daf-12 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables nuclear receptor activity; sequence-specific DNA binding activity; and steroid hormone binding activity. Involved in several processes, including determination of adult lifespan; heat acclimation; and positive regulation of dauer larval development. Located in nucleus. Expressed in several structures, including gonad; neurons; pharyngeal muscle cell; somatic gonad precursor; and vulva. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); autosomal recessive limb-girdle muscular dystrophy type 2B; carcinoma (multiple); and lung disease (multiple). Is an ortholog of human VDR (vitamin D receptor).
Bcar3 [Search on AGR]
Homo sapiens Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
mig-23 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables ADP phosphatase activity; GDP phosphatase activity; and UDP phosphatase activity. Involved in several processes, including gonad morphogenesis; positive regulation of protein glycosylation; and ribonucleoside diphosphate catabolic process. Located in cytoplasm. Expressed in head and tail. Is an ortholog of human ENTPD4 (ectonucleoside triphosphate diphosphohydrolase 4) and ENTPD7 (ectonucleoside triphosphate diphosphohydrolase 7).
mig-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable serine-type endopeptidase inhibitor activity. Involved in several processes, including anatomical structure morphogenesis; distal tip cell migration; and nematode larval development. Located in basement membrane. Expressed in several structures, including CAN; GLR; basal lamina; enteric muscle; and somatic gonad precursor. Is an ortholog of human PAPLN (papilin, proteoglycan like sulfated glycoprotein).
mig-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables metallopeptidase activity. Involved in several processes, including gonad morphogenesis; protein processing; and regulation of distal tip cell migration. Located in basement membrane and extracellular space. Expressed in several structures, including body wall musculature; gonad; head; intestine; and ventral nerve cord.
mig-13 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in positive regulation of cell migration. Located in axon; neuronal cell body; and plasma membrane. Expressed in several structures, including QR.a; QR.p; QR.pa; body ganglion; and somatic neurons.
mig-14 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable Wnt-protein binding activity. Involved in several processes, including Wnt signaling pathway; embryonic morphogenesis; and left/right axis specification. Located in basolateral plasma membrane and cytoplasmic vesicle. Expressed in several structures, including CAN; anal region; intestinal muscle; tail hypodermis; and ventral nerve cord. Is an ortholog of human WLS (Wnt ligand secretion mediator).
mig-32 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables histone ubiquitin ligase activity. Involved in several processes, including negative regulation of vulval development; nematode male tail tip morphogenesis; and regulation of axon extension involved in axon guidance. Located in nucleolus. Expressed in several structures, including germ line and ventral ganglion. Is an ortholog of human PCGF3 (polycomb group ring finger 3).
mig-15 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable protein serine/threonine kinase activity. Involved in several processes, including dorsal/ventral axon guidance; nematode larval development; and regulation of GABAergic synaptic transmission. Predicted to be located in cytoplasm. Expressed in several structures, including QL; QR; body wall musculature; pharynx; and somatic nervous system. Used to study epilepsy. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive intellectual developmental disorder 54; gastrointestinal system cancer (multiple); and hepatitis B. Is an ortholog of human MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4); MINK1 (misshapen like kinase 1); and TNIK (TRAF2 and NCK interacting kinase).
mig-10 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables SH3 domain binding activity. Involved in several processes, including cell migration; cell projection organization; and egg-laying behavior. Located in neuronal cell body membrane; plasma membrane bounded cell projection; and presynaptic cytosol. Part of filamentous actin. Expressed in hermaphrodite gonad; neurons; and tail. Is an ortholog of human RAPH1 (Ras association (RalGDS/AF-6) and pleckstrin homology domains 1).
mig-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables GTPase activity and protein kinase binding activity. Involved in several processes, including actin cytoskeleton organization; axon guidance; and cell migration. Located in cytoplasm; cytoplasmic side of plasma membrane; and neuron projection. Expressed in several structures, including CAN; HSN; distal tip cell; touch receptor neurons; and vulval cell. Used to study epilepsy. Is an ortholog of human RHOG (ras homolog family member G).
mig-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable frizzled binding activity. Involved in several processes, including cell differentiation; inductive cell migration; and non-canonical Wnt signaling pathway. Located in cell cortex. Expressed in several structures, including distal tip cell; linker cell; nerve ring; posterior lateral left ganglion; and somatic gonad precursor. Human ortholog(s) of this gene implicated in DiGeorge syndrome; Robinow syndrome (multiple); and lung cancer. Is an ortholog of human DVL1 (dishevelled segment polarity protein 1); DVL2 (dishevelled segment polarity protein 2); and DVL3 (dishevelled segment polarity protein 3).
mig-21 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable signaling receptor activity. Involved in several processes, including cell migration; determination of left/right asymmetry in nervous system; and regulation of canonical Wnt signaling pathway. Predicted to be located in plasma membrane. Expressed in QL; QR; and body wall musculature.
mlt-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables peroxidase activity. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle; nematode larval development; and post-embryonic body morphogenesis. Predicted to be located in extracellular space. Expressed in anterior hypodermis and hypodermal cell.
dhcr-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 7-dehydrocholesterol reductase activity and sterol delta7 reductase activity. Predicted to be involved in brassinosteroid biosynthetic process and cholesterol biosynthetic process. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in several diseases, including Greenberg dysplasia; Pelger-Huet anomaly; and Smith-Lemli-Opitz syndrome. Is an ortholog of human DHCR7 (7-dehydrocholesterol reductase).
ttx-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable inositol monophosphate 1-phosphatase activity and metal ion binding activity. Involved in chemotaxis; protein localization to synapse; and thermotaxis. Located in cytoplasm. Expressed in several structures, including coelomocyte; gonad; intestine; neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 59; bipolar disorder; and schizophrenia. Is an ortholog of human IMPA1 (inositol monophosphatase 1) and IMPA2 (inositol monophosphatase 2).
fkb-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome kyphoscoliotic type 2. Is an ortholog of human FKBP14 (FKBP prolyl isomerase 14) and FKBP7 (FKBP prolyl isomerase 7).
tomm-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in mitochondrion organization. Predicted to be located in mitochondrial outer membrane. Predicted to be part of mitochondrial outer membrane translocase complex. Expressed in intestine and pharynx. Is an ortholog of human TOMM7 (translocase of outer mitochondrial membrane 7).
osm-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable Notch binding activity. Involved in regulation of gene expression and response to osmotic stress. Predicted to be located in extracellular space. Expressed in hypodermis.
ins-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable hormone activity. Involved in olfactory learning. Predicted to be located in extracellular region and membrane. Expressed in several structures, including distal tip cell; egg-laying apparatus; head muscle; neurons; and somatic nervous system.
mig-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable Wnt receptor activity and Wnt-protein binding activity. Involved in several processes, including mitochondrial unfolded protein response; neuron migration; and positive regulation of axon guidance. Predicted to be located in plasma membrane. Expressed in anal depressor muscle; head muscle; and neurons. Human ortholog(s) of this gene implicated in exudative vitreoretinopathy 1 and prostate carcinoma in situ. Is an ortholog of human FZD4 (frizzled class receptor 4).
cogc-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in gonad morphogenesis and regulation of cell migration. Located in Golgi apparatus and endoplasmic reticulum. Expressed in intestine; pharynx; seam cell; and vulva. Is an ortholog of human COG3 (component of oligomeric golgi complex 3).
unc-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables gap junction channel activity. Involved in several processes, including regulation of multicellular organismal process; reproductive behavior; and response to anesthetic. Located in gap junction and neuron projection membrane. Expressed in several structures, including OL socket cell; intestine; muscle cell; neurons; and pharyngeal gland cell.
ser-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger and chemical synaptic transmission. Located in membrane. Expressed in pharyngeal neurons and vulval muscle. Human ortholog(s) of this gene implicated in alcohol use disorder. Is an ortholog of human HTR7 (5-hydroxytryptamine receptor 7).
sur-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in several processes, including cellular response to zinc ion; muscle cell cellular homeostasis; and positive regulation of Ras protein signal transduction. Located in endoplasmic reticulum membrane. Expressed in several structures, including hypodermis; muscle cell; pharynx; tail; and vulva.
elt-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in endodermal cell fate determination. Located in nucleus. Expressed in E lineage cell.
ncx-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable calcium:sodium antiporter activity. Predicted to be involved in intracellular calcium ion homeostasis and monoatomic cation transport. Predicted to be located in membrane. Expressed in ADLL; ADLR; amphid neurons; and tail neurons. Is an ortholog of human SLC8B1 (solute carrier family 8 member B1).
pbs-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in proteasomal protein catabolic process. Predicted to be located in nucleus. Predicted to be part of proteasome core complex, beta-subunit complex. Is an ortholog of human PSMB4 (proteasome 20S subunit beta 4).
rab-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables GTPase activity. Involved in several processes, including oocyte growth; positive regulation of early endosome to late endosome transport; and vesicle-mediated transport. Located in late endosome membrane; lysosome; and phagocytic vesicle membrane. Expressed in several structures, including oocyte. Used to study obesity. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2B. Is an ortholog of human RAB7A (RAB7A, member RAS oncogene family).
gly-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation. Predicted to be located in Golgi apparatus. Is an ortholog of human GALNT7 (polypeptide N-acetylgalactosaminyltransferase 7).
let-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables mRNA 3'-UTR binding activity. Involved in several processes, including negative regulation of Ras protein signal transduction; negative regulation of gene expression; and regulation of development, heterochronic. Part of RISC complex. Expressed in several structures, including gonad; hypodermis; somatic nervous system; touch receptor neurons; and vulval precursor cell. Used to study cancer.
tag-72 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA binding activity and mRNA (guanine-N7-)-methyltransferase activity. Predicted to be involved in 7-methylguanosine mRNA capping. Predicted to be located in nucleus. Predicted to be part of mRNA cap binding activity complex. Is an ortholog of human RNMT (RNA guanine-7 methyltransferase).
lin-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables protein-macromolecule adaptor activity and signaling receptor binding activity. Involved in several processes, including egg-laying behavior; positive regulation of vulval development; and protein localization to basolateral plasma membrane. Located in cell-cell junction. Expressed in gonad; head; somatic gonad precursor; somatic nervous system; and vulval precursor cell. Is an ortholog of human LIN7A (
lin-7 homolog A, crumbs cell polarity complex component); LIN7B (
lin-7 homolog B, crumbs cell polarity complex component); and LIN7C (
lin-7 homolog C, crumbs cell polarity complex component).
lpd-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA binding activity. Involved in lipid storage. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of PeBoW complex. Is an ortholog of human PES1 (pescadillo ribosomal biogenesis factor 1).
F18H3.1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Expressed in head neurons; pharyngeal neurons; and sensory neurons. Is predicted to encode a protein with the following domains: Concanavalin A-like lectin/glucanase domain superfamily; SPRY domain; B30.2/SPRY domain superfamily; and SPRY domain-containing protein 7. Is an ortholog of human SPRYD7 (SPRY domain containing 7).
gcy-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable adenylate cyclase activity; guanylate cyclase activity; and peptide receptor activity. Involved in chemosensory behavior; chemotaxis; and response to magnesium ion. Located in cilium. Expressed in ASEL.
cct-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be located in cytoplasm. Predicted to be part of chaperonin-containing T-complex. Expressed in anchor cell; head; non-striated muscle; and tail. Is an ortholog of human CCT7 (chaperonin containing TCP1 subunit 7).
cogc-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in several processes, including gonad morphogenesis; regulation of cell migration; and vulval development. Predicted to be located in Golgi apparatus. Predicted to be part of Golgi transport complex. Expressed in germ line. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIg. Is an ortholog of human COG1 (component of oligomeric golgi complex 1).
ubc-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein polyubiquitination. Is an ortholog of human UBE2G1 (ubiquitin conjugating enzyme E2 G1).
bcl-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in Wnt signaling pathway; apoptotic process; and cell differentiation. Predicted to be located in nucleus. Expressed in distal tip cell; germ cell; and gonadal sheath cell. Is an ortholog of human BCL7A (BAF chromatin remodeling complex subunit BCL7A).
sig-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II complex binding activity. Involved in nematode larval development; positive regulation of developmental process; and transcription elongation-coupled chromatin remodeling. Located in nucleoplasm. Part of euchromatin. Expressed in several structures, including intestine. Is an ortholog of human PPIL4 (peptidylprolyl isomerase like 4).
mboa-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables O-acyltransferase activity. Involved in egg-laying behavior; nematode larval development; and phosphatidylinositol biosynthetic process. Located in intracellular membrane-bounded organelle. Expressed in several structures, including hermaphrodite distal tip cell; intestine; pharyngeal muscle cell; spermatheca; and vulva. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 57. Is an ortholog of human MBOAT7 (membrane bound O-acyltransferase domain containing 7).
sand-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in several processes, including nematode larval development; regulation of cellular localization; and vesicle-mediated transport. Located in early endosome and membrane. Is an ortholog of human MON1B (MON1 homolog B, secretory trafficking associated).
atg-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable Atg12 activating enzyme activity and Atg8 activating enzyme activity. Involved in several processes, including dauer larval development; determination of adult lifespan; and positive regulation of autophagosome assembly. Predicted to be located in phagophore assembly site. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 31. Is an ortholog of human ATG7 (autophagy related 7).
taf-7.1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable histone acetyltransferase regulator activity and transcription coactivator activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIID complex. Is an ortholog of human TAF7 (TATA-box binding protein associated factor 7) and TAF7L (TATA-box binding protein associated factor 7 like).
fkh-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in several structures, including intestine; neurons; pharynx; reproductive system; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); communication disorder (multiple); and tuberculosis (multiple). Is an ortholog of human FOXP2 (forkhead box P2).
nsy-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables sequence-specific DNA binding activity. Involved in determination of left/right asymmetry in nervous system and negative regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in amphid sheath cell; intestine; and neurons.
lbp-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable fatty acid binding activity. Predicted to be involved in fatty acid transport. Predicted to be located in cytosol and nucleus. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Charcot-Marie-Tooth disease type 1G; Down syndrome; and artery disease (multiple). Is an ortholog of several human genes including FABP3 (fatty acid binding protein 3); FABP7 (fatty acid binding protein 7); and PMP2 (peripheral myelin protein 2).
ced-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATP binding activity; ATPase-coupled transmembrane transporter activity; and lipid transporter activity. Involved in several processes, including engulfment of apoptotic cell; left/right axis specification; and phospholipid efflux. Located in plasma membrane. Expressed in Z2; Z3; germ line; neuronal sheath cell; and pharyngeal-intestinal valve.
vha-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATPase binding activity. Predicted to be involved in vacuolar acidification. Predicted to be located in plasma membrane. Predicted to be part of vacuolar proton-transporting V-type ATPase complex. Expressed in hypodermis; spermatheca; and uterus. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive cutis laxa type IIA; autosomal recessive osteopetrosis 1; and developmental and epileptic encephalopathy 104. Is an ortholog of several human genes including ATP6V0A1 (ATPase H+ transporting V0 subunit
a1); ATP6V0A2 (ATPase H+ transporting V0 subunit
a2); and TCIRG1 (T cell immune regulator 1, ATPase H+ transporting V0 subunit
a3).
taf-7.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIID complex. Is an ortholog of human TAF7 (TATA-box binding protein associated factor 7) and TAF7L (TATA-box binding protein associated factor 7 like).
sra-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable olfactory receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception. Predicted to be located in membrane. Expressed in head and tail.
Bma-mig-17 [Browse genome (BioProject PRJNA10729)] [Search on AGR]
Brugia malayi Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Is an ortholog of C. elegans
mig-17. In C. elegans,
mig-17 is involved in several processes, including gonad morphogenesis; protein processing; and regulation of distal tip cell migration.
Cbr-mig-17 [Browse genome (BioProject PRJNA10731)] [Search on AGR]
Caenorhabditis briggsae Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Is an ortholog of C. elegans
mig-17. In C. elegans,
mig-17 is involved in several processes, including gonad morphogenesis; protein processing; and regulation of distal tip cell migration.
Ppa-mig-17 [Browse genome (BioProject PRJNA12644)] [Search on AGR]
Pristionchus pacificus Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Is an ortholog of C. elegans
mig-17. In C. elegans,
mig-17 is involved in several processes, including gonad morphogenesis; protein processing; and regulation of distal tip cell migration.
lim-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including gonad morphogenesis; head morphogenesis; and pharynx development. Located in nucleus. Expressed in several structures, including body wall musculature; head neurons; lumbar neurons; pharyngeal neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including atrial fibrillation; diabetes mellitus (multiple); and heart septal defect (multiple). Is an ortholog of human ISL1 (ISL LIM homeobox 1) and ISL2 (ISL LIM homeobox 2).
tbx-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell fate specification and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex.
Ovo-mig-17 [Browse genome (BioProject PRJEB513)] [Search on AGR]
Onchocerca volvulus Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Is an ortholog of C. elegans
mig-17. In C. elegans,
mig-17 is involved in several processes, including gonad morphogenesis; protein processing; and regulation of distal tip cell migration.
Cbn-mig-17 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Is an ortholog of C. elegans
mig-17. In C. elegans,
mig-17 is involved in several processes, including gonad morphogenesis; protein processing; and regulation of distal tip cell migration.
Cjp-mig-17 [Browse genome (BioProject PRJNA12591)] [Search on AGR]
Caenorhabditis japonica Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Is an ortholog of C. elegans
mig-17. In C. elegans,
mig-17 is involved in several processes, including gonad morphogenesis; protein processing; and regulation of distal tip cell migration.
Cre-mig-17 [Browse genome (BioProject PRJNA577507)] [Search on AGR]
Caenorhabditis remanei Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Is an ortholog of C. elegans
mig-17. In C. elegans,
mig-17 is involved in several processes, including gonad morphogenesis; protein processing; and regulation of distal tip cell migration.
sax-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables ankyrin binding activity. Involved in several processes, including cell development; establishment of mitotic spindle orientation; and regulation of cell morphogenesis. Located in several cellular components, including axolemma; lateral plasma membrane; and somatodendritic compartment. Expressed in several structures, including gonad; neurons; pharynx; somatic nervous system; and vulval cell. Used to study MASA syndrome. Human ortholog(s) of this gene implicated in schizophrenia. Is an ortholog of human NFASC (neurofascin) and NRCAM (neuronal cell adhesion molecule).
pgp-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in stress response to cadmium ion. Predicted to be located in membrane. Expressed in tail. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); and intrahepatic cholestasis (multiple). Is an ortholog of several human genes including ABCB1 (ATP binding cassette subfamily B member 1); ABCB11 (ATP binding cassette subfamily B member 11); and ABCB4 (ATP binding cassette subfamily B member 4).
Cbr-mig-15 [Browse genome (BioProject PRJNA10731)] [Search on AGR]
Caenorhabditis briggsae Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans
mig-15. In C. elegans,
mig-15 is involved in several processes, including dorsal/ventral axon guidance; nematode larval development; and regulation of GABAergic synaptic transmission.
mct-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 7 and lymphangioleiomyomatosis. Is an ortholog of several human genes including SLC16A1 (solute carrier family 16 member 1); SLC16A7 (solute carrier family 16 member 7); and SLC16A8 (solute carrier family 16 member 8).
Bma-mig-5 [Browse genome (BioProject PRJNA10729)] [Search on AGR]
Brugia malayi Predicted to be involved in Wnt signaling pathway and intracellular signal transduction. Is an ortholog of C. elegans
mig-5. In C. elegans,
mig-5 is involved in several processes, including cell differentiation; inductive cell migration; and non-canonical Wnt signaling pathway.
Cbn-mig-15 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans
mig-15. In C. elegans,
mig-15 is involved in several processes, including dorsal/ventral axon guidance; nematode larval development; and regulation of GABAergic synaptic transmission.
Ovo-mig-15 [Browse genome (BioProject PRJEB513)] [Search on AGR]
Onchocerca volvulus Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans
mig-15. In C. elegans,
mig-15 is involved in several processes, including dorsal/ventral axon guidance; nematode larval development; and regulation of GABAergic synaptic transmission.
nhr-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation; hormone-mediated signaling pathway; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.
mdt-29 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in lateral inhibition; positive regulation of Notch signaling pathway; and regulation of cell fate specification. Predicted to be located in nucleus. Predicted to be part of mediator complex. Expressed in body wall musculature.
cux-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in OLL; body wall muscle cell; germ line; and interneuron based on microarray; tiling array; and RNA-seq studies. Is affected by several genes including
daf-2;
skn-1; and
dpy-10 based on RNA-seq and microarray studies. Is affected by five chemicals including D-glucose; Zidovudine; and paraquat based on RNA-seq and microarray studies. Human AKAP17A enables protein kinase A binding activity. Is an ortholog of human AKAP17A (A-kinase anchoring protein 17A).
pas-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables identical protein binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. Is an ortholog of human PSMA3 (proteasome 20S subunit alpha 3).
Bma-mig-15 [Browse genome (BioProject PRJNA10729)] [Search on AGR]
Brugia malayi Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans
mig-15. In C. elegans,
mig-15 is involved in several processes, including dorsal/ventral axon guidance; nematode larval development; and regulation of GABAergic synaptic transmission.
CBN29790 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Predicted to be involved in Wnt signaling pathway and intracellular signal transduction. Is an ortholog of C. elegans
mig-5. In C. elegans,
mig-5 is involved in several processes, including cell differentiation; inductive cell migration; and non-canonical Wnt signaling pathway.
Cjp-mig-15 [Browse genome (BioProject PRJNA12591)] [Search on AGR]
Caenorhabditis japonica Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans
mig-15. In C. elegans,
mig-15 is involved in several processes, including dorsal/ventral axon guidance; nematode larval development; and regulation of GABAergic synaptic transmission.
SRAE_X000152400 [Browse genome (BioProject PRJEB125)] [Search on AGR]
Strongyloides ratti Predicted to be involved in Wnt signaling pathway and intracellular signal transduction. Is an ortholog of C. elegans
mig-5. In C. elegans,
mig-5 is involved in several processes, including cell differentiation; inductive cell migration; and non-canonical Wnt signaling pathway.
Cbr-mig-5 [Browse genome (BioProject PRJNA10731)] [Search on AGR]
Caenorhabditis briggsae Predicted to be involved in Wnt signaling pathway and intracellular signal transduction. Is an ortholog of C. elegans
mig-5. In C. elegans,
mig-5 is involved in several processes, including cell differentiation; inductive cell migration; and non-canonical Wnt signaling pathway.
Cjp-mig-5 [Browse genome (BioProject PRJNA12591)] [Search on AGR]
Caenorhabditis japonica Predicted to be involved in Wnt signaling pathway and intracellular signal transduction. Is an ortholog of C. elegans
mig-5. In C. elegans,
mig-5 is involved in several processes, including cell differentiation; inductive cell migration; and non-canonical Wnt signaling pathway.
Cre-mig-15 [Browse genome (BioProject PRJNA577507)] [Search on AGR]
Caenorhabditis remanei Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans
mig-15. In C. elegans,
mig-15 is involved in several processes, including dorsal/ventral axon guidance; nematode larval development; and regulation of GABAergic synaptic transmission.
Cre-mig-5 [Browse genome (BioProject PRJNA577507)] [Search on AGR]
Caenorhabditis remanei Predicted to be involved in Wnt signaling pathway and intracellular signal transduction. Is an ortholog of C. elegans
mig-5. In C. elegans,
mig-5 is involved in several processes, including cell differentiation; inductive cell migration; and non-canonical Wnt signaling pathway.
Ovo-mig-5 [Browse genome (BioProject PRJEB513)] [Search on AGR]
Onchocerca volvulus Predicted to be involved in Wnt signaling pathway and intracellular signal transduction. Is an ortholog of C. elegans
mig-5. In C. elegans,
mig-5 is involved in several processes, including cell differentiation; inductive cell migration; and non-canonical Wnt signaling pathway.
Ppa-mig-15 [Browse genome (BioProject PRJNA12644)] [Search on AGR]
Pristionchus pacificus Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans
mig-15. In C. elegans,
mig-15 is involved in several processes, including dorsal/ventral axon guidance; nematode larval development; and regulation of GABAergic synaptic transmission.
Ppa-mig-5 [Browse genome (BioProject PRJNA12644)] [Search on AGR]
Pristionchus pacificus Predicted to be involved in Wnt signaling pathway and intracellular signal transduction. Is an ortholog of C. elegans
mig-5. In C. elegans,
mig-5 is involved in several processes, including cell differentiation; inductive cell migration; and non-canonical Wnt signaling pathway.
Cbn-mig-5 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Predicted to be involved in Wnt signaling pathway and intracellular signal transduction. Is an ortholog of C. elegans
mig-5. In C. elegans,
mig-5 is involved in several processes, including cell differentiation; inductive cell migration; and non-canonical Wnt signaling pathway.
Bma-mig-14 [Browse genome (BioProject PRJNA10729)] [Search on AGR]
Brugia malayi Predicted to enable Wnt-protein binding activity. Predicted to be involved in Wnt signaling pathway. Is an ortholog of C. elegans
mig-14. In C. elegans,
mig-14 is involved in several processes, including Wnt signaling pathway; embryonic morphogenesis; and left/right axis specification.
Cjp-mig-14 [Browse genome (BioProject PRJNA12591)] [Search on AGR]
Caenorhabditis japonica Predicted to enable Wnt-protein binding activity. Predicted to be involved in Wnt signaling pathway. Is an ortholog of C. elegans
mig-14. In C. elegans,
mig-14 is involved in several processes, including Wnt signaling pathway; embryonic morphogenesis; and left/right axis specification.
Ppa-mig-14 [Browse genome (BioProject PRJNA12644)] [Search on AGR]
Pristionchus pacificus Predicted to enable Wnt-protein binding activity. Predicted to be involved in Wnt signaling pathway. Is an ortholog of C. elegans
mig-14. In C. elegans,
mig-14 is involved in several processes, including Wnt signaling pathway; embryonic morphogenesis; and left/right axis specification.
fut-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity. Involved in fucosylation. Predicted to be located in Golgi cisterna membrane. Is an ortholog of human FUT7 (fucosyltransferase 7).
Cbn-mig-32.2 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Predicted to enable metal ion binding activity. Is an ortholog of C. elegans
mig-32. In C. elegans,
mig-32 is involved in several processes, including negative regulation of vulval development; nematode male tail tip morphogenesis; and regulation of axon extension involved in axon guidance.
Cbr-mig-14 [Browse genome (BioProject PRJNA10731)] [Search on AGR]
Caenorhabditis briggsae Predicted to enable Wnt-protein binding activity. Predicted to be involved in Wnt signaling pathway. Is an ortholog of C. elegans
mig-14. In C. elegans,
mig-14 is involved in several processes, including Wnt signaling pathway; embryonic morphogenesis; and left/right axis specification.
Ppa-mig-32 [Browse genome (BioProject PRJNA12644)] [Search on AGR]
Pristionchus pacificus Predicted to enable metal ion binding activity. Is an ortholog of C. elegans
mig-32. In C. elegans,
mig-32 is involved in several processes, including negative regulation of vulval development; nematode male tail tip morphogenesis; and regulation of axon extension involved in axon guidance.
Cre-mig-14 [Browse genome (BioProject PRJNA577507)] [Search on AGR]
Caenorhabditis remanei Predicted to enable Wnt-protein binding activity. Predicted to be involved in Wnt signaling pathway. Is an ortholog of C. elegans
mig-14. In C. elegans,
mig-14 is involved in several processes, including Wnt signaling pathway; embryonic morphogenesis; and left/right axis specification.
Ovo-mig-14 [Browse genome (BioProject PRJEB513)] [Search on AGR]
Onchocerca volvulus Predicted to enable Wnt-protein binding activity. Predicted to be involved in Wnt signaling pathway. Is an ortholog of C. elegans
mig-14. In C. elegans,
mig-14 is involved in several processes, including Wnt signaling pathway; embryonic morphogenesis; and left/right axis specification.
sel-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables identical protein binding activity and sequence-specific DNA binding activity. Involved in several processes, including lateral inhibition; negative regulation of transcription by RNA polymerase II; and positive regulation of Notch signaling pathway. Located in nucleus. Expressed in body wall musculature; pharyngeal muscle cell; and seam cell.
Bma-mig-32 [Browse genome (BioProject PRJNA10729)] [Search on AGR]
Brugia malayi Predicted to enable metal ion binding activity. Is an ortholog of C. elegans
mig-32. In C. elegans,
mig-32 is involved in several processes, including negative regulation of vulval development; nematode male tail tip morphogenesis; and regulation of axon extension involved in axon guidance.
Cbn-mig-14 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Predicted to enable Wnt-protein binding activity. Predicted to be involved in Wnt signaling pathway. Is an ortholog of C. elegans
mig-14. In C. elegans,
mig-14 is involved in several processes, including Wnt signaling pathway; embryonic morphogenesis; and left/right axis specification.
Cbn-mig-32.1 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Predicted to enable metal ion binding activity. Is an ortholog of C. elegans
mig-32. In C. elegans,
mig-32 is involved in several processes, including negative regulation of vulval development; nematode male tail tip morphogenesis; and regulation of axon extension involved in axon guidance.
CBN32250 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Predicted to enable Wnt-protein binding activity. Predicted to be involved in Wnt signaling pathway. Is an ortholog of C. elegans
mig-14. In C. elegans,
mig-14 is involved in several processes, including Wnt signaling pathway; embryonic morphogenesis; and left/right axis specification.
SRAE_2000284800 [Browse genome (BioProject PRJEB125)] [Search on AGR]
Strongyloides ratti Predicted to enable Wnt-protein binding activity. Predicted to be involved in Wnt signaling pathway. Is an ortholog of C. elegans
mig-14. In C. elegans,
mig-14 is involved in several processes, including Wnt signaling pathway; embryonic morphogenesis; and left/right axis specification.
swan-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables LIM domain binding activity and small GTPase binding activity. Involved in several processes, including regulation of cellular component organization; response to heat; and response to osmotic stress. Located in cytoplasm. Expressed in several structures, including neuroblasts and neurons. Is an ortholog of human DCAF7 (DDB1 and CUL4 associated factor 7).
mct-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Predicted to be located in membrane. Expressed in tail. Human ortholog(s) of this gene implicated in cataract 47; familial hyperinsulinemic hypoglycemia 7; and lymphangioleiomyomatosis. Is an ortholog of several human genes including SLC16A1 (solute carrier family 16 member 1); SLC16A6 (solute carrier family 16 member 6); and SLC16A7 (solute carrier family 16 member 7).
rac-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables GTP binding activity and GTPase activity. Involved in actin filament organization; axon guidance; and neuron migration. Located in axon and plasma membrane. Expressed in nerve ring and neurons. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant intellectual developmental disorder 48; colon adenoma; and gastrointestinal system cancer (multiple). Is an ortholog of human RAC1 (Rac family small GTPase 1).
alkb-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable dioxygenase activity. Predicted to be involved in fatty acid metabolic process. Predicted to be located in mitochondrial matrix. Is an ortholog of human ALKBH7 (alkB homolog 7).
Cbn-mig-6 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in extracellular matrix organization. Is an ortholog of C. elegans
mig-6. In C. elegans,
mig-6 is involved in several processes, including anatomical structure morphogenesis; distal tip cell migration; and nematode larval development.
OVOC6317 [Browse genome (BioProject PRJEB513)] [Search on AGR]
Onchocerca volvulus Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in extracellular matrix organization. Is an ortholog of C. elegans
mig-6. In C. elegans,
mig-6 is involved in several processes, including anatomical structure morphogenesis; distal tip cell migration; and nematode larval development.
SRAE_2000506400 [Browse genome (BioProject PRJEB125)] [Search on AGR]
Strongyloides ratti Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in extracellular matrix organization. Is an ortholog of C. elegans
mig-6. In C. elegans,
mig-6 is involved in several processes, including anatomical structure morphogenesis; distal tip cell migration; and nematode larval development.
Bma-mig-2 [Browse genome (BioProject PRJNA10729)] [Search on AGR]
Brugia malayi Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in small GTPase mediated signal transduction. Is an ortholog of C. elegans
mig-2. In C. elegans,
mig-2 is involved in several processes, including actin cytoskeleton organization; axon guidance; and cell migration.
Cjp-mig-1 [Browse genome (BioProject PRJNA12591)] [Search on AGR]
Caenorhabditis japonica Predicted to be involved in cell surface receptor signaling pathway. Predicted to be located in membrane. Is an ortholog of C. elegans
mig-1. In C. elegans,
mig-1 is involved in several processes, including mitochondrial unfolded protein response; neuron migration; and positive regulation of axon guidance.
Ovo-mig-1 [Browse genome (BioProject PRJEB513)] [Search on AGR]
Onchocerca volvulus Predicted to be involved in cell surface receptor signaling pathway. Predicted to be located in membrane. Is an ortholog of C. elegans
mig-1. In C. elegans,
mig-1 is involved in several processes, including mitochondrial unfolded protein response; neuron migration; and positive regulation of axon guidance.
exc-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables single-stranded RNA binding activity. Involved in several processes, including epithelial cell development; regulation of alternative mRNA splicing, via spliceosome; and regulation of neuron differentiation. Located in nuclear speck. Expressed in several structures, including excretory cell; neurons; somatic nervous system; tail; and vulva. Is an ortholog of human ELAVL4 (ELAV like RNA binding protein 4).
spg-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable metalloendopeptidase activity. Involved in several processes, including mitochondrial protein processing; positive regulation of nematode male tail tip morphogenesis; and regulation of gene expression. Predicted to be located in mitochondrion. Predicted to be part of m-AAA complex. Expressed in germ line. Human ortholog(s) of this gene implicated in optic atrophy 12; spastic ataxia 5; and spinocerebellar ataxia type 28. Is an ortholog of human AFG3L2 (AFG3 like matrix AAA peptidase subunit 2).
Ppa-mig-1 [Browse genome (BioProject PRJNA12644)] [Search on AGR]
Pristionchus pacificus Predicted to be involved in cell surface receptor signaling pathway. Predicted to be located in membrane. Is an ortholog of C. elegans
mig-1. In C. elegans,
mig-1 is involved in several processes, including mitochondrial unfolded protein response; neuron migration; and positive regulation of axon guidance.
Ppa-mig-6 [Browse genome (BioProject PRJNA12644)] [Search on AGR]
Pristionchus pacificus Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in extracellular matrix organization. Is an ortholog of C. elegans
mig-6. In C. elegans,
mig-6 is involved in several processes, including anatomical structure morphogenesis; distal tip cell migration; and nematode larval development.
SRAE_2000167000 [Browse genome (BioProject PRJEB125)] [Search on AGR]
Strongyloides ratti Predicted to be involved in cell surface receptor signaling pathway. Predicted to be located in membrane. Is an ortholog of C. elegans
mig-1. In C. elegans,
mig-1 is involved in several processes, including mitochondrial unfolded protein response; neuron migration; and positive regulation of axon guidance.
tgs-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA trimethylguanosine synthase activity. Predicted to be involved in 7-methylguanosine cap hypermethylation. Predicted to be located in nucleus. Is an ortholog of human TGS1 (trimethylguanosine synthase 1).
Bma-mig-6 [Browse genome (BioProject PRJNA10729)] [Search on AGR]
Brugia malayi Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in extracellular matrix organization. Is an ortholog of C. elegans
mig-6. In C. elegans,
mig-6 is involved in several processes, including anatomical structure morphogenesis; distal tip cell migration; and nematode larval development.
Cbr-mig-6 [Browse genome (BioProject PRJNA10731)] [Search on AGR]
Caenorhabditis briggsae Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in extracellular matrix organization. Is an ortholog of C. elegans
mig-6. In C. elegans,
mig-6 is involved in several processes, including anatomical structure morphogenesis; distal tip cell migration; and nematode larval development.
CJA32996 [Browse genome (BioProject PRJNA12591)] [Search on AGR]
Caenorhabditis japonica Predicted to be involved in cell surface receptor signaling pathway. Predicted to be located in membrane. Is an ortholog of C. elegans
mig-1. In C. elegans,
mig-1 is involved in several processes, including mitochondrial unfolded protein response; neuron migration; and positive regulation of axon guidance.
Cjp-mig-6 [Browse genome (BioProject PRJNA12591)] [Search on AGR]
Caenorhabditis japonica Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in extracellular matrix organization. Is an ortholog of C. elegans
mig-6. In C. elegans,
mig-6 is involved in several processes, including anatomical structure morphogenesis; distal tip cell migration; and nematode larval development.
Cre-mig-6 [Browse genome (BioProject PRJNA577507)] [Search on AGR]
Caenorhabditis remanei Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in extracellular matrix organization. Is an ortholog of C. elegans
mig-6. In C. elegans,
mig-6 is involved in several processes, including anatomical structure morphogenesis; distal tip cell migration; and nematode larval development.
dph-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable diphthine methylesterase activity. Predicted to be involved in protein histidyl modification to diphthamide. Predicted to be located in cytoplasm. Is an ortholog of human DPH7 (diphthamide biosynthesis 7).
C06H2.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable lipid binding activity. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 2. Is an ortholog of human STARD7 (StAR related lipid transfer domain containing 7).
daf-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable cytokine activity and transforming growth factor beta receptor binding activity. Involved in several processes, including cellular response to organic substance; regulation of gene expression; and response to bacterium. Located in extracellular space. Expressed in coelomocyte; head neurons; pharynx; and in male. Human ortholog(s) of this gene implicated in myostatin-related muscle hypertrophy and vertebral hypersegmentation and orofacial anomalies. Is an ortholog of human GDF11 (growth differentiation factor 11).
ints-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in snRNA 3'-end processing. Predicted to be located in nucleus. Predicted to be part of integrator complex. Is an ortholog of human INTS7 (integrator complex subunit 7).
odr-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in negative adaptation of signaling pathway; positive chemotaxis; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in AWAL and AWAR.
acr-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in excitatory postsynaptic potential and monoatomic ion transmembrane transport. Predicted to be located in neuron projection and synapse. Expressed in pharyngeal muscle cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Lewy body dementia; carcinoma (multiple); and inflammatory bowel disease (multiple). Is an ortholog of human CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion) and CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit).
dnj-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable misfolded protein binding activity; protein kinase inhibitor activity; and protein-folding chaperone binding activity. Involved in PERK-mediated unfolded protein response. Predicted to be located in endoplasmic reticulum lumen. Expressed in head. Is an ortholog of human DNAJC3 (DnaJ heat shock protein family (Hsp40) member C3).
Cbr-mig-1 [Browse genome (BioProject PRJNA10731)] [Search on AGR]
Caenorhabditis briggsae Predicted to enable Wnt receptor activity. Predicted to be involved in Wnt signaling pathway. Predicted to be located in membrane. Is an ortholog of C. elegans
mig-1. In C. elegans,
mig-1 is involved in several processes, including mitochondrial unfolded protein response; neuron migration; and positive regulation of axon guidance.
Cre-mig-1 [Browse genome (BioProject PRJNA577507)] [Search on AGR]
Caenorhabditis remanei Predicted to enable Wnt receptor activity. Predicted to be involved in Wnt signaling pathway. Predicted to be located in membrane. Is an ortholog of C. elegans
mig-1. In C. elegans,
mig-1 is involved in several processes, including mitochondrial unfolded protein response; neuron migration; and positive regulation of axon guidance.
rpn-8 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable metallopeptidase activity. Involved in programmed cell death involved in cell development. Predicted to be part of proteasome complex. Is an ortholog of human PSMD7 (proteasome 26S subunit, non-ATPase 7).
Bma-mig-1 [Browse genome (BioProject PRJNA10729)] [Search on AGR]
Brugia malayi Predicted to enable Wnt receptor activity. Predicted to be involved in Wnt signaling pathway. Predicted to be located in membrane. Is an ortholog of C. elegans
mig-1. In C. elegans,
mig-1 is involved in several processes, including mitochondrial unfolded protein response; neuron migration; and positive regulation of axon guidance.
CJA21756 [Browse genome (BioProject PRJNA12591)] [Search on AGR]
Caenorhabditis japonica Is predicted to encode a protein with the following domains: GRB/APBB1IP; PH-like domain superfamily; Pleckstrin homology domain; and PH domain. Is an ortholog of C. elegans
mig-10. In C. elegans,
mig-10 is involved in several processes, including cell migration; cell projection organization; and egg-laying behavior.
SRAE_1000057100 [Browse genome (BioProject PRJEB125)] [Search on AGR]
Strongyloides ratti Predicted to enable GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity; GTP binding activity; and GTPase activity. Predicted to be involved in protein glycosylation. Is an ortholog of C. elegans
mig-2. In C. elegans,
mig-2 is involved in several processes, including actin cytoskeleton organization; axon guidance; and cell migration.
ntp-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables pyrophosphatase activity. Involved in ribonucleotide metabolic process. Located in Golgi apparatus and perinuclear region of cytoplasm. Is an ortholog of human ENTPD4 (ectonucleoside triphosphate diphosphohydrolase 4) and ENTPD7 (ectonucleoside triphosphate diphosphohydrolase 7).
CBN28769 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Predicted to enable Wnt receptor activity. Predicted to be involved in Wnt signaling pathway. Predicted to be located in membrane. Is an ortholog of C. elegans
mig-1. In C. elegans,
mig-1 is involved in several processes, including mitochondrial unfolded protein response; neuron migration; and positive regulation of axon guidance.
Cbn-mig-1 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Predicted to enable Wnt receptor activity. Predicted to be involved in Wnt signaling pathway. Predicted to be located in membrane. Is an ortholog of C. elegans
mig-1. In C. elegans,
mig-1 is involved in several processes, including mitochondrial unfolded protein response; neuron migration; and positive regulation of axon guidance.
atf-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and mitogen-activated protein kinase binding activity. Involved in several processes, including defense response to bacterium; regulation of innate immune response; and regulation of transcription by RNA polymerase II. Acts upstream of or within serotonin biosynthetic process. Located in nucleus. Part of chromatin. Expressed in body wall musculature; hypodermis; intestine; neurons; and rectal epithelial cell. Human ortholog(s) of this gene implicated in Alzheimer's disease; colorectal cancer; and schizophrenia. Is an ortholog of human ATF2 (activating transcription factor 2); ATF7 (activating transcription factor 7); and CREB5 (cAMP responsive element binding protein 5).
F49C12.11 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Expressed in coelomocyte; hypodermis; and neurons. Is predicted to encode a protein with the following domains: Translation machinery associated TMA7 and Phosphorylation site. Is an ortholog of human TMA7 (translation machinery associated 7 homolog).
dpy-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans A structural constituent of collagen and cuticulin-based cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle and post-embryonic body morphogenesis. Located in annular furrow extracellular matrix. Expressed in several structures, including P1; P12; P2; cuticle; and hypodermis. Used to study skin disease.
acl-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glycerol-3-phosphate O-acyltransferase activity and glycerone-phosphate O-acyltransferase activity. Predicted to be involved in cellular lipid metabolic process. Predicted to be located in mitochondrial membrane and peroxisomal membrane. Human ortholog(s) of this gene implicated in rhizomelic chondrodysplasia punctata type 2. Is an ortholog of human GNPAT (glyceronephosphate O-acyltransferase).
fat-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables stearoyl-CoA 9-desaturase activity. Involved in fatty acid biosynthetic process and post-embryonic development. Acts upstream of or within intracellular oxygen homeostasis and response to hypoxia. Predicted to be located in endoplasmic reticulum membrane. Expressed in intestinal cell. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 79. Is an ortholog of human SCD (stearoyl-CoA desaturase) and SCD5 (stearoyl-CoA desaturase 5).
exos-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in RNA metabolic process. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Expressed in motor neurons. Is an ortholog of human EXOSC7 (exosome component 7).
F23F1.6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable amino acid transmembrane transporter activity. Predicted to be involved in amino acid transport. Predicted to be located in plasma membrane. Is an ortholog of human SLC7A4 (solute carrier family 7 member 4).
B0454.6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable amino acid transmembrane transporter activity. Predicted to be involved in amino acid transport. Predicted to be located in plasma membrane. Is an ortholog of human SLC7A4 (solute carrier family 7 member 4).
snf-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Is an ortholog of human SLC6A7 (solute carrier family 6 member 7).
nas-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable metalloendopeptidase activity. Involved in pharyngeal pumping and pharynx development. Predicted to be located in extracellular region. Expressed in several structures, including arcade cell; hypodermis; pharyngeal cell; spermatheca; and vulva. Is an ortholog of human ASTL (astacin like metalloendopeptidase).
TMUE_2000010426 [Browse genome (BioProject PRJEB126)] [Search on AGR]
Trichuris muris Predicted to enable hydrolase activity. Predicted to be located in mitochondrion. Predicted to be part of respiratory chain complex IV. Is an ortholog of C. elegans
mig-23 and
ntp-1. In C. elegans,
mig-23 is involved in several processes, including gonad morphogenesis; positive regulation of protein glycosylation; and ribonucleoside diphosphate catabolic process.
snf-9 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Is an ortholog of human SLC6A7 (solute carrier family 6 member 7).
hil-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA binding activity. Predicted to be a structural constituent of chromatin. Predicted to be involved in nucleosome assembly. Predicted to be part of nucleosome. Expressed widely.
snf-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Is an ortholog of human SLC6A7 (solute carrier family 6 member 7).
Ovo-mig-13 [Browse genome (BioProject PRJEB513)] [Search on AGR]
Onchocerca volvulus Is predicted to encode a protein with the following domains: Spermadhesin, CUB domain superfamily; Low-density lipoprotein receptor domain class A; CUB domain; LDL receptor-like superfamily; and Low-density lipoprotein (LDL) receptor class A repeat. Is an ortholog of C. elegans
mig-13. In C. elegans,
mig-13 is involved in positive regulation of cell migration.
SRAE_2000235300 [Browse genome (BioProject PRJEB125)] [Search on AGR]
Strongyloides ratti Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in ribosome. Is an ortholog of C. elegans
mig-32. In C. elegans,
mig-32 is involved in several processes, including negative regulation of vulval development; nematode male tail tip morphogenesis; and regulation of axon extension involved in axon guidance.
sqv-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables UDP-N-acetylgalactosamine transmembrane transporter activity; UDP-galactose transmembrane transporter activity; and UDP-glucuronic acid transmembrane transporter activity. Involved in several processes, including egg-laying behavior; proteoglycan biosynthetic process; and pyrimidine nucleotide-sugar transmembrane transport. Located in cytoplasm. Expressed in hermaphrodite distal tip cell; oocyte; seam cell; and vulval cell. Human ortholog(s) of this gene implicated in schneckenbecken dysplasia. Is an ortholog of human SLC35D1 (solute carrier family 35 member D1).
gst-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glutathione transferase activity. Involved in innate immune response. Expressed in germ line; head; and hypodermis. Is an ortholog of human HPGDS (hematopoietic prostaglandin D synthase).
snr-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to contribute to RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Located in P granule. Expressed in gonad. Human ortholog(s) of this gene implicated in nasopharynx carcinoma. Is an ortholog of human SNRPG (small nuclear ribonucleoprotein polypeptide G).
rbm-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable single-stranded RNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in nucleus. Is an ortholog of human RBM7 (RNA binding motif protein 7).
Cbn-mig-13 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Is predicted to encode a protein with the following domains: Spermadhesin, CUB domain superfamily; Low-density lipoprotein receptor domain class A; CUB domain; LDL receptor-like superfamily; and Low-density lipoprotein (LDL) receptor class A repeat. Is an ortholog of C. elegans
mig-13. In C. elegans,
mig-13 is involved in positive regulation of cell migration.
Cre-mig-13 [Browse genome (BioProject PRJNA577507)] [Search on AGR]
Caenorhabditis remanei Is predicted to encode a protein with the following domains: Spermadhesin, CUB domain superfamily; Low-density lipoprotein receptor domain class A; CUB domain; LDL receptor-like superfamily; and Low-density lipoprotein (LDL) receptor class A repeat. Is an ortholog of C. elegans
mig-13. In C. elegans,
mig-13 is involved in positive regulation of cell migration.
arx-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable actin filament binding activity. Involved in Arp2/3 complex-mediated actin nucleation; epithelial cell migration; and morphogenesis of embryonic epithelium. Located in cytoplasm. Expressed in anchor cell; hypodermis; and linker cell. Human ortholog(s) of this gene implicated in lung squamous cell carcinoma. Is an ortholog of human ARPC5 (actin related protein 2/3 complex subunit 5) and ARPC5L (actin related protein 2/3 complex subunit 5 like).
Bma-mig-13 [Browse genome (BioProject PRJNA10729)] [Search on AGR]
Brugia malayi Is predicted to encode a protein with the following domains: Spermadhesin, CUB domain superfamily; Low-density lipoprotein receptor domain class A; CUB domain; LDL receptor-like superfamily; and Low-density lipoprotein (LDL) receptor class A repeat. Is an ortholog of C. elegans
mig-13. In C. elegans,
mig-13 is involved in positive regulation of cell migration.
Cbr-mig-13 [Browse genome (BioProject PRJNA10731)] [Search on AGR]
Caenorhabditis briggsae Is predicted to encode a protein with the following domains: Spermadhesin, CUB domain superfamily; Low-density lipoprotein receptor domain class A; CUB domain; LDL receptor-like superfamily; and Low-density lipoprotein (LDL) receptor class A repeat. Is an ortholog of C. elegans
mig-13. In C. elegans,
mig-13 is involved in positive regulation of cell migration.
fut-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable fucosyltransferase activity. Predicted to be involved in fucosylation. Predicted to be located in Golgi cisterna membrane. Is an ortholog of human FUT7 (fucosyltransferase 7).
Cjp-mig-13 [Browse genome (BioProject PRJNA12591)] [Search on AGR]
Caenorhabditis japonica Is predicted to encode a protein with the following domains: Spermadhesin, CUB domain superfamily; Low-density lipoprotein receptor domain class A; CUB domain; LDL receptor-like superfamily; and Low-density lipoprotein (LDL) receptor class A repeat. Is an ortholog of C. elegans
mig-13. In C. elegans,
mig-13 is involved in positive regulation of cell migration.
nepr-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in regulation of nuclear division. Predicted to be located in cytoplasm and nuclear membrane. Predicted to be part of Nem1-Spo7 phosphatase complex. Is an ortholog of human CNEP1R1 (CTD nuclear envelope phosphatase 1 regulatory subunit 1).
F32D8.14 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and vesicle fusion with Golgi apparatus. Predicted to be located in trans-Golgi network. Is an ortholog of human YIPF7 (Yip1 domain family member 7).
hum-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables calmodulin binding activity and plus-end directed microfilament motor activity. Involved in actin-myosin filament sliding. Predicted to be located in actin filament. Predicted to be part of myosin complex. Expressed in accessory cell; pharynx;
pm6;
pm7; and terminal bulb. Human ortholog(s) of this gene implicated in celiac disease and congenital myasthenic syndrome. Is an ortholog of human MYO9A (myosin IXA).
cdk-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin-dependent protein serine/threonine kinase activity. Involved in mRNA transcription and mitotic cell cycle, embryonic. Predicted to be located in cytoplasm and nucleus. Predicted to be part of transcription factor TFIIK complex. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is an ortholog of human CDK7 (cyclin dependent kinase 7).
dex-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable calcium ion binding activity. Involved in amphid sensory organ dendrite retrograde extension. Located in dendrite membrane. Expressed in several structures, including anterior deirid sensillum; excretory system; pharynx; rectum; and socket cell.
C50D2.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable amino acid transmembrane transporter activity. Predicted to be involved in amino acid transport. Predicted to be located in plasma membrane. Expressed in head. Is an ortholog of human SLC7A4 (solute carrier family 7 member 4).
cmtr-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable mRNA (nucleoside-2'-O-)-methyltransferase activity. Predicted to be involved in 7-methylguanosine mRNA capping and
cap1 mRNA methylation. Predicted to be located in cytoplasm and nucleus. Is an ortholog of human CMTR1 (cap methyltransferase 1).
T13C5.6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable sphingosine-1-phosphate phosphatase activity. Acts upstream of or within IRE1-mediated unfolded protein response. Predicted to be located in membrane. Is an ortholog of human PLPP6 (phospholipid phosphatase 6) and PLPP7 (phospholipid phosphatase 7 (inactive)).
ZK1128.1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable protein-arginine omega-N symmetric methyltransferase activity. Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrion. Is an ortholog of human NDUFAF7 (NADH:ubiquinone oxidoreductase complex assembly factor 7).
nekl-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable protein serine/threonine kinase activity. Involved in gonad development and molting cycle. Located in apical plasma membrane. Expressed in
hyp7 syncytium; hypodermal cell; neurons; and vulva. Is an ortholog of human NEK7 (NIMA related kinase 7).
Cre-mig-21 [Browse genome (BioProject PRJNA577507)] [Search on AGR]
Caenorhabditis remanei Is predicted to encode a protein with the following domains: Thrombospondin
type-1 (TSP1) repeat; Thrombospondin
type-1 (TSP1) repeat superfamily; and Thrombospondin type 1 domain. Is an ortholog of C. elegans
mig-21. In C. elegans,
mig-21 is involved in several processes, including cell migration; determination of left/right asymmetry in nervous system; and regulation of canonical Wnt signaling pathway.
Cre-mig-32 [Browse genome (BioProject PRJNA577507)] [Search on AGR]
Caenorhabditis remanei Is predicted to encode a protein with the following domains: Zinc finger, RING/FYVE/PHD-type and Zinc finger, C3HC4 type (RING finger). Is an ortholog of C. elegans
mig-32. In C. elegans,
mig-32 is involved in several processes, including negative regulation of vulval development; nematode male tail tip morphogenesis; and regulation of axon extension involved in axon guidance.
unc-34 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables signaling receptor binding activity. Involved in axon development; gonad morphogenesis; and positive regulation of locomotion. Located in several cellular components, including cell junction; cell leading edge; and filopodium tip. Expressed in epithelial cell. Used to study tauopathy. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Is an ortholog of human ENAH (ENAH actin regulator) and EVL (Enah/Vasp-like).
T02G5.3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in positive regulation of protein localization to ciliary membrane. Predicted to be located in ciliary membrane. Predicted to be part of plasma membrane protein complex. Is an ortholog of human EFCAB7 (EF-hand calcium binding domain 7).
tig-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable cytokine activity. Predicted to be involved in signal transduction. Predicted to be located in extracellular space. Expressed in cholinergic neurons; pharyngeal muscle cell; and touch receptor neurons. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and reproductive organ cancer (multiple). Is an ortholog of several human genes including BMP5 (bone morphogenetic protein 5); BMP7 (bone morphogenetic protein 7); and BMP8B (bone morphogenetic protein 8b).
aat-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); esophagitis; and glioblastoma. Is an ortholog of human SLC7A5 (solute carrier family 7 member 5) and SLC7A8 (solute carrier family 7 member 8).
hot-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in CEP socket cell; enteric muscle; head mesodermal cell; neurons; and ventral nerve cord based on tiling array; RNA-seq; single-cell RNA-seq; and microarray studies. Is affected by several genes including
sir-2.1;
lin-35; and
daf-1 based on RNA-seq and microarray studies. Is affected by nine chemicals including nicotinic acid; Psoralens; and allantoin based on RNA-seq and microarray studies.
dpy-19 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables mannosyltransferase activity. Predicted to be involved in carbohydrate metabolic process; cell differentiation; and nervous system development. Located in perinuclear region of cytoplasm. Expressed in several structures, including P1; P2; QL; QR; and seam cell. Human ortholog(s) of this gene implicated in spermatogenic failure 9. Is an ortholog of human DPY19L2 (
dpy-19 like 2).
abi-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables SH3 domain binding activity and protein kinase binding activity. Involved in several processes, including positive regulation of endocytosis; presynaptic actin cytoskeleton organization; and synaptic vesicle clustering. Located in axon; cytoplasm; and somatodendritic compartment. Expressed in coelomocyte; head neurons; and ventral cord neurons. Is an ortholog of human ABI1 (abl interactor 1).
Cjp-mig-32 [Browse genome (BioProject PRJNA12591)] [Search on AGR]
Caenorhabditis japonica Is predicted to encode a protein with the following domains: Zinc finger, RING-type; Zinc finger, RING/FYVE/PHD-type; and Zinc finger, C3HC4 type (RING finger). Is an ortholog of C. elegans
mig-32. In C. elegans,
mig-32 is involved in several processes, including negative regulation of vulval development; nematode male tail tip morphogenesis; and regulation of axon extension involved in axon guidance.
Cbr-mig-32 [Browse genome (BioProject PRJNA10731)] [Search on AGR]
Caenorhabditis briggsae Is predicted to encode a protein with the following domains: Zinc finger, RING-type; Zinc finger, RING/FYVE/PHD-type; and Zinc finger, C3HC4 type (RING finger). Is an ortholog of C. elegans
mig-32. In C. elegans,
mig-32 is involved in several processes, including negative regulation of vulval development; nematode male tail tip morphogenesis; and regulation of axon extension involved in axon guidance.
F27D9.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 7. Is an ortholog of human MFSD8 (major facilitator superfamily domain containing 8).
W03C9.6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 7. Is an ortholog of human MFSD8 (major facilitator superfamily domain containing 8).
C25E10.5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 7. Is an ortholog of human MFSD8 (major facilitator superfamily domain containing 8).
F52F10.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 7. Is an ortholog of human MFSD8 (major facilitator superfamily domain containing 8).
mfsd-8 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 7. Is an ortholog of human MFSD8 (major facilitator superfamily domain containing 8).
pbs-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable endopeptidase activity. Predicted to be involved in proteasomal protein catabolic process. Predicted to be located in nucleus. Predicted to be part of proteasome core complex, beta-subunit complex. Is an ortholog of human PSMB7 (proteasome 20S subunit beta 7).
W05E10.1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 7. Is an ortholog of human MFSD8 (major facilitator superfamily domain containing 8).
ZK563.7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable GDP phosphatase activity and UDP phosphatase activity. Predicted to be involved in proteoglycan biosynthetic process. Human ortholog(s) of this gene implicated in Desbuquois dysplasia and multiple epiphyseal dysplasia 7. Is an ortholog of human CANT1 (calcium activated nucleotidase 1).
cmtr-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable mRNA (nucleoside-2'-O-)-methyltransferase activity. Predicted to be involved in 7-methylguanosine mRNA capping;
cap1 mRNA methylation; and
cap2 mRNA methylation. Predicted to be located in cytoplasm and nucleus. Is an ortholog of human CMTR2 (cap methyltransferase 2).
F14D12.1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable protein kinase binding activity. Predicted to be involved in neuromuscular junction development. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 10 and fetal akinesia deformation sequence syndrome 3. Is an ortholog of human DOK7 (docking protein 7).
F57A8.7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 7. Is an ortholog of human MFSD8 (major facilitator superfamily domain containing 8).
snb-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable SNAP receptor activity and syntaxin binding activity. Predicted to be involved in vesicle fusion. Predicted to be located in plasma membrane. Predicted to be part of SNARE complex. Is an ortholog of human VAMP7 (vesicle associated membrane protein 7).
F14D7.6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 7. Is an ortholog of human MFSD8 (major facilitator superfamily domain containing 8).
T28C12.1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 7. Is an ortholog of human MFSD8 (major facilitator superfamily domain containing 8).
T28C12.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 7. Is an ortholog of human MFSD8 (major facilitator superfamily domain containing 8).
W01B6.3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 7. Is an ortholog of human MFSD8 (major facilitator superfamily domain containing 8).
ZK550.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 7. Is an ortholog of human MFSD8 (major facilitator superfamily domain containing 8).
F58G11.4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 7. Is an ortholog of human MFSD8 (major facilitator superfamily domain containing 8).
snb-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable SNAP receptor activity and syntaxin binding activity. Predicted to be involved in vesicle fusion. Predicted to be located in plasma membrane. Predicted to be part of SNARE complex. Is an ortholog of human VAMP7 (vesicle associated membrane protein 7).
Y47C4A.1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable metalloendopeptidase activity. Predicted to be involved in mitochondrial protein processing. Predicted to be part of m-AAA complex. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 7. Is an ortholog of human SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin).
F39B2.5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process. Predicted to be part of phosphatidylinositol 3-kinase complex. Is an ortholog of human SOCS6 (suppressor of cytokine signaling 6) and SOCS7 (suppressor of cytokine signaling 7).
tmed-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Predicted to be located in intracellular membrane-bounded organelle. Is an ortholog of human TMED7 (transmembrane
p24 trafficking protein 7) and TMED7-TICAM2 (TMED7-TICAM2 readthrough).
sulp-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable salt transmembrane transporter activity. Predicted to be involved in inorganic anion transmembrane transport and organic anion transport. Predicted to be located in membrane. Expressed in body wall musculature; hypodermis; intestine; pharyngeal muscle cell; and vulval muscle. Human ortholog(s) of this gene implicated in several diseases, including Pendred Syndrome; autosomal recessive nonsyndromic deafness (multiple); and bone disease (multiple). Is an ortholog of several human genes including SLC26A2 (solute carrier family 26 member 2); SLC26A3 (solute carrier family 26 member 3); and SLC26A4 (solute carrier family 26 member 4).
unc-73 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in several processes, including cellular component organization; modulation of chemical synaptic transmission; and positive regulation of protein localization to synapse. Located in axon; cytoplasm; and muscle cell projection. Expressed in several structures, including egg-laying apparatus; hermaphrodite gonad; lumbar ganglion; neurons; and tail hypodermis. Used to study epilepsy. Human ortholog(s) of this gene implicated in artery disease (multiple); autosomal dominant intellectual developmental disorder 44; and cerebral infarction. Is an ortholog of human KALRN (kalirin RhoGEF kinase) and TRIO (trio Rho guanine nucleotide exchange factor).
mut-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 3'-5'-exoribonuclease activity involved in mature miRNA 3'-end processing. Involved in obsolete negative regulation of transposition, DNA-mediated; olfactory learning; and regulatory ncRNA-mediated post-transcriptional gene silencing. Located in cytosol; mutator focus; and nucleus. Expressed in AWCL; AWCR; and somatic cell. Is an ortholog of human EXD3 (exonuclease 3'-5' domain containing 3).
rgs-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables GTPase activator activity. Predicted to be involved in negative regulation of signal transduction. Located in cell cortex. Is an ortholog of several human genes including RGS1 (regulator of G protein signaling 1); RGS13 (regulator of G protein signaling 13); and RGS4 (regulator of G protein signaling 4).
C38D9.5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in germ line based on RNA-seq studies. Is affected by several genes including
daf-16;
daf-2; and
let-7 based on RNA-seq; microarray; and proteomic studies. Is affected by five chemicals including cholesterol; Doxycycline; and paraquat based on RNA-seq and microarray studies.
Y48A5A.3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in mitochondrial respiratory chain complex III assembly. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 7. Is an ortholog of human UQCC2 (ubiquinol-cytochrome c reductase complex assembly factor 2).
Su(var)3-7 [Search on AGR]
Drosophila melanogaster Suppressor of variegation 3-7 (Su(var)3-7) encodes a protein associated with heterochromatin. Increasing the amount of the product of Su(var)3-7 triggers heterochromatin expansion and epigenetic gene silencing.
noca-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in microtubule anchoring at centrosome. Predicted to be located in centrosome. Expressed in PVDL; PVDR; head; seam cell; and tail. Human ortholog(s) of this gene implicated in Seckel syndrome 7. Is an ortholog of human NIN (ninein) and NINL (ninein like).
ZC434.4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in rRNA processing and ribosomal small subunit assembly. Predicted to be part of CURI complex and UTP-C complex. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Is an ortholog of human RRP7A (ribosomal RNA processing 7 homolog A).
B0024.11 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable pseudouridine synthase activity. Predicted to be involved in pseudouridine synthesis. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in intellectual developmental disorder with abnormal behavior, microcephaly, and short stature. Is an ortholog of human PUS7 (pseudouridine synthase 7).
ccf-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable poly(A)-specific ribonuclease activity. Involved in nuclear-transcribed mRNA poly(A) tail shortening and oogenesis. Located in P granule and P-body. Part of CCR4-NOT complex. Expressed in germ line. Is an ortholog of human CNOT7 (CCR4-NOT transcription complex subunit 7).
E03A3.10 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in somatic gonad precursor based on RNA-seq studies. Is affected by several genes including
rrf-3;
clk-1; and
dpy-7 based on microarray and RNA-seq studies. Is affected by seven chemicals including 1-methylnicotinamide; Psoralens; and allantoin based on RNA-seq studies.
sws-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in double-strand break repair via homologous recombination. Predicted to be part of Shu complex. Human ortholog(s) of this gene implicated in 46 XX gonadal dysgenesis and spermatogenic failure. Is an ortholog of human ZSWIM7 (zinc finger SWIM-type containing 7).
tars-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable threonine-tRNA ligase activity. Involved in determination of adult lifespan. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 21 and nonphotosensitive trichothiodystrophy 7. Is an ortholog of human TARS3 (threonyl-tRNA synthetase 3).
C35A5.8 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable nuclear export signal receptor activity. Predicted to be involved in protein export from nucleus. Predicted to be located in cytoplasm. Predicted to be part of nuclear pore. Expressed widely. Is an ortholog of human RANBP17 (RAN binding protein 17) and XPO7 (exportin 7).
Cbr-mig-21 [Browse genome (BioProject PRJNA10731)] [Search on AGR]
Caenorhabditis briggsae Is affected by
Cbr-spr-4 based on RNA-seq studies. Is predicted to encode a protein with the following domains: Thrombospondin
type-1 (TSP1) repeat; Thrombospondin
type-1 (TSP1) repeat superfamily; and Thrombospondin type 1 domain. Is an ortholog of C. elegans
mig-21. In C. elegans,
mig-21 is involved in several processes, including cell migration; determination of left/right asymmetry in nervous system; and regulation of canonical Wnt signaling pathway.
F13B12.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable hexose transmembrane transporter activity. Predicted to be involved in monosaccharide transmembrane transport. Predicted to be located in membrane. Is an ortholog of human SLC2A11 (solute carrier family 2 member 11); SLC2A7 (solute carrier family 2 member 7); and SLC2A9 (solute carrier family 2 member 9).
F49D11.4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in AVHL and AVHR based on single-cell RNA-seq studies. Is affected by several genes including
sir-2.1;
clk-1; and
dpy-7 based on RNA-seq and microarray studies. Is affected by eight chemicals including Tunicamycin; Zidovudine; and Psoralens based on microarray and RNA-seq studies.
vig-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA binding activity. Part of RISC complex. Expressed in neurons. Is an ortholog of human HABP4 (hyaluronan binding protein 4) and SERBP1 (SERPINE1 mRNA binding protein 1).
F19H6.5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in male based on RNA-seq studies. Is affected by several genes including
daf-2;
rrf-3; and
let-7 based on microarray; tiling array; and RNA-seq studies. Is affected by nine chemicals including methylmercuric chloride; Tunicamycin; and stavudine based on microarray and RNA-seq studies.
snb-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable SNAP receptor activity and syntaxin binding activity. Predicted to be involved in vesicle fusion. Predicted to be located in plasma membrane. Predicted to be part of SNARE complex. Is an ortholog of human VAMP7 (vesicle associated membrane protein 7).
mcm-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable single-stranded DNA binding activity. Predicted to contribute to single-stranded DNA helicase activity. Involved in MCM complex assembly; embryo development; and mitotic sister chromatid segregation. Predicted to be located in nucleus. Predicted to be part of MCM complex. Expressed in several structures, including anchor cell; intestine; tail; uterine epithelial cell; and vulval precursor cell. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and pancreatic ductal carcinoma. Is an ortholog of human MCM7 (minichromosome maintenance complex component 7).
alh-9 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in cellular aldehyde metabolic process. Expressed in ABa and seam cell. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and pyridoxine-dependent epilepsy. Is an ortholog of human ALDH7A1 (aldehyde dehydrogenase 7 family member A1).
syx-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in intracellular protein transport; vesicle docking; and vesicle fusion. Predicted to be located in synaptic vesicle. Predicted to be part of SNARE complex. Is an ortholog of human STX12 (syntaxin 12) and STX7 (syntaxin 7).
CE7X_3.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in DA neuron; VA neuron; and intestine based on tiling array studies. Is affected by several genes including
daf-16;
hsf-1; and
let-7 based on microarray; proteomic; and RNA-seq studies. Is affected by eleven chemicals including Alovudine; stavudine; and Zidovudine based on RNA-seq studies.
snf-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in plasma membrane. Expressed in amphid neurons; intestinal cell; pharyngeal neurons; and rectal gland cell. Is an ortholog of human SLC6A7 (solute carrier family 6 member 7).
rho-7 [Search on AGR]
Drosophila melanogaster rhomboid-7 (
rho-7) encodes an intramembrane serine protease of the rhomboid family present in the inner membrane of mitochondria. It regulates mitochondrial fusion during spermatogenesis and muscle development.
rho-7 genetically interacts with fog, Opa1 and Pink1.
Mtl [Search on AGR]
Drosophila melanogaster Mig-2-like (Mtl) encodes a Rho GTPase involved in actin organization regulation. It contributes to multiple actin-mediated processes including dorsal closure, wound healing, cell migration, germ band shortening and salivary gland morphogenesis.
TMUE_1000005646 [Browse genome (BioProject PRJEB126)] [Search on AGR]
Trichuris muris Is predicted to encode a protein with the following domains: Zinc finger, C3HC4 type (RING finger); RAWUL domain; Zinc finger, RING-type; Zinc finger, RING/FYVE/PHD-type; and RAWUL domain RING finger- and WD40-associated ubiquitin-like. Is an ortholog of C. elegans
mig-32. In C. elegans,
mig-32 is involved in several processes, including negative regulation of vulval development; nematode male tail tip morphogenesis; and regulation of axon extension involved in axon guidance.
K10C9.9 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in ASER and muscle cell based on RNA-seq studies. Is affected by several genes including
rrf-3;
eat-2; and
dpy-7 based on RNA-seq and microarray studies. Is affected by nine chemicals including tryptophan; Tunicamycin; and multi-walled carbon nanotube based on microarray and RNA-seq studies.
Y48E1C.4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in germ line and somatic gonad precursor based on RNA-seq studies. Is affected by several genes including
daf-16;
daf-2; and
let-7 based on proteomic; RNA-seq; and microarray studies. Is affected by eight chemicals including rotenone; stavudine; and Rifampin based on RNA-seq and microarray studies.
mrps-22 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be a structural constituent of ribosome. Predicted to be located in ribosome. Predicted to be part of mitochondrial small ribosomal subunit. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 5 and ovarian dysgenesis 7. Is an ortholog of human MRPS22 (mitochondrial ribosomal protein S22).
rba-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable histone binding activity. Involved in cell fate specification; nematode male tail tip morphogenesis; and regulation of neurogenesis. Predicted to be located in nucleus. Predicted to be part of ESC/E(Z) complex and NuRD complex. Is an ortholog of human RBBP7 (RB binding protein 7, chromatin remodeling factor).
CRE29632 [Browse genome (BioProject PRJNA577507)] [Search on AGR]
Caenorhabditis remanei Is predicted to encode a protein with the following domains: Ribosomal RNA-processing protein 7; Ribosomal RNA-processing protein 7, C-terminal domain; and Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain. Is an ortholog of C. elegans ZC434.4.
T23B5.4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable translation release factor activity. Predicted to be involved in translational termination. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 7 and hereditary spastic paraplegia 55. Is an ortholog of human MTRFR (mitochondrial translation release factor in rescue).
cdc-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including endocytosis; positive regulation of canonical Wnt signaling pathway; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in nucleus. Is an ortholog of human CDC7 (cell division cycle 7).
K12H4.5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in AFD; ASER; and PLM based on RNA-seq and microarray studies. Is affected by several genes including
daf-16;
hsf-1; and
let-7 based on microarray; RNA-seq; and proteomic studies. Is affected by six chemicals including rotenone; Rifampin; and allantoin based on RNA-seq and microarray studies.