- jun-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of RNA splicing; and response to starvation. Located in nucleus. Expressed in several structures, including excretory cell; hermaphrodite gonad; nervous system; pharyngeal-intestinal valve; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); gastrointestinal system cancer (multiple); and lymphoma (multiple). Is an ortholog of human JUN (Jun proto-oncogene, AP-1 transcription factor subunit); JUNB (JunB proto-oncogene, AP-1 transcription factor subunit); and JUND (JunD proto-oncogene, AP-1 transcription factor subunit).
- sek-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable JUN kinase kinase activity. Predicted to be involved in MAPK cascade. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); invasive ductal carcinoma; and prostate carcinoma in situ. Is an ortholog of human MAP2K4 (mitogen-activated protein kinase kinase 4).
- kgb-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables DEAD/H-box RNA helicase binding activity; JUN kinase activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including gamete generation; response to inorganic substance; and response to toxic substance. Located in cytoplasm. Expressed in several structures, including excretory cell; germ line; gonad; nerve ring; and tail ganglion.
- glh-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables DEAD/H-box RNA helicase binding activity; JUN kinase binding activity; and protein self-association. Predicted to be involved in cell differentiation and gamete generation. Located in P granule. Expressed in gonad. Is an ortholog of human DDX4 (DEAD-box helicase 4).
- jkk-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables JUN kinase kinase activity. Involved in hyperosmotic response and locomotion. Located in axon; cytoplasm; and neuronal cell body. Expressed in neurons. Human ortholog(s) of this gene implicated in colon adenocarcinoma; lung adenocarcinoma; and prostate carcinoma in situ. Is an ortholog of human MAP2K7 (mitogen-activated protein kinase kinase 7).
- vhp-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables JUN kinase phosphatase activity and MAP kinase tyrosine/serine/threonine phosphatase activity. Involved in several processes, including regulation of cellular response to stress; regulation of defense response to bacterium; and regulation of protein localization to nucleus. Acts upstream of with a negative effect on protein catabolic process. Predicted to be located in cytoplasm and nucleus. Is an ortholog of human DUSP16 (dual specificity phosphatase 16) and DUSP8 (dual specificity phosphatase 8).
- mek-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables JUN kinase kinase activity and SH2 domain binding activity. Involved in several processes, including gamete generation; response to metal ion; and stress-activated MAPK cascade. Predicted to be located in cytoplasm. Expressed in several structures, including ganglia; hermaphrodite gonad; intestine; nerve ring; and pharynx. Human ortholog(s) of this gene implicated in colon adenocarcinoma; lung adenocarcinoma; and prostate carcinoma in situ. Is an ortholog of human MAP2K7 (mitogen-activated protein kinase kinase 7).