- nos-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable mRNA binding activity and zinc ion binding activity. Involved in oogenesis and regulation of cell cycle. Located in cytoplasm. Expressed in P0; P4; Z2; and Z3. Human ortholog(s) of this gene implicated in spermatogenic failure 12. Is an ortholog of human NANOS1 (nanos C2HC-type zinc finger 1); NANOS2 (nanos C2HC-type zinc finger 2); and NANOS3 (nanos C2HC-type zinc finger 3).
- out [Search on AGR]
Drosophila melanogaster outsiders (out) encodes a monocarboxylate transporter involved in programmed cell death of primordial germ cell/pole cells.
- Pum3 [Search on AGR]
Mus musculus PHENOTYPE: Mice hemizygous for an inducible knockdown transgenic allele display loss of primordial germ cells. [provided by MGI curators]
- Prdm1 [Search on AGR]
Mus musculus PHENOTYPE: Homozygous null mice display embryonic lethality and impaired primordial germ cell development, while heterozygotes display a decreased numbers of primordial germ cells but normal migration. Conditional mutants display impaired plasma cell and pre-plasmamemory B cell development. [provided by MGI curators]
- puf-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable mRNA 3'-UTR binding activity. Involved in germ cell development and negative regulation of cell population proliferation. Predicted to be located in cytoplasm and nucleus.
- Larp7 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a null mutation display complete perinatal lethality and a decrease in primordial germ cell number and proliferation. [provided by MGI curators]
- Faap100 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a null allele exhibit primordial germ cell loss at E9.5 associated with increased DNA damage and apoptosis. [provided by MGI curators]
- Prdm14 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a knockout allele exhibit decreased primordial germ cell numbers, absent germ cells, and sterility in both males and females. [provided by MGI curators]
- mamo [Search on AGR]
Drosophila melanogaster maternal gene required for meiosis (mamo) encodes a zinc finger C2H2 transcription factor enriched in embryonic primordial germ cells. It is required for functional gamete production.