hda-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in negative regulation of transcription by RNA polymerase II; receptor guanylyl cyclase signaling pathway; and regulation of neuron differentiation. Located in nucleus. Expressed in amphid neurons; body wall musculature; motor neurons; seam cell; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); gastrointestinal system cancer (multiple); and neurodegenerative disease (multiple). Is an ortholog of several human genes including HDAC4 (histone deacetylase 4); HDAC5 (histone deacetylase 5); and HDAC9 (histone deacetylase 9).