Enables ubiquitin binding activity. Involved in protein localization to non-motile cilium. Located in early endosome and endosome membrane. Part of ESCRT-0 complex. Expressed in several structures, including coelomocyte; excretory canal; hermaphrodite gonad; intestine; and vulva. Is an ortholog of human HGS (hepatocyte growth factor-regulated tyrosine kinase substrate).
Predicted to enable chitin binding activity. Involved in endoplasmic reticulum unfolded protein response. Predicted to be located in extracellular region.
Enables cohesin loader activity. Involved in several processes, including chromosome organization; double-strand break repair involved in meiotic recombination; and regulation of cell cycle process. Located in chromosome and nucleus. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 1. Is an ortholog of human NIPBL (NIPBL cohesin loading factor).
Enriched in somatic gonad precursor based on RNA-seq studies. Is affected by pqn-59 based on proteomic studies. Is affected by Rifampin based on RNA-seq studies.