIT ArfGAP 2).
mpz-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables GTPase activating protein binding activity. Located in axon. Expressed in body wall musculature; nerve ring; neurons; and vulval muscle. Human ortholog(s) of this gene implicated in hydrocephalus. Is an ortholog of human MPDZ (multiple PDZ domain crumbs cell polarity complex component) and PATJ (PATJ crumbs cell polarity complex component).
ajm-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable cytoskeletal protein binding activity. Involved in cell-cell junction organization and embryo development. Located in apicolateral plasma membrane; cell-cell junction; and plasma membrane bounded cell projection. Expressed in several structures, including arcade cell and epithelial cell. Is an ortholog of human AJM1 (apical junction component 1 homolog).