- myo-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans A structural constituent of muscle. Involved in muscle contraction and pharyngeal pumping. Located in striated muscle myosin thick filament. Expressed in pharynx. Human ortholog(s) of this gene implicated in several diseases, including contractures, pterygia, and spondylocarpotarsal fusion syndrome 1A; distal myopathy 1; and intrinsic cardiomyopathy (multiple). Is an ortholog of several human genes including MYH1 (myosin heavy chain 1); MYH2 (myosin heavy chain 2); and MYH3 (myosin heavy chain 3).
- myo-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in muscle contraction and sarcomere organization. Predicted to be located in cytoplasm and myosin filament. Predicted to be part of myosin II complex. Human ortholog(s) of this gene implicated in several diseases, including congenital heart disease (multiple); distal myopathy 1; and intrinsic cardiomyopathy (multiple). Is an ortholog of several human genes including MYH1 (myosin heavy chain 1); MYH2 (myosin heavy chain 2); and MYH3 (myosin heavy chain 3).
- myo-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in muscle contraction and sarcomere organization. Predicted to be located in cytoplasm and myosin filament. Predicted to be part of myosin II complex. Human ortholog(s) of this gene implicated in several diseases, including congenital heart disease (multiple); distal myopathy 1; and intrinsic cardiomyopathy (multiple). Is an ortholog of several human genes including MYH1 (myosin heavy chain 1); MYH2 (myosin heavy chain 2); and MYH3 (myosin heavy chain 3).
- myo-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in muscle contraction and sarcomere organization. Predicted to be located in cytoplasm and myosin filament. Predicted to be part of muscle myosin complex. Expressed in neurons and pharynx. Human ortholog(s) of this gene implicated in several diseases, including congenital heart disease (multiple); distal myopathy 1; and intrinsic cardiomyopathy (multiple). Is an ortholog of several human genes including MYH1 (myosin heavy chain 1); MYH2 (myosin heavy chain 2); and MYH3 (myosin heavy chain 3).
- myo-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables cytoskeletal motor activity. Involved in locomotory behavior and positive regulation of ovulation. Located in A band and striated muscle myosin thick filament. Expressed in body wall musculature; enteric muscle; gonad; vulval muscle; and in male. Human ortholog(s) of this gene implicated in several diseases, including congenital heart disease (multiple); distal myopathy 1; and intrinsic cardiomyopathy (multiple). Is an ortholog of several human genes including MYH1 (myosin heavy chain 1); MYH2 (myosin heavy chain 2); and MYH3 (myosin heavy chain 3).
- unc-54 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables actin filament binding activity and microfilament motor activity. A structural constituent of muscle. Involved in several processes, including egg-laying behavior; muscle contraction; and skeletal muscle myosin thick filament assembly. Located in A band and striated muscle myosin thick filament. Part of muscle myosin complex. Expressed in anal depressor muscle; body wall musculature; head; vulval muscle; and in male. Human ortholog(s) of this gene implicated in several diseases, including congenital heart disease (multiple); distal myopathy 1; and intrinsic cardiomyopathy (multiple). Is an ortholog of several human genes including MYH1 (myosin heavy chain 1); MYH2 (myosin heavy chain 2); and MYH3 (myosin heavy chain 3).