Enables aconitate hydratase activity. Involved in tricarboxylic acid metabolic process. Located in cytosol. Expressed in seam cell. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is an ortholog of human ACO1 (aconitase 1).
Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in nuclear pore organization. Part of nuclear pore. Is an ortholog of human NDC1 (NDC1 transmembrane nucleoporin).
Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Is an ortholog of several human genes including SLC22A11 (solute carrier family 22 member 11); SLC22A14 (solute carrier family 22 member 14); and SLC22A4 (solute carrier family 22 member 4).
Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in acute kidney failure and rheumatoid arthritis. Is an ortholog of several human genes including SLC22A14 (solute carrier family 22 member 14); SLC22A2 (solute carrier family 22 member 2); and SLC22A4 (solute carrier family 22 member 4).
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and SUMO ligase activity. Involved in several processes, including meiotic metaphase I homologous chromosome alignment; protein sumoylation; and regulation of cellular response to stress. Located in metaphase plate. Part of chromatin. Expressed in motor neurons. Is an ortholog of human PIAS1 (protein inhibitor of activated STAT 1); PIAS2 (protein inhibitor of activated STAT 2); and PIAS3 (protein inhibitor of activated STAT 3).
Predicted to enable metal ion binding activity. Predicted to be involved in negative regulation of transcription elongation by RNA polymerase II. Predicted to be part of NELF complex.