Enables JUN kinase kinase activity. Involved in hyperosmotic response and locomotion. Located in axon; cytoplasm; and neuronal cell body. Expressed in neurons. Human ortholog(s) of this gene implicated in colon adenocarcinoma; lung adenocarcinoma; and prostate carcinoma in situ. Is an ortholog of human MAP2K7 (mitogen-activated protein kinase kinase 7).
Is affected by several genes including daf-2; sek-1; and sma-2 based on RNA-seq and microarray studies. Is affected by Doxycycline based on RNA-seq studies.
Is affected by several genes including eat-2; clk-1; and sek-1 based on microarray and RNA-seq studies. Is affected by fluoranthene based on microarray studies.
Is affected by several genes including daf-2; sek-1; and unc-30 based on RNA-seq and microarray studies. Is affected by Alovudine and atracurium based on RNA-seq studies.