Predicted to enable cholesterol binding activity. Involved in several processes, including cholesterol homeostasis; positive regulation of growth rate; and regulation of egg-laying behavior. Predicted to be located in late endosome; lysosome; and plasma membrane. Expressed in several structures, including excretory cell; head neurons; hypodermis; lumbar neurons; and pharynx. Used to study Niemann-Pick disease. Human ortholog(s) of this gene implicated in Niemann-Pick disease type C1. Is an ortholog of human NPC1 (NPC intracellular cholesterol transporter 1).
Predicted to enable sterol binding activity. Predicted to be involved in sterol transport. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in Niemann-Pick disease type C2. Is an ortholog of human NPC2 (NPC intracellular cholesterol transporter 2).
Predicted to enable cholesterol binding activity. Involved in cholesterol homeostasis; cholesterol transport; and nematode larval development. Predicted to be located in plasma membrane. Expressed in XXXL; XXXR; gonadal sheath cell; spermatheca; and ventral nerve cord. Used to study Niemann-Pick disease. Human ortholog(s) of this gene implicated in Niemann-Pick disease type C1. Is an ortholog of human NPC1 (NPC intracellular cholesterol transporter 1).
Enables DNA-binding transcription factor binding activity; nuclear import signal receptor activity; and nuclear localization sequence binding activity. Involved in several processes, including NLS-bearing protein import into nucleus; cellular component organization; and nematode larval development. Located in cytoplasm and nuclear envelope. Part of nuclear pore. Expressed in germ line; gonad; hypodermis; muscle cell; and neurons. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 88. Is an ortholog of human KPNA3 (karyopherin subunit alpha 3) and KPNA4 (karyopherin subunit alpha 4).