- gck-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables mitogen-activated protein kinase binding activity and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of endocytic recycling; regulation of Golgi organization; and regulation of oocyte development. Located in cytoplasm and cytoplasmic side of apical plasma membrane. Used to study cerebral cavernous malformation. Is an ortholog of human STK26 (serine/threonine kinase 26).
- gck-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable MAP kinase kinase kinase kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to be located in cytoplasm. Expressed in several structures, including embryonic cell and vulval precursor cell. Used to study ciliopathy. Is an ortholog of human MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3) and MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5).
- gck-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in epithelial tube morphogenesis; hyperosmotic response; and multicellular organismal-level water homeostasis. Acts upstream of with a positive effect on positive regulation of gene expression. Located in cytoplasm. Expressed in body wall musculature; excretory system; hypodermis; oocyte; and spermatheca. Is an ortholog of human OXSR1 (oxidative stress responsive kinase 1) and STK39 (serine/threonine kinase 39).
- gck-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in phosphorylation. Predicted to be located in cytoplasm. Expressed in head and tail. Is an ortholog of human SLK (STE20 like kinase) and STK10 (serine/threonine kinase 10).
- hxk-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable fructokinase activity and glucokinase activity. Predicted to be involved in carbohydrate metabolic process; glucose 6-phosphate metabolic process; and intracellular glucose homeostasis. Predicted to be located in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Is an ortholog of human GCK (glucokinase).
- pros-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in glial cell development. Located in nucleus. Expressed in several structures, including labial sensillum and neuronal sheath cell. Is an ortholog of human PROX1 (prospero homeobox 1).
- mig-15 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable protein serine/threonine kinase activity. Involved in several processes, including dorsal/ventral axon guidance; nematode larval development; and regulation of GABAergic synaptic transmission. Predicted to be located in cytoplasm. Expressed in several structures, including QL; QR; body wall musculature; pharynx; and somatic nervous system. Used to study epilepsy. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive intellectual developmental disorder 54; gastrointestinal system cancer (multiple); and hepatitis B. Is an ortholog of human MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4); MINK1 (misshapen like kinase 1); and TNIK (TRAF2 and NCK interacting kinase).