- ptp-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable non-membrane spanning protein tyrosine phosphatase activity and phosphotyrosine residue binding activity. Involved in several processes, including nematode larval development; positive regulation of signal transduction; and positive regulation of vulval development. Located in cytoplasmic vesicle. Expressed in body wall musculature; head ganglion; pharynx; spermatheca; and tail. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 1; Noonan syndrome with multiple lentigines 1; and anogenital venereal wart. Is an ortholog of human PTPN6 (protein tyrosine phosphatase non-receptor type 6).
- ptp-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable protein tyrosine phosphatase activity. Located in sarcoplasmic reticulum. Expressed in muscle cell; nerve ring; neurons; pharyngeal nervous system; and ventral nerve cord. Is an ortholog of human PTPN3 (protein tyrosine phosphatase non-receptor type 3) and PTPN4 (protein tyrosine phosphatase non-receptor type 4).
- ptp-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables protein tyrosine phosphatase activity. Involved in several processes, including embryonic morphogenesis; nervous system development; and neuroblast migration. Located in adherens junction and synapse. Expressed in embryonic cell; hypodermis; and nervous system. Human ortholog(s) of this gene implicated in hyperinsulinism and obesity. Is an ortholog of human PTPRD (protein tyrosine phosphatase receptor type D) and PTPRF (protein tyrosine phosphatase receptor type F).
- vab-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables ephrin receptor binding activity. Involved in ephrin receptor signaling pathway and epidermis morphogenesis. Located in axon and external side of plasma membrane. Expressed in several structures, including anterior ganglion; neuroblasts; neurons; somatic nervous system; and ventral ganglion (post). Human ortholog(s) of this gene implicated in craniofrontonasal syndrome; dysostosis; and stomach cancer. Is an ortholog of human EFNB1 (ephrin B1).
- dep-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables phosphatase activity. Involved in positive regulation of vulval development and vulval cell fate specification. Predicted to be located in membrane. Expressed in several structures, including P5.paa; P5.pap; P5.ppa; P5.ppp; and P7.paa. Human ortholog(s) of this gene implicated in several diseases, including breast angiosarcoma; carcinoma (multiple); and central nervous system cancer (multiple). Is an ortholog of human PTPRB (protein tyrosine phosphatase receptor type B).