mek-2

Caenorhabditis elegans

Enables protein serine/threonine/tyrosine kinase activity and scaffold protein binding activity. Involved in defense response to Gram-positive bacterium; intracellular signal transduction; and vulval development. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); cardiofaciocutaneous syndrome 3; and cardiofaciocutaneous syndrome 4. Is an ortholog of human MAP2K1 (mitogen-activated protein kinase kinase 1) and MAP2K2 (mitogen-activated protein kinase kinase 2).

let-635

Caenorhabditis elegans

let-984

Caenorhabditis elegans

let-532

Caenorhabditis elegans

let-855

Caenorhabditis elegans

let-556

Caenorhabditis elegans

let-506

Caenorhabditis elegans

let-88

Caenorhabditis elegans

let-528

Caenorhabditis elegans

let-536

Caenorhabditis elegans

let-55

Caenorhabditis elegans

let-86

Caenorhabditis elegans

let-524

Caenorhabditis elegans

let-639

Caenorhabditis elegans

let-853

Caenorhabditis elegans

let-50

Caenorhabditis elegans

let-559

Caenorhabditis elegans

let-59

Caenorhabditis elegans

let-555

Caenorhabditis elegans

let-158

Caenorhabditis elegans

let-427

Caenorhabditis elegans

let-560

Caenorhabditis elegans

let-424

Caenorhabditis elegans

let-469

Caenorhabditis elegans

let-146

Caenorhabditis elegans

let-809

Caenorhabditis elegans

let-410

Caenorhabditis elegans

let-551

Caenorhabditis elegans

let-815

Caenorhabditis elegans

let-840

Caenorhabditis elegans

let-156

Caenorhabditis elegans

let-422

Caenorhabditis elegans

let-460

Caenorhabditis elegans

let-818

Caenorhabditis elegans

let-837

Caenorhabditis elegans

let-467

Caenorhabditis elegans

let-831

Caenorhabditis elegans

let-836

Caenorhabditis elegans

let-123

Caenorhabditis elegans

let-140

Caenorhabditis elegans

let-155

Caenorhabditis elegans

let-816

Caenorhabditis elegans

let-306

Caenorhabditis elegans

let-405

Caenorhabditis elegans

let-656

Caenorhabditis elegans

let-614

Caenorhabditis elegans

let-908

Caenorhabditis elegans

let-71

Caenorhabditis elegans

let-48

Caenorhabditis elegans

let-510

Caenorhabditis elegans

let-573

Caenorhabditis elegans

let-987

Caenorhabditis elegans

let-441

Caenorhabditis elegans

let-57

Caenorhabditis elegans

let-826

Caenorhabditis elegans

let-359

Caenorhabditis elegans

let-476

Caenorhabditis elegans

let-473

Caenorhabditis elegans

let-308

Caenorhabditis elegans

let-371

Caenorhabditis elegans

let-40

Caenorhabditis elegans

let-10

Caenorhabditis elegans

let-15

Caenorhabditis elegans

let-247

Caenorhabditis elegans

let-270

Caenorhabditis elegans

let-360

Caenorhabditis elegans

let-369

Caenorhabditis elegans

let-96

Caenorhabditis elegans

let-66

Caenorhabditis elegans

let-437

Caenorhabditis elegans

let-250

Caenorhabditis elegans

let-259

Caenorhabditis elegans

let-351

Caenorhabditis elegans

let-187

Caenorhabditis elegans

let-192

Caenorhabditis elegans

let-239

Caenorhabditis elegans

let-241

Caenorhabditis elegans

let-266

Caenorhabditis elegans

let-68

Caenorhabditis elegans

let-248

Caenorhabditis elegans

let-254

Caenorhabditis elegans

let-361

Caenorhabditis elegans

let-6

Caenorhabditis elegans

Acts upstream of or within nematode larval development.

let-63

Caenorhabditis elegans

let-327

Caenorhabditis elegans

let-395

Caenorhabditis elegans

let-11

Caenorhabditis elegans

let-58

Caenorhabditis elegans

let-153

Caenorhabditis elegans

let-702

Caenorhabditis elegans

let-313

Caenorhabditis elegans

let-321

Caenorhabditis elegans

let-30

Caenorhabditis elegans

let-786

Caenorhabditis elegans

let-130

Caenorhabditis elegans

let-154

Caenorhabditis elegans

let-157

Caenorhabditis elegans

let-159

Caenorhabditis elegans

let-164

Caenorhabditis elegans

let-18

Caenorhabditis elegans

let-307

Caenorhabditis elegans

let-52

Caenorhabditis elegans

let-131

Caenorhabditis elegans

let-135

Caenorhabditis elegans

let-145

Caenorhabditis elegans

let-151

Caenorhabditis elegans

let-160

Caenorhabditis elegans

let-844

Caenorhabditis elegans

let-163

Caenorhabditis elegans

let-161

Caenorhabditis elegans

let-746

Caenorhabditis elegans

let-132

Caenorhabditis elegans

let-752

Caenorhabditis elegans

let-93

Caenorhabditis elegans

let-133

Caenorhabditis elegans

let-150

Caenorhabditis elegans

let-324

Caenorhabditis elegans

str-137

Caenorhabditis elegans

Is affected by let-60 based on microarray studies.

let-125

Caenorhabditis elegans

let-148

Caenorhabditis elegans

let-143

Caenorhabditis elegans

let-144

Caenorhabditis elegans

let-162

Caenorhabditis elegans

let-357

Caenorhabditis elegans

let-544

Caenorhabditis elegans

21ur-11786

Caenorhabditis elegans

Is affected by let-418 based on RNA-seq studies.

F02G3.5

Caenorhabditis elegans

Is affected by let-418 based on RNA-seq studies.

let-120

Caenorhabditis elegans

let-113

Caenorhabditis elegans

let-14

Caenorhabditis elegans

let-320

Caenorhabditis elegans

C47G2.16

Caenorhabditis elegans

Is affected by let-418 based on RNA-seq studies.

F52F12.14

Caenorhabditis elegans

Is affected by let-418 based on RNA-seq studies.

let-128

Caenorhabditis elegans

let-134

Caenorhabditis elegans

T04H1.11

Caenorhabditis elegans

Is affected by let-418 based on RNA-seq studies.

T05A6.8

Caenorhabditis elegans

Is affected by let-418 based on RNA-seq studies.

let-112

Caenorhabditis elegans

let-115

Caenorhabditis elegans

let-137

Caenorhabditis elegans

let-834

Caenorhabditis elegans

let-149

Caenorhabditis elegans

Y66A7AL.8

Caenorhabditis elegans

Is affected by let-418 based on RNA-seq studies.

let-109

Caenorhabditis elegans

let-121

Caenorhabditis elegans

let-138

Caenorhabditis elegans

let-332

Caenorhabditis elegans

let-35

Caenorhabditis elegans

let-548

Caenorhabditis elegans

let-51

Caenorhabditis elegans

let-549

Caenorhabditis elegans

let-571

Caenorhabditis elegans

C17H12.30

Caenorhabditis elegans

Is affected by let-418 based on RNA-seq studies.

F38A6.9

Caenorhabditis elegans

Is affected by let-418 based on RNA-seq studies.

let-438

Caenorhabditis elegans

W01C8.15

Caenorhabditis elegans

Is affected by let-418 based on RNA-seq studies.

let-136

Caenorhabditis elegans

let-139

Caenorhabditis elegans

let-142

Caenorhabditis elegans

let-345

Caenorhabditis elegans

let-584

Caenorhabditis elegans

let-204

Caenorhabditis elegans

let-205

Caenorhabditis elegans

let-206

Caenorhabditis elegans

let-367

Caenorhabditis elegans

let-409

Caenorhabditis elegans

let-508

Caenorhabditis elegans

let-618

Caenorhabditis elegans

let-201

Caenorhabditis elegans

let-202

Caenorhabditis elegans

let-430

Caenorhabditis elegans

let-433

Caenorhabditis elegans

let-550

Caenorhabditis elegans

let-638

Caenorhabditis elegans

let-9

Caenorhabditis elegans

let-334

Caenorhabditis elegans

let-350

Caenorhabditis elegans

Acts upstream of or within reproduction.

let-372

Caenorhabditis elegans

let-634

Caenorhabditis elegans

let-105

Caenorhabditis elegans

let-118

Caenorhabditis elegans

let-516

Caenorhabditis elegans

let-127

Caenorhabditis elegans

let-141

Caenorhabditis elegans

let-208

Caenorhabditis elegans

let-356

Caenorhabditis elegans

let-373

Caenorhabditis elegans

let-547

Caenorhabditis elegans

let-574

Caenorhabditis elegans

let-117

Caenorhabditis elegans

let-122

Caenorhabditis elegans

let-577

Caenorhabditis elegans

let-593

Caenorhabditis elegans

let-636

Caenorhabditis elegans

let-644

Caenorhabditis elegans

let-5

Caenorhabditis elegans

Acts upstream of or within nematode larval development.

let-111

Caenorhabditis elegans

let-505

Caenorhabditis elegans

let-586

Caenorhabditis elegans

let-587

Caenorhabditis elegans

let-600

Caenorhabditis elegans

let-106

Caenorhabditis elegans

let-353

Caenorhabditis elegans

let-578

Caenorhabditis elegans

let-582

Caenorhabditis elegans

let-628

Caenorhabditis elegans

let-640

Caenorhabditis elegans

let-203

Caenorhabditis elegans

let-207

Caenorhabditis elegans

let-183

Caenorhabditis elegans

let-184

Caenorhabditis elegans

let-186

Caenorhabditis elegans

let-978

Caenorhabditis elegans

let-102

Caenorhabditis elegans

let-374

Caenorhabditis elegans

let-507

Caenorhabditis elegans

let-511

Caenorhabditis elegans

let-572

Caenorhabditis elegans

let-579

Caenorhabditis elegans

let-589

Caenorhabditis elegans

let-179

Caenorhabditis elegans

let-182

Caenorhabditis elegans

let-464

Caenorhabditis elegans

let-515

Caenorhabditis elegans

let-85

Caenorhabditis elegans

let-852

Caenorhabditis elegans

let-188

Caenorhabditis elegans

let-190

Caenorhabditis elegans

let-408

Caenorhabditis elegans

let-406

Caenorhabditis elegans

let-452

Caenorhabditis elegans

let-619

Caenorhabditis elegans

let-649

Caenorhabditis elegans

let-180

Caenorhabditis elegans

let-185

Caenorhabditis elegans

let-189

Caenorhabditis elegans

let-191

Caenorhabditis elegans

let-193

Caenorhabditis elegans

let-463

Caenorhabditis elegans

let-583

Caenorhabditis elegans

let-590

Caenorhabditis elegans

let-592

Caenorhabditis elegans

let-609

Caenorhabditis elegans

let-172

Caenorhabditis elegans

srw-27

Caenorhabditis elegans

Is affected by ain-1 and let-60 based on microarray studies.

let-615

Caenorhabditis elegans

let-650

Caenorhabditis elegans

let-518

Caenorhabditis elegans

21ur-10927

Caenorhabditis elegans

Is affected by let-418 and hlh-26 based on RNA-seq studies.

21ur-3437

Caenorhabditis elegans

Is affected by chd-3 and let-418 based on RNA-seq studies.

21ur-9906

Caenorhabditis elegans

Is affected by chd-3 and let-418 based on RNA-seq studies.

F54B11.13

Caenorhabditis elegans

Is affected by chd-3 and let-418 based on RNA-seq studies.

let-986

Caenorhabditis elegans

T05A6.15

Caenorhabditis elegans

Is affected by cep-1 and let-418 based on RNA-seq studies.

let-514

Caenorhabditis elegans

let-580

Caenorhabditis elegans

let-588

Caenorhabditis elegans

let-472

Caenorhabditis elegans

let-622

Caenorhabditis elegans

let-170

Caenorhabditis elegans

W01A11.18

Caenorhabditis elegans

Is affected by chd-3 and let-418 based on RNA-seq studies.

W07E11.7

Caenorhabditis elegans

Is affected by chd-3 and let-418 based on RNA-seq studies.

Y38C1AA.16

Caenorhabditis elegans

Is affected by chd-3 and let-418 based on RNA-seq studies.

ZC190.12

Caenorhabditis elegans

Is affected by let-418 and dlc-1 based on RNA-seq studies.

ZK377.6

Caenorhabditis elegans

Is affected by chd-3 and let-418 based on RNA-seq studies.

let-126

Caenorhabditis elegans

let-624

Caenorhabditis elegans

let-625

Caenorhabditis elegans

let-626

Caenorhabditis elegans

let-820

Caenorhabditis elegans

21ur-7128

Caenorhabditis elegans

Is affected by chd-3 and let-418 based on RNA-seq studies.

C45E5.53

Caenorhabditis elegans

Is affected by let-418 and hlh-26 based on RNA-seq studies.

K08A8.10

Caenorhabditis elegans

Is affected by cep-1 and let-418 based on RNA-seq studies.

let-985

Caenorhabditis elegans

Y65A5A.25

Caenorhabditis elegans

Is affected by cep-1 and let-418 based on RNA-seq studies.

let-107

Caenorhabditis elegans

let-119

Caenorhabditis elegans

let-352

Caenorhabditis elegans

let-613

Caenorhabditis elegans

let-623

Caenorhabditis elegans

let-627

Caenorhabditis elegans

let-629

Caenorhabditis elegans

let-709

Caenorhabditis elegans

let-375

Caenorhabditis elegans

let-621

Caenorhabditis elegans

let-647

Caenorhabditis elegans

21ur-279

Caenorhabditis elegans

Is affected by chd-3 and let-418 based on RNA-seq studies.

F56F10.8

Caenorhabditis elegans

Is affected by let-418 and met-2 based on RNA-seq studies.

let-983

Caenorhabditis elegans

Y38F1A.13

Caenorhabditis elegans

Is affected by chd-3 and let-418 based on RNA-seq studies.

Y59A8B.31

Caenorhabditis elegans

Is affected by chd-3 and let-418 based on RNA-seq studies.

let-110

Caenorhabditis elegans

let-546

Caenorhabditis elegans

let-632

Caenorhabditis elegans

let-642

Caenorhabditis elegans

let-704

Caenorhabditis elegans

let-830

Caenorhabditis elegans

let-38

Caenorhabditis elegans

let-767

Caenorhabditis elegans

Enables long-chain-fatty-acyl-CoA reductase activity and testosterone dehydrogenase [NAD(P)] activity. Involved in several processes, including female genitalia development; long-chain fatty acid biosynthetic process; and steroid metabolic process. Located in apical cortex and endoplasmic reticulum. Expressed in hypodermis; intestine; and pharynx. Used to study obesity. Human ortholog(s) of this gene implicated in 17-beta hydroxysteroid dehydrogenase 3 deficiency and Alzheimer's disease. Is an ortholog of human HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12).

21ur-15259

Caenorhabditis elegans

Is affected by chd-3 and let-418 based on RNA-seq studies.

F11D5.8

Caenorhabditis elegans

Is affected by chd-3 and let-418 based on RNA-seq studies.

F35D2.8

Caenorhabditis elegans

Is affected by cep-1 and let-418 based on RNA-seq studies.

let-44

Caenorhabditis elegans

T09E8.6

Caenorhabditis elegans

Is affected by let-418 and dlc-1 based on RNA-seq studies.

T13B5.t1

Caenorhabditis elegans

Is affected by chd-3 and let-418 based on RNA-seq studies.

let-706

Caenorhabditis elegans

let-810

Caenorhabditis elegans

let-116

Caenorhabditis elegans

let-633

Caenorhabditis elegans

let-643

Caenorhabditis elegans

let-645

Caenorhabditis elegans

let-648

Caenorhabditis elegans

let-712

Caenorhabditis elegans

let-827

Caenorhabditis elegans

let-175

Caenorhabditis elegans

let-176

Caenorhabditis elegans

let-700

Caenorhabditis elegans

let-814

Caenorhabditis elegans

let-819

Caenorhabditis elegans

let-114

Caenorhabditis elegans

let-637

Caenorhabditis elegans

let-501

Caenorhabditis elegans

let-707

Caenorhabditis elegans

let-710

Caenorhabditis elegans

srt-71

Caenorhabditis elegans

Is affected by mir-34; eri-1; and let-60 based on microarray studies.

let-641

Caenorhabditis elegans

let-459

Caenorhabditis elegans

let-598

Caenorhabditis elegans

F46F3.18

Caenorhabditis elegans

Is affected by chd-3; let-418; and dlc-1 based on RNA-seq studies.

K04G2.14

Caenorhabditis elegans

Is affected by chd-3; let-418; and dlc-1 based on RNA-seq studies.

let-312

Caenorhabditis elegans

let-660

Caenorhabditis elegans

ZC504.9

Caenorhabditis elegans

Is affected by chd-3; let-418; and met-2 based on RNA-seq studies.

let-444

Caenorhabditis elegans

let-253

Caenorhabditis elegans

F10C2.12

Caenorhabditis elegans

Is affected by chd-3; let-418; and dlc-1 based on RNA-seq studies.

F10D7.8

Caenorhabditis elegans

Is affected by cep-1; chd-3; and let-418 based on RNA-seq studies.

F46F2.9

Caenorhabditis elegans

Is affected by chd-3; let-418; and dlc-1 based on RNA-seq studies.

K11D9.8

Caenorhabditis elegans

Is affected by cep-1; chd-3; and let-418 based on RNA-seq studies.

let-705

Caenorhabditis elegans

Y42H9B.10

Caenorhabditis elegans

Is affected by chd-3; let-418; and lpd-3 based on RNA-seq studies.

ZC308.6

Caenorhabditis elegans

Is affected by chd-3; let-418; and dlc-1 based on RNA-seq studies.

let-99

Caenorhabditis elegans

Involved in establishment of mitotic spindle orientation. Located in cell cortex. Expressed in embryonic cell.

let-470

Caenorhabditis elegans

str-53

Caenorhabditis elegans

Is affected by wdr-23 and let-60 based on RNA-seq and microarray studies.

C16C2.10

Caenorhabditis elegans

Is affected by cep-1; chd-3; and let-418 based on RNA-seq studies.

F18A11.8

Caenorhabditis elegans

Is affected by chd-3; let-418; and dlc-1 based on RNA-seq studies.

F52B10.6

Caenorhabditis elegans

Is affected by cep-1; chd-3; and let-418 based on RNA-seq studies.

let-252

Caenorhabditis elegans

let-447

Caenorhabditis elegans

let-237

Caenorhabditis elegans

Acts upstream of or within embryo development.

let-454

Caenorhabditis elegans

R07E5.16

Caenorhabditis elegans

Is affected by mett-10; let-418; and dcp-66 based on RNA-seq studies.

Y42H9B.9

Caenorhabditis elegans

Is affected by cep-1; chd-3; and let-418 based on RNA-seq studies.

let-620

Caenorhabditis elegans

let-4

Caenorhabditis elegans

Involved in several processes, including epithelial cell development; nematode larval development; and positive regulation of membrane permeability. Located in apical part of cell. Expressed in excretory system; hypodermis; rectal epithelial cell; and vulva.

let-420

Caenorhabditis elegans

let-100

Caenorhabditis elegans

F11D5.16

Caenorhabditis elegans

Is affected by cep-1; let-418; and daf-2 based on RNA-seq and microarray studies.

let-421

Caenorhabditis elegans

C39E9.18

Caenorhabditis elegans

Is affected by spt-16; sir-2.1; and let-60 based on RNA-seq and microarray studies.

anr-2

Caenorhabditis elegans

Is affected by several genes including let-418; mrps-5; and cox-5B based on RNA-seq studies.

C50B6.13

Caenorhabditis elegans

Is affected by several genes including eat-2; let-418; and adr-1 based on RNA-seq studies.

C54D1.9

Caenorhabditis elegans

Is affected by several genes including cep-1; let-418; and chd-3 based on RNA-seq studies.

T25D3.5

Caenorhabditis elegans

Is affected by several genes including cep-1; let-418; and mrps-5 based on RNA-seq studies.

let-1

Caenorhabditis elegans

Acts upstream of or within embryo development and nematode larval development.

C36F7.15

Caenorhabditis elegans

Enriched in neurons based on RNA-seq studies. Is affected by let-418 based on RNA-seq studies.

let-557

Caenorhabditis elegans

T01A4.6

Caenorhabditis elegans

Is affected by several genes including cep-1; let-418; and dlc-1 based on RNA-seq studies.

T12B3.8

Caenorhabditis elegans

Is affected by several genes including lag-1; let-418; and chd-3 based on RNA-seq studies.

Y38C1BA.5

Caenorhabditis elegans

Enriched in neurons based on RNA-seq studies. Is affected by let-418 based on RNA-seq studies.

let-442

Caenorhabditis elegans

21ur-15575

Caenorhabditis elegans

Is affected by several genes including set-2; let-418; and smn-1 based on RNA-seq studies.

K03H4.3

Caenorhabditis elegans

Is affected by several genes including cep-1; let-418; and dlc-1 based on RNA-seq studies.

let-173

Caenorhabditis elegans

T28B11.12

Caenorhabditis elegans

Is affected by several genes including cep-1; let-418; and dlc-1 based on RNA-seq studies.

21ur-3110

Caenorhabditis elegans

Is affected by several genes including set-2; let-418; and chd-3 based on RNA-seq studies.

linc-39

Caenorhabditis elegans

Is affected by several genes including rrf-3; set-2; and let-418 based on RNA-seq studies.

W06H8.15

Caenorhabditis elegans

Is affected by several genes including cep-1; hpl-2; and let-418 based on RNA-seq studies.

let-346

Caenorhabditis elegans

let-87

Caenorhabditis elegans

let-7

Caenorhabditis elegans

Enables mRNA 3'-UTR binding activity. Involved in several processes, including negative regulation of Ras protein signal transduction; negative regulation of gene expression; and regulation of development, heterochronic. Part of RISC complex. Expressed in several structures, including gonad; hypodermis; somatic nervous system; touch receptor neurons; and vulval precursor cell. Used to study cancer.

C04D8.2

Caenorhabditis elegans

Is affected by several genes including daf-2; let-418; and dlc-1 based on RNA-seq and microarray studies.

C45B2.18

Caenorhabditis elegans

Is affected by let-418 based on RNA-seq studies. Is affected by silicon dioxide nanoparticle based on microarray studies.

srh-280

Caenorhabditis elegans

Is affected by several genes including let-60; sir-2.1; and qui-1 based on RNA-seq and microarray studies.

srz-73

Caenorhabditis elegans

Is affected by several genes including let-60; pgl-1; and glh-1 based on RNA-seq and microarray studies.

let-659

Caenorhabditis elegans

let-502

Caenorhabditis elegans

Predicted to enable Rho-dependent protein serine/threonine kinase activity. Involved in several processes, including embryonic body morphogenesis; nematode larval development; and pharyngeal gland morphogenesis. Located in adherens junction; contractile fiber; and nucleus. Expressed in several structures, including P3.p hermaphrodite; Z2; Z3; gonad; and hypodermis. Is an ortholog of human ROCK1 (Rho associated coiled-coil containing protein kinase 1) and ROCK2 (Rho associated coiled-coil containing protein kinase 2).

F22E10.6

Caenorhabditis elegans

Is affected by several genes including daf-2; let-418; and chd-3 based on RNA-seq and microarray studies.

let-558

Caenorhabditis elegans

srx-72

Caenorhabditis elegans

Is affected by several genes including clk-1; let-418; and adr-1 based on microarray and RNA-seq studies.

AC8.6

Caenorhabditis elegans

Is affected by several genes including daf-16; let-60; and sir-2.1 based on microarray and RNA-seq studies.

F23H12.21

Caenorhabditis elegans

Is affected by several genes including set-2; let-418; and hda-2 based on RNA-seq and microarray studies.

F46F3.21

Caenorhabditis elegans

Is affected by several genes including eat-2; cep-1; and let-418 based on RNA-seq and microarray studies.

K10C3.12

Caenorhabditis elegans

Is affected by several genes including daf-2; cep-1; and let-418 based on RNA-seq and microarray studies.

let-92

Caenorhabditis elegans

Enables DEAD/H-box RNA helicase binding activity. Involved in organelle organization. Located in several cellular components, including axonal growth cone; centrosome; and neuronal cell body. Part of protein phosphatase type 2A complex. Human ortholog(s) of this gene implicated in Parkinson's disease; congestive heart failure; and prostate cancer. Is an ortholog of human PPP2CA (protein phosphatase 2 catalytic subunit alpha) and PPP2CB (protein phosphatase 2 catalytic subunit beta).

C07G1.11

Caenorhabditis elegans

Is affected by chd-3 and let-418 based on RNA-seq studies. Is affected by Oligosaccharides based on microarray studies.

F07C3.11

Caenorhabditis elegans

Is affected by chd-3 and let-418 based on RNA-seq studies. Is affected by Tunicamycin based on microarray studies.

K08C9.10

Caenorhabditis elegans

Is affected by several genes including let-7; gld-1; and pmt-2 based on proteomic; microarray; and RNA-seq studies.

K10D6.8

Caenorhabditis elegans

Enriched in neurons based on RNA-seq studies. Is affected by chd-3 and let-418 based on RNA-seq studies.

let-754

Caenorhabditis elegans

Predicted to enable adenylate kinase activity. Involved in negative regulation of protein kinase C signaling and regulation of establishment of cell polarity. Predicted to be located in mitochondrion. Expressed in head and tail. Human ortholog(s) of this gene implicated in reticular dysgenesis. Is an ortholog of human AK2 (adenylate kinase 2).

H21P03.8

Caenorhabditis elegans

Enriched in neurons based on RNA-seq studies. Is affected by chd-3 and let-418 based on RNA-seq studies.

K10D6.17

Caenorhabditis elegans

Is affected by chd-3 and let-418 based on RNA-seq studies. Is affected by Tunicamycin based on microarray studies.

let-70

Caenorhabditis elegans

Enables ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Involved in programmed cell death involved in cell development; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in nucleus. Predicted to be part of ubiquitin ligase complex. Expressed in several structures, including P1; P2; linker cell; ventral ganglion; and ventral nerve cord. Is an ortholog of human UBE2D2 (ubiquitin conjugating enzyme E2 D2) and UBE2D3 (ubiquitin conjugating enzyme E2 D3).

let-858

Caenorhabditis elegans

Predicted to enable RNA binding activity. Involved in gastrulation and germ-line stem cell division. Located in germ cell nucleus and nucleoplasm. Part of chromatin. Expressed in somatic cell. Is an ortholog of human CWC22 (CWC22 spliceosome associated protein homolog).

21ur-2200

Caenorhabditis elegans

Enriched in sensory neurons based on RNA-seq studies. Is affected by chd-3 and let-418 based on RNA-seq studies.

srab-15

Caenorhabditis elegans

Is affected by let-418; hpl-2; and etr-1 based on RNA-seq studies. Is affected by Diazinon based on microarray studies.

F18E2.12

Caenorhabditis elegans

Enriched in neurons based on RNA-seq studies. Is affected by chd-3; let-418; and etr-1 based on RNA-seq studies.

linc-121

Caenorhabditis elegans

Is affected by chd-3; let-418; and sin-3 based on RNA-seq studies. Is affected by Tunicamycin based on microarray studies.

srz-88

Caenorhabditis elegans

Is affected by qui-1 and let-60 based on RNA-seq and microarray studies. Is affected by resveratrol based on microarray studies.

F46C8.9

Caenorhabditis elegans

Is affected by chd-3 and let-418 based on RNA-seq studies. Is affected by iron oxide nanoparticle based on microarray studies.

Y26G10.3

Caenorhabditis elegans

Enriched in male based on RNA-seq studies. Is affected by dpy-21 and let-60 based on RNA-seq and microarray studies.

let-479

Caenorhabditis elegans

let-981

Caenorhabditis elegans

srz-57

Caenorhabditis elegans

Is affected by let-60; daf-2; and daf-16 based on microarray studies. Is affected by resveratrol and Sirolimus based on microarray studies.

let-418

Caenorhabditis elegans

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in embryonic digestive tract morphogenesis; negative regulation of transcription by RNA polymerase II; and negative regulation of vulval development. Part of RNA polymerase II transcription repressor complex. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; gonad; and somatic nervous system. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); lung adenocarcinoma; and lymphoma. Is an ortholog of human CHD3 (chromodomain helicase DNA binding protein 3).

srb-4

Caenorhabditis elegans

Is affected by hmg-4; let-418; and dcp-66 based on RNA-seq studies. Is affected by resveratrol and Sirolimus based on microarray studies.

T09F5.13

Caenorhabditis elegans

Is affected by alg-1; etr-1; and let-60 based on RNA-seq and microarray studies. Is affected by Cholestanol based on microarray studies.

let-711

Caenorhabditis elegans

Predicted to enable molecular adaptor activity. Involved in several processes, including microtubule cytoskeleton organization; nematode larval development; and nuclear-transcribed mRNA poly(A) tail shortening. Located in cytoplasm. Part of CCR4-NOT complex. Expressed in germ line; gonad; and in male. Human ortholog(s) of this gene implicated in holoprosencephaly. Is an ortholog of human CNOT1 (CCR4-NOT transcription complex subunit 1).

srh-84

Caenorhabditis elegans

Is affected by etr-1; sir-2.1; and let-60 based on RNA-seq and microarray studies. Is affected by resveratrol based on microarray studies.

F56A11.9

Caenorhabditis elegans

Is affected by chd-3; let-418; and dlc-1 based on RNA-seq studies. Is affected by silicon dioxide nanoparticle based on microarray studies.

R105.4

Caenorhabditis elegans

Is affected by daf-2; unc-30; and let-418 based on microarray and RNA-seq studies. Is affected by paraquat based on RNA-seq studies.

srh-160

Caenorhabditis elegans

Is affected by several genes including daf-2; let-60; and sir-2.1 based on microarray studies. Is affected by Sirolimus based on microarray studies.

srz-92

Caenorhabditis elegans

Is affected by etr-1 and let-60 based on RNA-seq and microarray studies. Is affected by dafa#1 and Sirolimus based on microarray studies.

T19A5.8

Caenorhabditis elegans

Is affected by several genes including let-418; dlc-1; and mrps-5 based on RNA-seq studies. Is affected by Oligosaccharides based on microarray studies.

ZC53.4

Caenorhabditis elegans

Enriched in AFD based on RNA-seq studies. Is affected by several genes including csr-1; set-2; and let-418 based on RNA-seq studies.

F26F12.19

Caenorhabditis elegans

Enriched in neurons based on RNA-seq studies. Is affected by let-418 based on RNA-seq studies. Is affected by Oligosaccharides based on microarray studies.

let-413

Caenorhabditis elegans

Involved in several processes, including adherens junction assembly; embryonic digestive tract morphogenesis; and maintenance of epithelial cell apical/basal polarity. Located in basolateral plasma membrane. Expressed in epithelial cell; nerve ring; rectum; and spermatheca. Is an ortholog of human SCRIB (scribble planar cell polarity protein).

F46F3.14

Caenorhabditis elegans

Enriched in germ line based on RNA-seq studies. Is affected by several genes including let-418; dlc-1; and mys-1 based on RNA-seq studies.

let-805

Caenorhabditis elegans

Predicted to enable cytokine binding activity and cytokine receptor activity. Involved in hemidesmosome assembly. Located in hemidesmosome. Expressed in hypodermal cell; hypodermis; pharynx; touch receptor neurons; and uterine seam cell. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome and vesicoureteral reflux. Is an ortholog of human TNXB (tenascin XB).

linc-13

Caenorhabditis elegans

Is affected by several genes including set-2; let-418; and sin-3 based on RNA-seq studies. Is affected by stavudine based on RNA-seq studies.

T28F3.7

Caenorhabditis elegans

Enriched in sensory neurons based on RNA-seq studies. Is affected by several genes including eat-2; dpy-21; and let-418 based on RNA-seq studies.

let-60

Caenorhabditis elegans

Enables GTP binding activity; phospholipase binding activity; and protein serine/threonine kinase binding activity. Involved in several processes, including learning or memory; positive regulation of receptor localization to synapse; and positive regulation of vulval development. Located in cell cortex. Expressed in several structures, including gonad; head neurons; pharyngeal muscle cell; vulval cell; and vulval precursor cell. Used to study RASopathy and prostate cancer. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; carcinoma (multiple); hematologic cancer (multiple); and malignant astrocytoma (multiple). Is an ortholog of human HRAS (HRas proto-oncogene, GTPase).

srw-80

Caenorhabditis elegans

Enriched in head mesodermal cell based on RNA-seq studies. Is affected by several genes including let-418; adr-1; and etr-1 based on RNA-seq studies.

srh-262

Caenorhabditis elegans

Is affected by several genes including sir-2.1; clk-1; and let-418 based on microarray and RNA-seq studies. Is affected by Sirolimus based on microarray studies.

W04D2.8

Caenorhabditis elegans

Is affected by chd-3; let-418; and eat-2 based on RNA-seq and microarray studies. Is affected by multi-walled carbon nanotube based on RNA-seq studies.

clec-237

Caenorhabditis elegans

Is affected by several genes including daf-2; let-60; and sir-2.1 based on microarray and RNA-seq studies. Is affected by aldicarb based on microarray studies.

srh-107

Caenorhabditis elegans

Is affected by several genes including eat-2; let-418; and chd-3 based on RNA-seq and microarray studies. Is affected by dibromoacetic acid based on microarray studies.

F46C3.5

Caenorhabditis elegans

Is affected by several genes including daf-2; let-418; and chd-3 based on RNA-seq and microarray studies. Is affected by 1-methylnicotinamide based on RNA-seq studies.

srh-254

Caenorhabditis elegans

Is affected by lpd-3; sir-2.1; and let-60 based on RNA-seq and microarray studies. Is affected by resveratrol and adsorbable organic bromine compound based on microarray studies.

Y113G7A.2

Caenorhabditis elegans

Is affected by several genes including daf-16; eat-2; and let-418 based on RNA-seq studies. Is affected by Rifampin; Psoralens; and Sirolimus based on RNA-seq studies.

srbc-35

Caenorhabditis elegans

Is affected by several genes including let-60; pgl-1; and glh-1 based on RNA-seq and microarray studies. Is affected by resveratrol and Sirolimus based on microarray studies.

Y105C5A.31

Caenorhabditis elegans

Is affected by chd-3; let-418; and eat-2 based on RNA-seq studies. Is affected by five chemicals including Psoralens; allantoin; and metformin based on RNA-seq studies.

Y42H9B.7

Caenorhabditis elegans

Is affected by several genes including daf-2; eat-2; and let-418 based on RNA-seq and microarray studies. Is affected by silicon dioxide nanoparticle based on microarray studies.

let-381

Caenorhabditis elegans

Enables sequence-specific DNA binding activity. Involved in mesodermal cell fate specification; nematode larval development; and positive regulation of mesodermal cell fate specification. Located in nucleus. Expressed in M.dlp; M.drp; body wall muscle cell from M lineage; and coelomocyte. Human ortholog(s) of this gene implicated in persistent fetal circulation syndrome. Is an ortholog of human FOXF1 (forkhead box F1).

srw-132

Caenorhabditis elegans

Is affected by several genes including let-60; sir-2.1; and clk-1 based on microarray; tiling array; and RNA-seq studies. Is affected by aldicarb based on microarray studies.

C36E8.6

Caenorhabditis elegans

Enriched in GABAergic neurons based on RNA-seq studies. Is affected by several genes including drh-3; let-418; and ubc-9 based on tiling array; microarray; and RNA-seq studies.

F18A1.10

Caenorhabditis elegans

Enriched in sensory neurons and somatic gonad precursor based on RNA-seq studies. Is affected by several genes including let-418; dlc-1; and chd-3 based on RNA-seq studies.

C33E10.7

Caenorhabditis elegans

Is affected by several genes including daf-2; eat-2; and let-418 based on RNA-seq and microarray studies. Is affected by metformin; Sirolimus; and Rifampin based on RNA-seq studies.

K03E5.9

Caenorhabditis elegans

Is affected by several genes including daf-2; sma-4; and let-418 based on RNA-seq and microarray studies. Is affected by stavudine; Doxycycline; and paraquat based on RNA-seq studies.

rac-3

Caenorhabditis elegans

Is affected by several genes including let-60; eat-2; and clk-1 based on microarray and RNA-seq studies. Is affected by Alovudine and Sirolimus based on RNA-seq and microarray studies.

T05A6.5

Caenorhabditis elegans

Is affected by several genes including let-60; sir-2.1; and clk-1 based on tiling array; microarray; and RNA-seq studies. Is affected by adsorbable organic bromine compound based on microarray studies.

Y57G11C.1143

Caenorhabditis elegans

Is affected by several genes including aak-2; let-418; and aak-1 based on RNA-seq studies. Is affected by four chemicals including Rifampin; Psoralens; and Sirolimus based on RNA-seq studies.

srz-21

Caenorhabditis elegans

Is affected by several genes including let-60; eat-2; and sir-2.1 based on microarray and RNA-seq studies. Is affected by Chlorpyrifos and adsorbable organic bromine compound based on microarray studies.

T26E4.7

Caenorhabditis elegans

Is affected by let-60 based on microarray studies. Is predicted to encode a protein with the following domains: Protein of unknown function DUF273; Protein of unknown function, DUF273; and Nucleotide-diphospho-sugar transferases.

srz-76

Caenorhabditis elegans

Enriched in NSM and neurons based on tiling array and RNA-seq studies. Is affected by several genes including let-60; clk-1; and drh-3 based on tiling array; microarray; and RNA-seq studies.

T26E3.11

Caenorhabditis elegans

Is affected by several genes including daf-2; eat-2; and let-418 based on RNA-seq and microarray studies. Is affected by five chemicals including rotenone; Psoralens; and allantoin based on RNA-seq studies.

F02E9.8

Caenorhabditis elegans

Is affected by several genes including eat-2; let-418; and dlc-1 based on RNA-seq studies. Is affected by six chemicals including Psoralens; allantoin; and metformin based on RNA-seq and microarray studies.

Y57G11B.4

Caenorhabditis elegans

Is affected by several genes including ain-1; let-418; and dcp-66 based on RNA-seq and microarray studies. Is affected by five chemicals including Psoralens; allantoin; and metformin based on RNA-seq studies.

T10D4.11

Caenorhabditis elegans

Is affected by several genes including let-60; sir-2.1; and tdp-1 based on microarray studies. Is predicted to encode a protein with the following domains: TRA-1 regulated and TRA-1 regulated protein R03H10.4.

Y57E12B.10

Caenorhabditis elegans

Is affected by several genes including let-418; qui-1; and pmt-2 based on RNA-seq and microarray studies. Is affected by five chemicals including Psoralens; allantoin; and Sirolimus based on RNA-seq studies.

K08D10.13

Caenorhabditis elegans

Is affected by several genes including set-2; let-418; and chd-3 based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: ShK domain-like and ShKT domain.

rog-1

Caenorhabditis elegans

Predicted to enable fibroblast growth factor receptor binding activity and transmembrane receptor protein tyrosine kinase adaptor activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway. Predicted to be located in cytoplasm. Expressed in germ line. Human ortholog(s) of this gene implicated in renal cell carcinoma. Is an ortholog of human FRS3 (fibroblast growth factor receptor substrate 3).

ZK666.4

Caenorhabditis elegans

Is affected by several genes including daf-2; let-60; and rrf-3 based on tiling array; RNA-seq; and microarray studies. Is affected by four chemicals including hydrogen sulfide; Tunicamycin; and cadmium based on microarray studies.

C29E4.11

Caenorhabditis elegans

Is affected by several genes including let-60; sir-2.1; and isp-1 based on RNA-seq and microarray studies. Is affected by five chemicals including Quercetin; Hydrolyzable Tannins; and Humic Substances based on microarray studies.

E02H4.8

Caenorhabditis elegans

Enriched in neurons based on RNA-seq studies. Is affected by several genes including let-60; sir-2.1; and sek-1 based on RNA-seq and microarray studies. Is affected by rotenone based on RNA-seq studies.

math-2

Caenorhabditis elegans

Enriched in NSM based on tiling array studies. Is affected by several genes including mex-1; let-418; and chd-3 based on tiling array and RNA-seq studies. Is affected by resveratrol based on microarray studies.

let-268

Caenorhabditis elegans

Enables UDP-glucose:glycoprotein glucosyltransferase activity. Involved in collagen biosynthetic process and protein glycosylation. Predicted to be located in endoplasmic reticulum. Expressed in GLR and body wall musculature. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome kyphoscoliotic type 1; hepatocellular carcinoma; and lung adenocarcinoma. Is an ortholog of human PLOD1 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 1).

Y74C9A.9

Caenorhabditis elegans

Enriched in AVK and germ line based on RNA-seq studies. Is affected by several genes including unc-30; atfs-1; and let-418 based on RNA-seq studies. Is affected by Sirolimus based on RNA-seq studies.

let-552

Caenorhabditis elegans

C43D7.11

Caenorhabditis elegans

Is affected by several genes including daf-2; eat-2; and let-418 based on RNA-seq and microarray studies. Is affected by six chemicals including multi-walled carbon nanotube; Psoralens; and allantoin based on RNA-seq studies.

let-630

Caenorhabditis elegans

Predicted to enable rRNA binding activity and ribosomal small subunit binding activity. Predicted to be involved in mitochondrial translation. Predicted to be located in mitochondrion. Predicted to be part of ribonucleoprotein complex. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 51. Is an ortholog of human PTCD3 (pentatricopeptide repeat domain 3).

F14H12.2

Caenorhabditis elegans

Is affected by several genes including daf-2; let-60; and hsf-1 based on RNA-seq and microarray studies. Is affected by seven chemicals including methylmercury hydroxide; multi-walled carbon nanotube; and Psoralens based on RNA-seq studies.

fbxa-130

Caenorhabditis elegans

Is affected by several genes including let-60; eat-2; and sir-2.1 based on tiling array; microarray; and RNA-seq studies. Is affected by six chemicals including Rifampin; allantoin; and Sirolimus based on RNA-seq and microarray studies.

linc-2

Caenorhabditis elegans

Enriched in AFD and head mesodermal cell based on RNA-seq studies. Is affected by several genes including cep-1; set-2; and let-418 based on RNA-seq studies. Is affected by Tunicamycin based on RNA-seq studies.

W06G6.9

Caenorhabditis elegans

Is affected by several genes including let-60; pmk-1; and nhr-49 based on microarray and RNA-seq studies. Is affected by four chemicals including silicon dioxide nanoparticle; Colistin; and adsorbable organic bromine compound based on microarray studies.

C33B4.5

Caenorhabditis elegans

Enriched in neurons and sensory neurons based on RNA-seq studies. Is affected by several genes including drh-3; let-418; and emb-4 based on RNA-seq and microarray studies. Is affected by methylmercuric chloride based on microarray studies.

T12A2.6

Caenorhabditis elegans

Enriched in RID based on RNA-seq studies. Is affected by several genes including let-60; hpl-2; and drh-3 based on tiling array; RNA-seq; and microarray studies. Is affected by Atrazine and Chlorpyrifos based on microarray studies.

sli-1

Caenorhabditis elegans

Predicted to enable SH3 domain binding activity; receptor tyrosine kinase binding activity; and ubiquitin protein ligase activity. Involved in negative regulation of vulval development. Predicted to be located in membrane raft and plasma membrane. Expressed in several structures, including anal depressor muscle; body wall musculature; distal tip cell; head; and intestine. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung squamous cell carcinoma. Is an ortholog of human CBL (Cbl proto-oncogene); CBLB (Cbl proto-oncogene B); and CBLC (Cbl proto-oncogene C).

epic-3

Caenorhabditis elegans

Is affected by several genes including let-60; eat-2; and clk-1 based on tiling array; microarray; and RNA-seq studies. Is affected by multi-walled carbon nanotube; silicon dioxide nanoparticle; and nitroguanidine based on RNA-seq and microarray studies.

C46C2.4

Caenorhabditis elegans

Enriched in AVK based on RNA-seq studies. Is affected by several genes including let-60; eat-2; and sek-1 based on RNA-seq and microarray studies. Is affected by four chemicals including Psoralens; allantoin; and Sirolimus based on RNA-seq studies.

K08B12.4

Caenorhabditis elegans

Enriched in head mesodermal cell based on RNA-seq studies. Is affected by several genes including daf-16; let-418; and chd-3 based on RNA-seq studies. Is affected by four chemicals including allantoin; Sirolimus; and Rifampin based on RNA-seq studies.

Y67D8C.12

Caenorhabditis elegans

Enriched in head mesodermal cell; neurons; and sensory neurons based on RNA-seq studies. Is affected by several genes including cep-1; let-418; and dlc-1 based on RNA-seq studies. Is affected by Oligosaccharides and Colistin based on microarray studies.

F21F8.6

Caenorhabditis elegans

Enriched in intestine based on RNA-seq studies. Is affected by several genes including let-60; elt-2; and dpy-7 based on microarray and RNA-seq studies. Is affected by multi-walled carbon nanotube and Sodium Chloride based on RNA-seq studies.

F44D12.16

Caenorhabditis elegans

Enriched in male based on RNA-seq studies. Is affected by several genes including let-60; sir-2.1; and hpl-2 based on RNA-seq and microarray studies. Is affected by five chemicals including Tamoxifen; resveratrol; and Acrylamide based on RNA-seq and microarray studies.

let-49

Caenorhabditis elegans

Predicted to enable transcription coregulator activity. Involved in embryo development and reproduction. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Is an ortholog of human MED7 (mediator complex subunit 7).

F35E2.7

Caenorhabditis elegans

Enriched in male based on RNA-seq studies. Is affected by several genes including let-60; lin-4; and eat-2 based on RNA-seq and microarray studies. Is affected by seven chemicals including Psoralens; allantoin; and metformin based on RNA-seq and microarray studies.

F42A6.2

Caenorhabditis elegans

Enriched in male based on RNA-seq studies. Is affected by several genes including let-60; daf-12; and rrf-3 based on microarray and RNA-seq studies. Is affected by eight chemicals including Alovudine; Zidovudine; and Psoralens based on RNA-seq and microarray studies.

K02B2.6

Caenorhabditis elegans

Enriched in sensory neurons based on RNA-seq studies. Is affected by several genes including daf-2; let-60; and eat-2 based on microarray and RNA-seq studies. Is affected by five chemicals including Tunicamycin; silicon dioxide nanoparticle; and resveratrol based on microarray studies.

sur-4

Caenorhabditis elegans

let-653

Caenorhabditis elegans

A structural constituent of cuticle. Involved in several processes, including cuticle pattern formation; embryonic ectodermal digestive tract morphogenesis; and regulation of developmental process. Located in apical plasma membrane; extracellular space; and supramolecular fiber. Expressed in excretory duct cell; excretory socket cell; rectal epithelial cell; and vulval cell.

PPA17246

Pristionchus pacificus

Is an ortholog of C. elegans let-92. In C. elegans, let-92 is involved in organelle organization.

C33D3.4

Caenorhabditis elegans

Enriched in ASER based on RNA-seq studies. Is affected by several genes including let-60; rrf-3; and elt-2 based on tiling array; RNA-seq; and microarray studies. Is affected by antimycin and dafa#1 based on RNA-seq and microarray studies.

apc-11

Caenorhabditis elegans

Enables ubiquitin-protein transferase activity. Involved in anaphase-promoting complex-dependent catabolic process; embryo development; and meiotic chromosome segregation. Predicted to be located in nucleus. Predicted to be part of anaphase-promoting complex. Expressed in germ line. Is an ortholog of human ANAPC11 (anaphase promoting complex subunit 11).

let-2

Caenorhabditis elegans

An extracellular matrix structural constituent conferring tensile strength. Involved in several processes, including embryo development; gonad morphogenesis; and regulation of distal tip cell migration. Located in basement membrane. Part of collagen type IV trimer. Expressed in several structures, including coelomocyte; egg-laying apparatus; rectal muscle; spermatheca; and tail. Human ortholog(s) of this gene implicated in several diseases, including X-linked Alport syndrome; X-linked deafness 6; and artery disease (multiple). Is an ortholog of human COL4A1 (collagen type IV alpha 1 chain); COL4A5 (collagen type IV alpha 5 chain); and COL4A6 (collagen type IV alpha 6 chain).

let-23

Caenorhabditis elegans

Enables epidermal growth factor receptor activity. Involved in several processes, including determination of adult lifespan; positive regulation of vulval development; and reproductive structure development. Located in cell-cell junction and plasma membrane. Expressed in several structures, including apoptotic cell; egg-laying apparatus; excretory duct cell; head; and vulval precursor cell. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); hypertension (multiple); and reproductive organ cancer (multiple). Is an ortholog of human EGFR (epidermal growth factor receptor) and ERBB4 (erb-b2 receptor tyrosine kinase 4).

F52E1.12

Caenorhabditis elegans

Enriched in muscle cell based on microarray studies. Is affected by several genes including daf-16; let-60; and daf-12 based on RNA-seq and microarray studies. Is affected by four chemicals including aldicarb; Sodium Chloride; and resveratrol based on microarray and RNA-seq studies.

C54F6.17

Caenorhabditis elegans

Enriched in intestine based on RNA-seq studies. Is affected by several genes including daf-2; let-60; and eat-2 based on RNA-seq and microarray studies. Is affected by nine chemicals including Sodium Chloride; Psoralens; and allantoin based on RNA-seq and microarray studies.

F19G12.2

Caenorhabditis elegans

Enriched in ABalpppappp; ABpraaaappp; AVK; and neurons based on RNA-seq and single-cell RNA-seq studies. Is affected by several genes including daf-16; let-60; and sir-2.1 based on RNA-seq and microarray studies. Is affected by Microcystin-LR based on microarray studies.

ZK930.7

Caenorhabditis elegans

Enriched in male based on RNA-seq studies. Is affected by several genes including let-60; eat-2; and sir-2.1 based on microarray and RNA-seq studies. Is affected by nine chemicals including methylmercuric chloride; Rifampin; and antimycin based on microarray and RNA-seq studies.