Predicted to enable minus-end-directed microtubule motor activity. Involved in several processes, including cellular localization; neuron remodeling; and regulation of cellular localization. Located in several cellular components, including kinetochore; nuclear envelope; and spindle pole. Expressed in germ cell; head; somatic cell; and tail. Used to study epilepsy and lissencephaly. Human ortholog(s) of this gene implicated in Alzheimer's disease; Charcot-Marie-Tooth disease axonal type 2O; autosomal dominant intellectual developmental disorder 13; and spinal muscular atrophy with lower extremity predominant 1. Is an ortholog of human DYNC1H1 (dynein cytoplasmic 1 heavy chain 1).
Enables identical protein binding activity. Involved in centrosome cycle; positive regulation of mitotic cell cycle, embryonic; and protein localization to organelle. Located in centrosome and cytoplasm.
Involved in several processes, including homologous chromosome segregation; microtubule cytoskeleton organization; and vulval development. Located in mitochondrion.
Enables protein kinase binding activity. Involved in several processes, including centriole replication; embryo development; and vulval development. Located in centriole; cytoplasm; and pericentriolar material. Expressed in intestinal cell.
Enables microtubule binding activity. Involved in several processes, including ciliary body morphogenesis; gonad development; and microtubule bundle formation involved in mitotic spindle midzone assembly. Located in microtubule; mitotic spindle midzone; and nucleus. Is an ortholog of human PRC1 (protein regulator of cytokinesis 1).
Predicted to enable olfactory receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception. Predicted to be located in membrane.
Is affected by Cbr-spr-4 based on RNA-seq studies. Is an ortholog of C. elegans spd-5. In C. elegans, spd-5 is involved in centrosome cycle; positive regulation of mitotic cell cycle, embryonic; and protein localization to organelle.
Is an ortholog of C. elegans spd-3. In C. elegans, spd-3 is involved in several processes, including homologous chromosome segregation; microtubule cytoskeleton organization; and vulval development.
Is an ortholog of C. elegans spd-3. In C. elegans, spd-3 is involved in several processes, including homologous chromosome segregation; microtubule cytoskeleton organization; and vulval development.
Is an ortholog of C. elegans spd-3. In C. elegans, spd-3 is involved in several processes, including homologous chromosome segregation; microtubule cytoskeleton organization; and vulval development.