sknr-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; liver disease (multiple); obesity; and pulmonary emphysema. Is an ortholog of several human genes including NFE2 (nuclear factor, erythroid 2); NFE2L1 (NFE2 like bZIP transcription factor 1); and NFE2L2 (NFE2 like bZIP transcription factor 2).
skn-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables Hsp70 protein binding activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including endoderm development; endoplasmic reticulum unfolded protein response; and positive regulation of macromolecule biosynthetic process. Located in endoplasmic reticulum; mitochondrion; and nucleus. Expressed in several structures, including germ line; head ganglion; intestine; neurons; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; liver disease (multiple); obesity; and pulmonary emphysema. Is an ortholog of several human genes including NFE2 (nuclear factor, erythroid 2); NFE2L1 (NFE2 like bZIP transcription factor 1); and NFE2L2 (NFE2 like bZIP transcription factor 2).