- pdr-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables ubiquitin conjugating enzyme binding activity. Contributes to ubiquitin-protein transferase activity. Involved in several processes, including determination of adult lifespan; negative regulation of engulfment of apoptotic cell; and protein metabolic process. Located in mitochondrial outer membrane and neuronal cell body. Part of ubiquitin ligase complex. Expressed in muscle cell and neurons. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Lewy body dementia; Parkinson's disease 2; and female reproductive organ cancer (multiple). Is an ortholog of human PRKN (parkin RBR E3 ubiquitin protein ligase).
- F21G4.6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable kinase activity. Predicted to be involved in phosphorylation. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in Huntington's disease and Parkinson's disease. Is an ortholog of human HTT (huntingtin).
- mtp-18 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in mitochondrial fission. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in Parkinson's disease 6 and neuroblastoma. Is an ortholog of human MTFP1 (mitochondrial fission process 1).
- phac-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable actin binding activity. Predicted to be involved in actin cytoskeleton organization. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; developmental and epileptic encephalopathy 70; and multiple sclerosis. Is an ortholog of human PHACTR4 (phosphatase and actin regulator 4).
- C02D5.4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glutathione dehydrogenase (ascorbate) activity and glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and asthma. Is an ortholog of human GSTO1 (glutathione S-transferase omega 1) and GSTO2 (glutathione S-transferase omega 2).
- vps-13 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in protein retention in Golgi apparatus and protein targeting to vacuole. Predicted to be extrinsic component of membrane. Expressed in vulval muscle. Human ortholog(s) of this gene implicated in Parkinson's disease 23; choreaacanthocytosis; and choreatic disease. Is an ortholog of human VPS13A (vacuolar protein sorting 13 homolog A).