Predicted to enable protein tyrosine kinase activity. Involved in embryo development; negative regulation of epidermal growth factor receptor signaling pathway; and negative regulation of vulval development.
Is predicted to encode a protein with the following domains: ATPase, nucleotide binding domain; ROK family; Glycosyl hydrolase family 32, C-terminal; Glycosyl hydrolase, five-bladed beta-propellor domain superfamily; Glycosyl hydrolases family 32 C terminal; and Concanavalin A-like lectin/glucanase domain superfamily.
Rho kinase (Rok) encodes a kinase that, when activated by the GTP form of the product of Rho1, phosphorylates and modulates cytoskeletal proteins, particularly myosin II. Dynamic regulation of this kinase in subcellular locales influences cell polarization, movement, and shape during interphase and mitosis.
combover (cmb) encodes an in vitro substrate of the product of Rok, that physically interacts with the planar cell polarity (PCP) effector encoded by mwh, contributing to PCP during wing hair formation. Independent of PCP, cmb is required for spermiogenesis, during which it interacts with Rsph3.