sos-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable guanyl-nucleotide exchange factor activity. Involved in several processes, including epidermal growth factor receptor signaling pathway; female gamete generation; and positive regulation of vulval development. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 4; Noonan syndrome 9; and reproductive organ cancer (multiple). Is an ortholog of human SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1).
let-767 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables long-chain-fatty-acyl-CoA reductase activity and testosterone dehydrogenase [NAD(P)] activity. Involved in several processes, including female genitalia development; long-chain fatty acid biosynthetic process; and steroid metabolic process. Located in apical cortex and endoplasmic reticulum. Expressed in hypodermis; intestine; and pharynx. Used to study obesity. Human ortholog(s) of this gene implicated in 17-beta hydroxysteroid dehydrogenase 3 deficiency and Alzheimer's disease. Is an ortholog of human HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12).
let-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in several processes, including epithelial cell development; nematode larval development; and positive regulation of membrane permeability. Located in apical part of cell. Expressed in excretory system; hypodermis; rectal epithelial cell; and vulva.
let-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables mRNA 3'-UTR binding activity. Involved in several processes, including negative regulation of Ras protein signal transduction; negative regulation of gene expression; and regulation of development, heterochronic. Part of RISC complex. Expressed in several structures, including gonad; hypodermis; somatic nervous system; touch receptor neurons; and vulval precursor cell. Used to study cancer.
let-502 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable Rho-dependent protein serine/threonine kinase activity. Involved in several processes, including embryonic body morphogenesis; nematode larval development; and pharyngeal gland morphogenesis. Located in adherens junction; contractile fiber; and nucleus. Expressed in several structures, including P3.p hermaphrodite; Z2; Z3; gonad; and hypodermis. Is an ortholog of human ROCK1 (Rho associated coiled-coil containing protein kinase 1) and ROCK2 (Rho associated coiled-coil containing protein kinase 2).
let-92 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables DEAD/H-box RNA helicase binding activity. Involved in organelle organization. Located in several cellular components, including axonal growth cone; centrosome; and neuronal cell body. Part of protein phosphatase type 2A complex. Human ortholog(s) of this gene implicated in Parkinson's disease; congestive heart failure; and prostate cancer. Is an ortholog of human PPP2CA (protein phosphatase 2 catalytic subunit alpha) and PPP2CB (protein phosphatase 2 catalytic subunit beta).
let-754 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable adenylate kinase activity. Involved in negative regulation of protein kinase C signaling and regulation of establishment of cell polarity. Predicted to be located in mitochondrion. Expressed in head and tail. Human ortholog(s) of this gene implicated in reticular dysgenesis. Is an ortholog of human AK2 (adenylate kinase 2).
let-70 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Involved in programmed cell death involved in cell development; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in nucleus. Predicted to be part of ubiquitin ligase complex. Expressed in several structures, including P1; P2; linker cell; ventral ganglion; and ventral nerve cord. Is an ortholog of human UBE2D2 (ubiquitin conjugating enzyme E2 D2) and UBE2D3 (ubiquitin conjugating enzyme E2 D3).
let-858 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA binding activity. Involved in gastrulation and germ-line stem cell division. Located in germ cell nucleus and nucleoplasm. Part of chromatin. Expressed in somatic cell. Is an ortholog of human CWC22 (CWC22 spliceosome associated protein homolog).
let-418 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in embryonic digestive tract morphogenesis; negative regulation of transcription by RNA polymerase II; and negative regulation of vulval development. Part of RNA polymerase II transcription repressor complex. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; gonad; and somatic nervous system. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); lung adenocarcinoma; and lymphoma. Is an ortholog of human CHD3 (chromodomain helicase DNA binding protein 3).
let-711 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable molecular adaptor activity. Involved in several processes, including microtubule cytoskeleton organization; nematode larval development; and nuclear-transcribed mRNA poly(A) tail shortening. Located in cytoplasm. Part of CCR4-NOT complex. Expressed in germ line; gonad; and in male. Human ortholog(s) of this gene implicated in holoprosencephaly. Is an ortholog of human CNOT1 (CCR4-NOT transcription complex subunit 1).
let-413 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in several processes, including adherens junction assembly; embryonic digestive tract morphogenesis; and maintenance of epithelial cell apical/basal polarity. Located in basolateral plasma membrane. Expressed in epithelial cell; nerve ring; rectum; and spermatheca. Is an ortholog of human SCRIB (scribble planar cell polarity protein).
let-805 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable cytokine binding activity and cytokine receptor activity. Involved in hemidesmosome assembly. Located in hemidesmosome. Expressed in hypodermal cell; hypodermis; pharynx; touch receptor neurons; and uterine seam cell. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome and vesicoureteral reflux. Is an ortholog of human TNXB (tenascin XB).
let-60 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables GTP binding activity; phospholipase binding activity; and protein serine/threonine kinase binding activity. Involved in several processes, including learning or memory; positive regulation of receptor localization to synapse; and positive regulation of vulval development. Located in cell cortex. Expressed in several structures, including gonad; head neurons; pharyngeal muscle cell; vulval cell; and vulval precursor cell. Used to study RASopathy and prostate cancer. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; carcinoma (multiple); hematologic cancer (multiple); and malignant astrocytoma (multiple). Is an ortholog of human HRAS (HRas proto-oncogene, GTPase).
let-381 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables sequence-specific DNA binding activity. Involved in mesodermal cell fate specification; nematode larval development; and positive regulation of mesodermal cell fate specification. Located in nucleus. Expressed in M.dlp; M.drp; body wall muscle cell from M lineage; and coelomocyte. Human ortholog(s) of this gene implicated in persistent fetal circulation syndrome. Is an ortholog of human FOXF1 (forkhead box F1).
T26E4.7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Is affected by
let-60 based on microarray studies. Is predicted to encode a protein with the following domains: Protein of unknown function DUF273; Protein of unknown function, DUF273; and Nucleotide-diphospho-sugar transferases.
rog-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable fibroblast growth factor receptor binding activity and transmembrane receptor protein tyrosine kinase adaptor activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway. Predicted to be located in cytoplasm. Expressed in germ line. Human ortholog(s) of this gene implicated in renal cell carcinoma. Is an ortholog of human FRS3 (fibroblast growth factor receptor substrate 3).
let-268 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables UDP-glucose:glycoprotein glucosyltransferase activity. Involved in collagen biosynthetic process and protein glycosylation. Predicted to be located in endoplasmic reticulum. Expressed in GLR and body wall musculature. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome kyphoscoliotic type 1; hepatocellular carcinoma; and lung adenocarcinoma. Is an ortholog of human PLOD1 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 1).
let-630 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable rRNA binding activity and ribosomal small subunit binding activity. Predicted to be involved in mitochondrial translation. Predicted to be located in mitochondrion. Predicted to be part of ribonucleoprotein complex. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 51. Is an ortholog of human PTCD3 (pentatricopeptide repeat domain 3).
sli-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable SH3 domain binding activity; receptor tyrosine kinase binding activity; and ubiquitin protein ligase activity. Involved in negative regulation of vulval development. Predicted to be located in membrane raft and plasma membrane. Expressed in several structures, including anal depressor muscle; body wall musculature; distal tip cell; head; and intestine. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung squamous cell carcinoma. Is an ortholog of human CBL (Cbl proto-oncogene); CBLB (Cbl proto-oncogene B); and CBLC (Cbl proto-oncogene C).
let-49 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable transcription coregulator activity. Involved in embryo development and reproduction. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Is an ortholog of human MED7 (mediator complex subunit 7).
K02B2.6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in sensory neurons based on RNA-seq studies. Is affected by several genes including
daf-2;
let-60; and
eat-2 based on microarray and RNA-seq studies. Is affected by five chemicals including Tunicamycin; silicon dioxide nanoparticle; and resveratrol based on microarray studies.
let-653 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans A structural constituent of cuticle. Involved in several processes, including cuticle pattern formation; embryonic ectodermal digestive tract morphogenesis; and regulation of developmental process. Located in apical plasma membrane; extracellular space; and supramolecular fiber. Expressed in excretory duct cell; excretory socket cell; rectal epithelial cell; and vulval cell.
apc-11 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables ubiquitin-protein transferase activity. Involved in anaphase-promoting complex-dependent catabolic process; embryo development; and meiotic chromosome segregation. Predicted to be located in nucleus. Predicted to be part of anaphase-promoting complex. Expressed in germ line. Is an ortholog of human ANAPC11 (anaphase promoting complex subunit 11).
let-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans An extracellular matrix structural constituent conferring tensile strength. Involved in several processes, including embryo development; gonad morphogenesis; and regulation of distal tip cell migration. Located in basement membrane. Part of collagen type IV trimer. Expressed in several structures, including coelomocyte; egg-laying apparatus; rectal muscle; spermatheca; and tail. Human ortholog(s) of this gene implicated in several diseases, including X-linked Alport syndrome; X-linked deafness 6; and artery disease (multiple). Is an ortholog of human COL4A1 (collagen type IV alpha 1 chain); COL4A5 (collagen type IV alpha 5 chain); and COL4A6 (collagen type IV alpha 6 chain).
let-23 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables epidermal growth factor receptor activity. Involved in several processes, including determination of adult lifespan; positive regulation of vulval development; and reproductive structure development. Located in cell-cell junction and plasma membrane. Expressed in several structures, including apoptotic cell; egg-laying apparatus; excretory duct cell; head; and vulval precursor cell. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); hypertension (multiple); and reproductive organ cancer (multiple). Is an ortholog of human EGFR (epidermal growth factor receptor) and ERBB4 (erb-
b2 receptor tyrosine kinase 4).