Enables choline kinase activity. Involved in CDP-choline pathway and IRE1-mediated unfolded protein response. Predicted to be located in cytoplasm. Expressed in head and tail. Human ortholog(s) of this gene implicated in several diseases, including colon adenoma; megaconial type congenital muscular dystrophy; narcolepsy; and recurrent hypersomnia. Is an ortholog of human CHKA (choline kinase alpha) and CHKB (choline kinase beta).
PHENOTYPE: Mice heterozygous for a null allele exhibit increased colon tumor in Apc<sup>Min</sup>. Mice homozygous for a conditional allele activated in the colon exhibit increased sensitivity to AOM/DSS-induced tumors. [provided by MGI curators]