ncr-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable cholesterol binding activity. Involved in several processes, including cholesterol homeostasis; positive regulation of growth rate; and regulation of egg-laying behavior. Predicted to be located in late endosome; lysosome; and plasma membrane. Expressed in several structures, including excretory cell; head neurons; hypodermis; lumbar neurons; and pharynx. Used to study Niemann-Pick disease. Human ortholog(s) of this gene implicated in Niemann-Pick disease type C1. Is an ortholog of human NPC1 (NPC intracellular cholesterol transporter 1).
NIC96 [Search on AGR]
Saccharomyces cerevisiae Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p)
Nup188 [Search on AGR]
Saccharomyces cerevisiae Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
POM34 [Search on AGR]
Saccharomyces cerevisiae Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication
NUP192 [Search on AGR]
Saccharomyces cerevisiae Essential subunit of inner ring of nuclear pore complex (NPC); plays a role in modulating transport through the NPC; homologous to human NUP205
NDC1 [Search on AGR]
Saccharomyces cerevisiae Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1
NUP82 [Search on AGR]
Saccharomyces cerevisiae Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup159p, and Nup116p); relocalizes to the cytosol in response to hypoxia
heh-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable sterol binding activity. Predicted to be involved in sterol transport. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in Niemann-Pick disease type C2. Is an ortholog of human NPC2 (NPC intracellular cholesterol transporter 2).
ncr-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable cholesterol binding activity. Involved in cholesterol homeostasis; cholesterol transport; and nematode larval development. Predicted to be located in plasma membrane. Expressed in XXXL; XXXR; gonadal sheath cell; spermatheca; and ventral nerve cord. Used to study Niemann-Pick disease. Human ortholog(s) of this gene implicated in Niemann-Pick disease type C1. Is an ortholog of human NPC1 (NPC intracellular cholesterol transporter 1).
NUP157 [Search on AGR]
Saccharomyces cerevisiae Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and tethering of DNA to the nuclear periphery; both Nup170p and NUP157p are similar to human Nup155p; NUP157 has a paralog, NUP170, that arose from the whole genome duplication
NUP1 [Search on AGR]
Saccharomyces cerevisiae FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of thenuclear pore complex (NPC) permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153
NUP84 [Search on AGR]
Saccharomyces cerevisiae Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP107
Nup42 [Search on AGR]
Saccharomyces cerevisiae FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex (NPC) cytoplasmic filaments; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; interacts with Gle1p; human homolog NUP42 can complement yeast mutant
NUP53 [Search on AGR]
Saccharomyces cerevisiae FG-nucleoporin component of central core of nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport; involved in regulation of transcription and mitosis; induces membrane tubulation, which may contribute to nuclear pore assembly; NUP53 has a paralog, ASM4, that arose from the whole genome duplication
Nup133 [Search on AGR]
Saccharomyces cerevisiae Subunit of Nup84p subcomplex of nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis; is involved in establishment of a normal nucleocytoplasmic concentration gradient of GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at nuclear periphery, including double-strand break repair, transcription and chromatin silencing; relocalizes to cytosol in response to hypoxia; homolog of human NUP133
NUP170 [Search on AGR]
Saccharomyces cerevisiae Subunit of inner ring of nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; interacts with genomic regions that contain ribosomal protein and subtelomeric genes, where it functions in nucleosome positioning and as a repressor of transcription; both Nup170p and Nup157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
NSP1 [Search on AGR]
Saccharomyces cerevisiae FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex (NPC) nuclear basket; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nup82p, Gle2p and two other FG-nucleoporins (Nup159p and Nup116p); also found in stable complex with Nic96p and two other FG-nucleoproteins (Nup49p and Nup57p)
NUP120 [Search on AGR]
Saccharomyces cerevisiae Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP160
NUP145 [Search on AGR]
Saccharomyces cerevisiae Essential protein with distinct roles in two nuclear pore subcomplexes; catalyzes its own proteolytic cleavage in vivo to generate a C-terminal fragment that is a structural component of the Nup84p subcomplex (with roles in NPC biogenesis and localization of genes to the nuclear periphery), and an N-terminal fragment that is one of several FG-nucleoporins within the NPC central core directly responsible for nucleocytoplasmic transport; homologous to human NUP98
Nup107 [Search on AGR]
Homo sapiens This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Nup85 [Search on AGR]
Saccharomyces cerevisiae Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75
Nup58 [Search on AGR]
Homo sapiens This gene encodes a member of the nucleoporin family that shares 87% sequence identity with rat nucleoporin
p58. The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
GLE2 [Search on AGR]
Saccharomyces cerevisiae RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1
POM33 [Search on AGR]
Saccharomyces cerevisiae Transmembrane nucleoporin; involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p; protein abundance increases in response to DNA replication stress
NUP49 [Search on AGR]
Saccharomyces cerevisiae FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p)
Knl1 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E6. Mice homozygous for a conditional allele activated in NPCs exhibit postnatal and premature death and microcephaly associated with NPC apoptosis and premature differentiation. [provided by MGI curators]
NUP57 [Search on AGR]
Saccharomyces cerevisiae FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p)
ASM4 [Search on AGR]
Saccharomyces cerevisiae FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore assembly; ASM4 has a paralog, NUP53, that arose from the whole genome duplication
ima-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables DNA-binding transcription factor binding activity; nuclear import signal receptor activity; and nuclear localization sequence binding activity. Involved in several processes, including NLS-bearing protein import into nucleus; cellular component organization; and nematode larval development. Located in cytoplasm and nuclear envelope. Part of nuclear pore. Expressed in germ line; gonad; hypodermis; muscle cell; and neurons. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 88. Is an ortholog of human KPNA3 (karyopherin subunit alpha 3) and KPNA4 (karyopherin subunit alpha 4).
EPL1 [Search on AGR]
Saccharomyces cerevisiae Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb; coding sequence contains length polymorphisms in different strains
POM152 [Search on AGR]
Saccharomyces cerevisiae Glycoprotein subunit of transmembrane ring of nuclear pore complex; contributes to nucleocytoplasmic transport, nuclear pore complex (NPC) biogenesis and spindle pole body duplication; type II transmembrane protein composed of N-terminal cytosolic and C-terminal nuclear envelope lumenal domains; homologous to human NUP210
Nup188 [Search on AGR]
Homo sapiens The nuclear pore complex (NPC) is found on the nuclear envelope and forms a gateway that regulates the flow of proteins and RNAs between the cytoplasm and nucleoplasm. The NPC is comprised of approximately 30 distinct proteins collectively known as nucleoporins. Nucleoporins are pore-complex-specific glycoproteins which often have cytoplasmically oriented O-linked N-acetylglucosamine residues and numerous repeats of the pentapeptide sequence XFXFG. However, the nucleoporin protein encoded by this gene does not contain the typical FG repeat sequences found in most vertebrate nucleoporins. This nucleoporin is thought to form part of the scaffold for the central channel of the nuclear pore. [provided by RefSeq, Jan 2013]
NUP100 [Search on AGR]
Saccharomyces cerevisiae FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier and is involved in gene tethering at the nuclear periphery; NUP100 has a paralog, NUP116, that arose from the whole genome duplication
NUP159 [Search on AGR]
Saccharomyces cerevisiae FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex (NPC) cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p)
NUP116 [Search on AGR]
Saccharomyces cerevisiae FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup159p); NUP116 has a paralog, NUP100, that arose from the whole genome duplication
Npc1 [Search on AGR]
Rattus norvegicus Predicted to enable cholesterol binding activity. Involved in negative regulation of epithelial cell apoptotic process and response to cadmium ion. Predicted to be located in several cellular components, including lysosomal membrane; membrane raft; and perinuclear region of cytoplasm. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in Niemann-Pick disease type C1. Orthologous to human NPC1 (NPC intracellular cholesterol transporter 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
ify-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables protease binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including cortical granule exocytosis; nuclear division; and protein stabilization. Located in condensed chromosome; cytoplasm; and spindle microtubule. Expressed in germ cell.
T04F3.1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable transaminase activity. Predicted to be involved in amino acid metabolic process. Is an ortholog of human ACCS (1-aminocyclopropane-1-carboxylate synthase homolog (inactive)) and ACCSL (1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like).
tpr [Search on AGR]
Homo sapiens This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]
ape-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables
p53 binding activity. Involved in negative regulation of apoptotic process. Predicted to be located in cytoplasm and nucleus. Expressed in several structures, including neurons and ventral nerve cord. Is an ortholog of human PPP1R13B (protein phosphatase 1 regulatory subunit 13B) and TP53BP2 (tumor protein
p53 binding protein 2).
sna-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable transcription coactivator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of core mediator complex and mediator complex. Expressed in several structures, including germ cell and somatic cell.
brd-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables ubiquitin protein ligase activity. Involved in DNA repair and protein ubiquitination. Part of BRCA1-BARD1 complex. Human ortholog(s) of this gene implicated in breast cancer and ovarian cancer. Is an ortholog of human BARD1 (BRCA1 associated RING domain 1).
asd-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables single-stranded RNA binding activity. Predicted to be involved in nervous system development and regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in cytoplasm and nucleus. Expressed in body wall musculature; intestine; nervous system; and vulval muscle. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; hypoplastic left heart syndrome; myotonic dystrophy type 1; and type 2 diabetes mellitus. Is an ortholog of human RBFOX1 (RNA binding
fox-1 homolog 1); RBFOX2 (RNA binding
fox-1 homolog 2); and RBFOX3 (RNA binding
fox-1 homolog 3).
git-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable GTPase activator activity and small GTPase binding activity. Involved in gonad morphogenesis and inductive cell migration. Located in hemidesmosome and presynaptic active zone. Human ortholog(s) of this gene implicated in Huntington's disease and attention deficit hyperactivity disorder. Is an ortholog of human GIT2 (GIT ArfGAP 2).
mpz-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables GTPase activating protein binding activity. Located in axon. Expressed in body wall musculature; nerve ring; neurons; and vulval muscle. Human ortholog(s) of this gene implicated in hydrocephalus. Is an ortholog of human MPDZ (multiple PDZ domain crumbs cell polarity complex component) and PATJ (PATJ crumbs cell polarity complex component).
ajm-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable cytoskeletal protein binding activity. Involved in cell-cell junction organization and embryo development. Located in apicolateral plasma membrane; cell-cell junction; and plasma membrane bounded cell projection. Expressed in several structures, including arcade cell and epithelial cell. Is an ortholog of human AJM1 (apical junction component 1 homolog).
Nup37 [Search on AGR]
Homo sapiens Nuclear pore complexes (NPCs) are used for transporting macromolecules between the cytoplasm and the nucleus. NPCs consist of multiple copies of 30 distinct proteins (nucleoporins), which assemble into biochemically-separable subcomplexes. The protein encoded by this gene is part of a subcomplex (Nup107-160) that is required for proper NPC function as well as for normal kinetochore-microtubule interaction and mitosis. [provided by RefSeq, Dec 2015]
dylt-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be located in cytoplasm. Predicted to be part of cytoplasmic dynein complex. Expressed in ADFL and ADFR. Is an ortholog of human DYNLT1 (dynein light chain Tctex-type 1) and DYNLT3 (dynein light chain Tctex-type 3).
apg-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable clathrin adaptor activity. Involved in apical protein localization and protein secretion. Predicted to be located in Golgi apparatus; cytoplasmic vesicle; and membrane. Predicted to be part of AP-1 adaptor complex. Is an ortholog of human AP1G1 (adaptor related protein complex 1 subunit gamma 1).