Involved in germline cell cycle switching, mitotic to meiotic cell cycle and resolution of meiotic recombination intermediates. Part of chromatin. Expressed in germ line; head; and tail.
Enables 3'-5' DNA helicase activity and enzyme binding activity. Involved in several processes, including determination of adult lifespan; meiotic nuclear division; and resolution of recombination intermediates. Located in chromosome and nucleus. Used to study Bloom syndrome. Human ortholog(s) of this gene implicated in Bloom syndrome. Is an ortholog of human BLM (BLM RecQ like helicase).
Enables DNA binding activity. Involved in regulation of centriole-centriole cohesion and synaptonemal complex assembly. Located in lateral element. Expressed in oocyte and spermatocyte. Is an ortholog of human HORMAD1 (HORMA domain containing 1) and HORMAD2 (HORMA domain containing 2).
Predicted to enable microtubule binding activity and structural molecule activity. Involved in nuclear chromosome segregation and organelle organization. Located in kinetochore. Part of Ndc80 complex. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); gastrointestinal system cancer (multiple); and oral cavity carcinoma in situ. Is an ortholog of human NUF2 (NUF2 component of NDC80 kinetochore complex).