let-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans An extracellular matrix structural constituent conferring tensile strength. Involved in several processes, including embryo development; gonad morphogenesis; and regulation of distal tip cell migration. Located in basement membrane. Part of collagen type IV trimer. Expressed in several structures, including coelomocyte; egg-laying apparatus; rectal muscle; spermatheca; and tail. Human ortholog(s) of this gene implicated in several diseases, including X-linked Alport syndrome; X-linked deafness 6; and artery disease (multiple). Is an ortholog of human COL4A1 (collagen type IV alpha 1 chain); COL4A5 (collagen type IV alpha 5 chain); and COL4A6 (collagen type IV alpha 6 chain).
sup-26 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables mRNA 3'-UTR binding activity. Involved in negative regulation of translation. Located in cytoplasm. Expressed in several structures, including gonad. Is an ortholog of human RBMS1 (RNA binding motif single stranded interacting protein 1); RBMS2 (RNA binding motif single stranded interacting protein 2); and RBMS3 (RNA binding motif single stranded interacting protein 3).
sup-12 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables pre-mRNA intronic binding activity and single-stranded RNA binding activity. Involved in several processes, including alternative mRNA splicing, via spliceosome; regulation of actin cytoskeleton organization; and regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. Part of ribonucleoprotein complex. Is an ortholog of human RBM24 (RNA binding motif protein 24) and RBM38 (RNA binding motif protein 38).
sup-9 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Involved in regulation of muscle contraction. Located in muscle cell projection membrane and striated muscle dense body. Expressed in body wall musculature; muscle cell; and neurons. Human ortholog(s) of this gene implicated in Birk-Barel syndrome and primary pulmonary hypertension. Is an ortholog of human KCNK3 (potassium two pore domain channel subfamily K member 3) and KCNK9 (potassium two pore domain channel subfamily K member 9).
Sdad1 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for ENU-induced alleles Dmp1<sup>
m1Btlr</sup>, Sdad1<sup>
m1Btlr</sup>, and Ptpn11<sup>
m1Btlr</sup> exhibit decreased bone mineral density and short tibia. [provided by MGI curators]
Rsxr [Search on AGR]
Mus musculus PHENOTYPE: The Rsxr<sup>129S1/Sv</sup> allele confers resistance to sex reversal in genetic XY males from consomic line B6.129-Chr Y<sup>POS</sup>. The Rsxr<sup>C57BL/6J</sup> allele confers sex reversal in genetic XY males from consomic line C57BL/6J-Hba<sup>th-J</sup> Chr Y<sup>POS</sup>. [provided by MGI curators]
ift-20 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in centrosome localization; intraciliary transport; and protein localization to cilium. Located in dendrite; neuronal cell body; and non-motile cilium. Expressed in ciliated neurons; sensory neurons; and tail. Is an ortholog of human IFT20 (intraflagellar transport 20).
sup-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable metalloendopeptidase activity. Involved in several processes, including nematode male tail tip morphogenesis; positive regulation of transforming growth factor beta receptor signaling pathway; and vulval development. Located in cytoplasmic vesicle membrane and plasma membrane. Expressed in M lineage cell; hypodermis; intestinal cell; spermatheca; and vulva. Human ortholog(s) of this gene implicated in Alzheimer's disease 18; colorectal cancer; and reticulate acropigmentation of Kitamura. Is an ortholog of human ADAM10 (ADAM metallopeptidase domain 10).
Btg2 [Search on AGR]
Mus musculus PHENOTYPE: Homozygous null Btg2<sup>
tm1Wbh</sup> mice do not exhibit an overt phenotype. Homozygous null Btg2<sup>
tm1Spo</sup> mice exhibit posterior homeotic transformations of the axial vertebrae. [provided by MGI curators]
Fxyd4 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a targeted null mutation are viable and fertile but exhibit a significant increase in urine volume (and water intake) under Na<sup>+</sup> deprivation and K<sup>+</sup> loading, as well as lethality after a combination of high-K<sup>+</sup> intake and furosemide injection. [provided by MGI curators]
Batf3 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a null mutation lack CD8alpha<sup>+</sup> dendritic cells, have dysfunctional cross-presentation of antigens, and generate lower numbers of memory CD8<sup>+</sup> T cells in response to infection. [provided by MGI curators]
Mir708 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a null allele suppresses Apc<sup>Min</sup>-induced tumorigenesis. [provided by MGI curators]
acs-20 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable long-chain fatty acid transporter activity and long-chain fatty acid-CoA ligase activity. Predicted to be involved in triglyceride homeostasis. Located in intracellular membrane-bounded organelle. Expressed in anal depressor muscle; anal sphincter muscle; head;
hyp7 syncytium; and seam cell. Human ortholog(s) of this gene implicated in obesity. Is an ortholog of human SLC27A1 (solute carrier family 27 member 1) and SLC27A4 (solute carrier family 27 member 4).
Jph4 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a knock-out allele exhibit a reduction in endoplasmic reticulum Ca<sup>2+</sup> content, store-operated Ca<sup>2+</sup> entry and cytokine production in T cells and decreased ERK activation after TCR stimulation. [provided by MGI curators]
H2-T23 [Search on AGR]
Mus musculus PHENOTYPE: CD4<sup>+</sup> T cells from mice with a homozygous null mutation have enhanced responses after infection or immunization, are resistant to suppressor activity mediated by a subset of CD8<sup>+</sup> T cells, but are more susceptible to NK cell lysis. [provided by MGI curators]
szy-20 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA binding activity. Involved in several processes, including negative regulation of protein localization to centrosome; positive regulation of fertilization; and regulation of cell cycle. Located in centrosome; cytoplasm; and nucleolus.
unc-93 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables potassium channel regulator activity. Involved in regulation of muscle contraction and regulation of potassium ion transport. Located in plasma membrane and striated muscle dense body. Expressed in SIA; body wall musculature; and non-striated muscle. Is an ortholog of human UNC93A (
unc-93 homolog A).
pitr-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable inorganic phosphate transmembrane transporter activity. Predicted to be involved in phosphate ion transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in basal ganglia calcification. Is an ortholog of human SLC20A1 (solute carrier family 20 member 1) and SLC20A2 (solute carrier family 20 member 2).
pitr-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable inorganic phosphate transmembrane transporter activity. Predicted to be involved in phosphate ion transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in basal ganglia calcification. Is an ortholog of human SLC20A1 (solute carrier family 20 member 1) and SLC20A2 (solute carrier family 20 member 2).
pitr-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable inorganic phosphate transmembrane transporter activity. Predicted to be involved in phosphate ion transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in basal ganglia calcification. Is an ortholog of human SLC20A1 (solute carrier family 20 member 1) and SLC20A2 (solute carrier family 20 member 2).
pitr-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable inorganic phosphate transmembrane transporter activity. Predicted to be involved in phosphate ion transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in basal ganglia calcification. Is an ortholog of human SLC20A1 (solute carrier family 20 member 1) and SLC20A2 (solute carrier family 20 member 2).
pitr-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable inorganic phosphate transmembrane transporter activity. Predicted to be involved in phosphate ion transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in basal ganglia calcification. Is an ortholog of human SLC20A1 (solute carrier family 20 member 1) and SLC20A2 (solute carrier family 20 member 2).
ceh-40 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in animal organ development; neuron development; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in dopaminergic neurons.
evl-20 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable GTP binding activity. Involved in several processes, including cortical microtubule organization; female genitalia development; and mitotic cytokinesis. Located in cytoplasm; microtubule cytoskeleton; and plasma membrane. Expressed in several structures, including P3.p hermaphrodite; hermaphrodite gonad;
hyp12; proctodeum; and vulval cell. Is an ortholog of human ARL2 (ADP ribosylation factor like GTPase 2).
ceh-20 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables cis-regulatory region sequence-specific DNA binding activity and transcription coactivator binding activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell differentiation; positive regulation of mesodermal cell fate specification; and regulation of asymmetric cell division. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Expressed in several structures, including P1.p; P2.p; neurons; seam cell; and somatic nervous system. Human ortholog(s) of this gene implicated in congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay; esophagus squamous cell carcinoma; and glaucoma. Is an ortholog of human PBX4 (PBX homeobox 4).
Hnrnpll [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a point mutation in a RNA recognition motif of the gene product have defects in the generation of alternative transcripts normally found in memory T cells. Total CD4<sup>+</sup> T cell counts are lower, with a reduction of nave CD44<sup>lo</sup> T cells occurring as mice age. [provided by MGI curators]
sup-46 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable mRNA binding activity. Predicted to be located in cytoplasm and nucleus. Expressed in germ cell and somatic cell. Human ortholog(s) of this gene implicated in colorectal carcinoma and leiomyoma. Is an ortholog of human HNRNPM (heterogeneous nuclear ribonucleoprotein M) and MYEF2 (myelin expression factor 2).
Ebag9 [Search on AGR]
Mus musculus PHENOTYPE: Homozygous null mice have decreased susceptibility to bacterial infections and have CD8<sup>+</sup> T cells with enhanced cytolytic activity. [provided by MGI curators]
fry [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for an ENU induced allele that segregates with Kl<sup>
m1Btlr</sup> exhibit short tibia, femur, and pelvis. [provided by MGI curators]
Repin1 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a knock-out allele improves in insulin sensitivity and glucose metabolism in Lepr<sup>db</sup> homozygotes. [provided by MGI curators]
Clec9a [Search on AGR]
Mus musculus PHENOTYPE: Homozygous null mice have CD8alpha<sup>+</sup> dendritic cells that are defective in cross-presentation of dead-cell associated antigens. [provided by MGI curators]
mab-20 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables semaphorin receptor binding activity. Involved in several processes, including anatomical structure morphogenesis; axonal fasciculation; and regulation of locomotion. Located in cell surface. Expressed in several structures, including linker cell; ray neurons; ray precursor cell; somatic nervous system; and vulval cell. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Is an ortholog of human SEMA3B (semaphorin 3B) and SEMA3C (semaphorin 3C).
Y41C4A.21 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Is affected by several genes including
daf-2;
aak-2; and
unc-30 based on RNA-seq and microarray studies. Is affected by Doxycycline; Tamoxifen; and paraquat based on RNA-seq studies. Is predicted to encode a protein with the following domains: Protein SUP-1-like and Protein of unknown function (DUF2650).
Ankrd16 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a knock-out allele exhibit no obvious pathologies. The variant from CAST/Ei or CASA/RkJ suppresses the Aars<sup>sti</sup> phenotype. [provided by MGI curators]
gly-20 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity. Involved in protein N-linked glycosylation. Predicted to be located in Golgi membrane. Used to study carbohydrate metabolic disorder. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIa. Is an ortholog of human MGAT2 (alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase).
pitr-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable inorganic phosphate transmembrane transporter activity. Predicted to be involved in phosphate ion transmembrane transport. Predicted to be located in membrane. Expressed in several structures, including body wall musculature; hermaphrodite gonad; intestine; nerve ring; and pharynx. Human ortholog(s) of this gene implicated in basal ganglia calcification. Is an ortholog of human SLC20A1 (solute carrier family 20 member 1) and SLC20A2 (solute carrier family 20 member 2).
skr-20 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable cullin family protein binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and nucleus. Is an ortholog of human SKP1 (S-phase kinase associated protein 1).
Rfx5 [Search on AGR]
Mus musculus PHENOTYPE: Homozygous null mice have absent or decreased expression of MHC-II complexes on antigen presenting cells, which leads to reduced numbers of CD4<sup>+</sup> thymocytes and T cells. [provided by MGI curators]
rga-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable GTPase activator activity. Predicted to be involved in signal transduction. Expressed in rectum; socket cell; uterus; and vulva. Is an ortholog of human ARHGAP20 (Rho GTPase activating protein 20).
his-20 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Predicted to be part of nucleosome. Is an ortholog of several human genes including H2BC3 (H2B clustered histone 3); H2BC5 (H2B clustered histone 5); and H2BC8 (H2B clustered histone 8).
taf-12 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA binding activity and TBP-class protein binding activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly. Located in nucleus. Is an ortholog of human TAF12 (TATA-box binding protein associated factor 12).
Asic1 [Search on AGR]
Mus musculus PHENOTYPE: Homozygous mutation of this gene results in absence of H<sup>+</sup>-gated currents in hippocampal neurons, impaired long term potentiation, reduced excitatory postsynaptic potentials, and defective spatial learning and eye blink conditioning. [provided by MGI curators]
Mrln [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a knock-out allele show improved exercise performance and enhanced Ca<sup>2+</sup> handling in skeletal muscle. Mice homozygous for another knock-out exhibit reduced myofiber numbers and muscle regeneration. [provided by MGI curators]
egl-23 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be located in membrane.
fat-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable oxidoreductase activity. Involved in positive regulation of locomotion and unsaturated fatty acid biosynthetic process. Predicted to be located in membrane. Expressed in intestine; nerve ring; and touch receptor neurons. Used to study alcohol use disorder.
psa-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables transcription coactivator binding activity. Involved in regulation of asymmetric cell division. Located in nucleus. Expressed in several structures, including TL.aa; TL.pa; TR.aa; TR.pa; and hypodermal cell.
Cjp-sup-9 [Browse genome (BioProject PRJNA12591)] [Search on AGR]
Caenorhabditis japonica Predicted to enable potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in membrane. Is an ortholog of C. elegans
sup-9. In C. elegans,
sup-9 is involved in regulation of muscle contraction.
Pacc1 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a knock-out allele show absence of proton-activated Cl<sup>-</sup> (PAC) currents and decreased sensitivity to acid-induced cell death in primary cortical neurons, and decreased susceptibility to ischemic brain injury. [provided by MGI curators]
Zfp82 [Search on AGR]
Mus musculus PHENOTYPE: Mice heterozygous for a null allele exhibit increased colon tumor in Apc<sup>Min</sup>. Mice homozygous for a conditional allele activated in the colon exhibit increased sensitivity to AOM/DSS-induced tumors. [provided by MGI curators]
CBN22872 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Predicted to enable potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in membrane. Is an ortholog of C. elegans
sup-9. In C. elegans,
sup-9 is involved in regulation of muscle contraction.
Csl [Search on AGR]
Mus musculus PHENOTYPE: Male mice homozygous for a knock-out allele are initially fertile but show an age-dependent decline in fertility and a delay in the first spike of Ca<sup>2+</sup> oscillation during egg activation. [provided by MGI curators]
Bma-sup-12 [Browse genome (BioProject PRJNA10729)] [Search on AGR]
Brugia malayi Predicted to enable RNA binding activity. Is an ortholog of C. elegans
sup-12. In C. elegans,
sup-12 is involved in several processes, including alternative mRNA splicing, via spliceosome; regulation of actin cytoskeleton organization; and regulation of alternative mRNA splicing, via spliceosome.
Bma-sup-17 [Browse genome (BioProject PRJNA10729)] [Search on AGR]
Brugia malayi Predicted to enable metallopeptidase activity. Is an ortholog of C. elegans
sup-17. In C. elegans,
sup-17 is involved in several processes, including nematode male tail tip morphogenesis; positive regulation of transforming growth factor beta receptor signaling pathway; and vulval development.
Cre-sup-12 [Browse genome (BioProject PRJNA577507)] [Search on AGR]
Caenorhabditis remanei Predicted to enable RNA binding activity. Is an ortholog of C. elegans
sup-12. In C. elegans,
sup-12 is involved in several processes, including alternative mRNA splicing, via spliceosome; regulation of actin cytoskeleton organization; and regulation of alternative mRNA splicing, via spliceosome.
Cre-sup-17 [Browse genome (BioProject PRJNA577507)] [Search on AGR]
Caenorhabditis remanei Predicted to enable metallopeptidase activity. Is an ortholog of C. elegans
sup-17. In C. elegans,
sup-17 is involved in several processes, including nematode male tail tip morphogenesis; positive regulation of transforming growth factor beta receptor signaling pathway; and vulval development.
Hmt4-20 [Search on AGR]
Drosophila melanogaster Histone methyltransferase 4-20 (Hmt4-20) encodes a di- and trimethyltransferase, acting on the lysine 20 residue of monomethylated Histone H4.
Cbr-sup-12 [Browse genome (BioProject PRJNA10731)] [Search on AGR]
Caenorhabditis briggsae Predicted to enable RNA binding activity. Is an ortholog of C. elegans
sup-12. In C. elegans,
sup-12 is involved in several processes, including alternative mRNA splicing, via spliceosome; regulation of actin cytoskeleton organization; and regulation of alternative mRNA splicing, via spliceosome.
Cbr-sup-17 [Browse genome (BioProject PRJNA10731)] [Search on AGR]
Caenorhabditis briggsae Predicted to enable metallopeptidase activity. Is an ortholog of C. elegans
sup-17. In C. elegans,
sup-17 is involved in several processes, including nematode male tail tip morphogenesis; positive regulation of transforming growth factor beta receptor signaling pathway; and vulval development.
SRAE_1000157400 [Browse genome (BioProject PRJEB125)] [Search on AGR]
Strongyloides ratti Predicted to enable RNA binding activity. Is an ortholog of C. elegans
sup-12. In C. elegans,
sup-12 is involved in several processes, including alternative mRNA splicing, via spliceosome; regulation of actin cytoskeleton organization; and regulation of alternative mRNA splicing, via spliceosome.
Cbn-sup-9 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Predicted to enable potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in membrane. Is an ortholog of C. elegans
sup-9. In C. elegans,
sup-9 is involved in regulation of muscle contraction.
Cbr-sup-9 [Browse genome (BioProject PRJNA10731)] [Search on AGR]
Caenorhabditis briggsae Predicted to enable potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in membrane. Is an ortholog of C. elegans
sup-9. In C. elegans,
sup-9 is involved in regulation of muscle contraction.
Cbn-sup-12 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Predicted to enable RNA binding activity. Is an ortholog of C. elegans
sup-12. In C. elegans,
sup-12 is involved in several processes, including alternative mRNA splicing, via spliceosome; regulation of actin cytoskeleton organization; and regulation of alternative mRNA splicing, via spliceosome.
Cjp-sup-12 [Browse genome (BioProject PRJNA12591)] [Search on AGR]
Caenorhabditis japonica Predicted to enable RNA binding activity. Is an ortholog of C. elegans
sup-12. In C. elegans,
sup-12 is involved in several processes, including alternative mRNA splicing, via spliceosome; regulation of actin cytoskeleton organization; and regulation of alternative mRNA splicing, via spliceosome.
Ppa-sup-12 [Browse genome (BioProject PRJNA12644)] [Search on AGR]
Pristionchus pacificus Predicted to enable RNA binding activity. Is an ortholog of C. elegans
sup-12. In C. elegans,
sup-12 is involved in several processes, including alternative mRNA splicing, via spliceosome; regulation of actin cytoskeleton organization; and regulation of alternative mRNA splicing, via spliceosome.
Ppa-sup-17 [Browse genome (BioProject PRJNA12644)] [Search on AGR]
Pristionchus pacificus Predicted to enable metallopeptidase activity. Is an ortholog of C. elegans
sup-17. In C. elegans,
sup-17 is involved in several processes, including nematode male tail tip morphogenesis; positive regulation of transforming growth factor beta receptor signaling pathway; and vulval development.
SRAE_1000290600 [Browse genome (BioProject PRJEB125)] [Search on AGR]
Strongyloides ratti Predicted to enable metallopeptidase activity. Is an ortholog of C. elegans
sup-17. In C. elegans,
sup-17 is involved in several processes, including nematode male tail tip morphogenesis; positive regulation of transforming growth factor beta receptor signaling pathway; and vulval development.
TMUE_1000002988 [Browse genome (BioProject PRJEB126)] [Search on AGR]
Trichuris muris Predicted to enable metallopeptidase activity. Is an ortholog of C. elegans
sup-17. In C. elegans,
sup-17 is involved in several processes, including nematode male tail tip morphogenesis; positive regulation of transforming growth factor beta receptor signaling pathway; and vulval development.
Cbn-sup-17.1 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Predicted to enable metallopeptidase activity. Is an ortholog of C. elegans
sup-17. In C. elegans,
sup-17 is involved in several processes, including nematode male tail tip morphogenesis; positive regulation of transforming growth factor beta receptor signaling pathway; and vulval development.
Cjp-sup-17 [Browse genome (BioProject PRJNA12591)] [Search on AGR]
Caenorhabditis japonica Predicted to enable metallopeptidase activity. Is an ortholog of C. elegans
sup-17. In C. elegans,
sup-17 is involved in several processes, including nematode male tail tip morphogenesis; positive regulation of transforming growth factor beta receptor signaling pathway; and vulval development.
CtsB [Search on AGR]
Mus musculus PHENOTYPE: Homozygotes for targeted null mutations are born normal without gross abnormalities. Homozygous mutant has resistance to induced pancreatitis. In combination with Ctsl<sup>
tm1Cptr</sup>, double homozygous mutant shows postnatal lethality due to wide neuronal degeneration in brain. [provided by MGI curators]
TMUE_3000011175 [Browse genome (BioProject PRJEB126)] [Search on AGR]
Trichuris muris Predicted to enable RNA binding activity. Is an ortholog of C. elegans
sup-12. In C. elegans,
sup-12 is involved in several processes, including alternative mRNA splicing, via spliceosome; regulation of actin cytoskeleton organization; and regulation of alternative mRNA splicing, via spliceosome.
TMUE_3000011269 [Browse genome (BioProject PRJEB126)] [Search on AGR]
Trichuris muris Predicted to enable RNA binding activity. Is an ortholog of C. elegans
sup-12. In C. elegans,
sup-12 is involved in several processes, including alternative mRNA splicing, via spliceosome; regulation of actin cytoskeleton organization; and regulation of alternative mRNA splicing, via spliceosome.
Cbn-sup-17.2 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Predicted to enable metallopeptidase activity. Is an ortholog of C. elegans
sup-17. In C. elegans,
sup-17 is involved in several processes, including nematode male tail tip morphogenesis; positive regulation of transforming growth factor beta receptor signaling pathway; and vulval development.
Ovo-sup-12 [Browse genome (BioProject PRJEB513)] [Search on AGR]
Onchocerca volvulus Predicted to enable RNA binding activity. Is an ortholog of C. elegans
sup-12. In C. elegans,
sup-12 is involved in several processes, including alternative mRNA splicing, via spliceosome; regulation of actin cytoskeleton organization; and regulation of alternative mRNA splicing, via spliceosome.
Ovo-sup-17 [Browse genome (BioProject PRJEB513)] [Search on AGR]
Onchocerca volvulus Predicted to enable metallopeptidase activity. Is an ortholog of C. elegans
sup-17. In C. elegans,
sup-17 is involved in several processes, including nematode male tail tip morphogenesis; positive regulation of transforming growth factor beta receptor signaling pathway; and vulval development.
Mir10a [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a targeted deletion are viable with no observed pathologies. Mice homozygous for a knock-out allele exhibit increased frequency with of high-grade dysplasia and higher incidence of tubule-villous adenomas in Apc<sup>min</sup> heterozygotes. [provided by MGI curators]
cfap-20 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in cilium assembly; positive regulation of feeding behavior; and regulation of cell motility. Predicted to be located in microtubule cytoskeleton and motile cilium. Is an ortholog of human CFAP20 (cilia and flagella associated protein 20).
H2-T18 [Search on AGR]
Mus musculus PHENOTYPE: This locus contains the coding member of a gene pair encoding the thymic leukemia antigen or TL antigen in "d haplotype" mice such as BALB/c. The other member of this gene pair, H2-T3<sup>d</sup>, is a pseudogene. [provided by MGI curators]
Tmtc4 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a knock-out allele exhibit early-onset hearing loss associated with progressive degeneration of cochlear outer hair cells, inner hair cells and supporting cells, increased endoplasmic reticulum (ER) stress, and altered ER Ca<sup>2+</sup> dynamics. [provided by MGI curators]
usp-33 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of apoptotic process. Predicted to be located in cytosol and nucleus. Is an ortholog of human USP20 (ubiquitin specific peptidase 20) and USP33 (ubiquitin specific peptidase 33).
set-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable histone H4K20me methyltransferase activity. Involved in determination of adult lifespan. Predicted to be located in chromosome and nucleus. Expressed in several structures, including hypodermis and muscle cell. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 51. Is an ortholog of human KMT5B (lysine methyltransferase 5B) and KMT5C (lysine methyltransferase 5C).
Y116A8C.20 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable mRNA 3'-UTR binding activity. Predicted to be located in cytosol. Expressed in dorsal nerve cord and ventral nerve cord. Human ortholog(s) of this gene implicated in breast cancer. Is an ortholog of human ZFP36 (ZFP36 ring finger protein); ZFP36L1 (ZFP36 ring finger protein like 1); and ZFP36L2 (ZFP36 ring finger protein like 2).
bmy-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables identical protein binding activity. Predicted to be involved in protein folding. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 20. Is an ortholog of human MESD (mesoderm development LRP chaperone).
klp-20 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables microtubule motor activity. Involved in microtubule-based movement. Part of axonemal heterotrimeric kinesin-II complex. Expressed in ciliated neurons; distal tip cell; and head. Human ortholog(s) of this gene implicated in silicosis. Is an ortholog of human KIF3A (kinesin family member 3A).
snx-14 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in autophagosome maturation. Predicted to be located in late endosome. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 20. Is an ortholog of human SNX14 (sorting nexin 14).
natb-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable peptide alpha-N-acetyltransferase activity. Predicted to be part of NatB complex. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 73. Is an ortholog of human NAA20 (N-alpha-acetyltransferase 20, NatB catalytic subunit).
Bst1 [Search on AGR]
Mus musculus PHENOTYPE: Homozygous null mice show delayed peritoneal B-1 cell development and a rise in CD38<sup>low/-</sup> B-lineage cells in bone marrow and spleen. The systemic thymus-independent-2 antigen-induced IgG3 and mucosal thymus-dependent antigen-elicited IgA responses are selectively impaired. [provided by MGI curators]
mt-Nd2 [Search on AGR]
Mus musculus PHENOTYPE: A single point mutation specific to the ALR/Lt strain confers increased resistance to autoimmune diabetes. A conplastic strain generated with ALR nuclear DNA and NOD mtDNA exhibits increased mitochondrial ROS production relative to either parental strain, NOD.mt<sup>ALR</sup> or C57BL/6 controls. [provided by MGI curators]
tbc-9 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable GTPase activator activity. Human ortholog(s) of this gene implicated in nephrotic syndrome type 20. Is an ortholog of several human genes including TBC1D8 (TBC1 domain family member 8); TBC1D9 (TBC1 domain family member 9); and TBC1D9B (TBC1 domain family member 9B).
mdt-20 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable transcription coactivator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus and protein-containing complex. Predicted to be part of mediator complex. Is an ortholog of human MED20 (mediator complex subunit 20).
btbd-10 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in positive regulation of phosphorylation. Predicted to be located in cytoplasm. Expressed in hypodermal cell; intestine; pharyngeal neurons; and pharyngeal-intestinal valve. Is an ortholog of human BTBD10 (BTB domain containing 10) and KCTD20 (potassium channel tetramerization domain containing 20).
Scnm1 [Search on AGR]
Mus musculus PHENOTYPE: The Scnm1 locus influences the severity of the Scn8a<sup>med-J</sup> phenotype. Mice carrying the recesive susceptibility allele of the modifier are paralyzed and do not survive beyond 1 month. Mice carryimg the resistant allele display progressive dystonia with ataxia and live more than 1.5 years. [provided by MGI curators]
spp-20 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in dopaminergic neurons and sensory neurons based on tiling array and RNA-seq studies. Is affected by several genes including
daf-2;
age-1; and
let-60 based on microarray; tiling array; and RNA-seq studies. Is affected by seventeen chemicals including diallyl trisulfide; Tunicamycin; and D-glucose based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: Saposin-like and Saposin B type domain.
fat-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables stearoyl-CoA 9-desaturase activity. Involved in unsaturated fatty acid biosynthetic process. Predicted to be located in membrane. Expressed in nerve ring and touch receptor neurons. Used to study alcohol use disorder. Is an ortholog of human FADS1 (fatty acid desaturase 1).
TMUE_3000013307 [Browse genome (BioProject PRJEB126)] [Search on AGR]
Trichuris muris Predicted to enable potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in membrane. Is an ortholog of C. elegans
sup-9 and B0310.1 and members of the C. elegans twk gene class including
twk-43. In C. elegans,
sup-9 is involved in regulation of muscle contraction.
TMUE_3000011598 [Browse genome (BioProject PRJEB126)] [Search on AGR]
Trichuris muris Predicted to enable potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in membrane. Is an ortholog of C. elegans
sup-9 and B0310.1 and members of the C. elegans twk gene class including
twk-43. In C. elegans,
sup-9 is involved in regulation of muscle contraction.
rpl-20 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in ribosome. Predicted to be part of cytosolic large ribosomal subunit. Is an ortholog of human RPL18A (ribosomal protein L18a).
mel-46 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA binding activity and RNA helicase activity. Predicted to be involved in spliceosomal snRNP assembly. Predicted to be located in P granule. Predicted to be part of SMN complex. Expressed in germ line. Is an ortholog of human DDX20 (DEAD-box helicase 20).
rps-20 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in ribosome. Predicted to be part of cytosolic small ribosomal subunit. Is an ortholog of human RPS20 (ribosomal protein S20).
tbc-20 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable GTPase activator activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Warburg micro syndrome 4. Is an ortholog of human TBC1D20 (TBC1 domain family member 20).
dyf-18 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in phosphorylation and regulation of cell cycle. Predicted to be located in nucleus. Expressed in amphid neurons; head; inner labial neurons; outer labial neurons; and phasmid neurons. Is an ortholog of human CDK20 (cyclin dependent kinase 20).
acr-20 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in excitatory postsynaptic potential and monoatomic ion transmembrane transport. Predicted to be located in neuron projection and synapse.
Y73B6BL.14 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATP binding activity; DNA binding activity; and DNA ligase (ATP) activity. Predicted to be involved in DNA recombination; DNA repair; and DNA replication. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 20 and pancreatic cancer. Is an ortholog of human LIG3 (DNA ligase 3).
K07C5.3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA ligase (ATP) activity. Predicted to be involved in DNA ligation and lagging strand elongation. Predicted to be located in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 20 and pancreatic cancer. Is an ortholog of human LIG3 (DNA ligase 3).
ND-20 [Search on AGR]
Drosophila melanogaster NADH dehydrogenase (ubiquinone) 20 kDa subunit (ND-20) encodes a component of the mitochondrial electron transport chain and is involved in determination of life span.
plx-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables semaphorin receptor activity. Involved in several processes, including axonal fasciculation; nematode male tail tip morphogenesis; and regulation of axon guidance. Located in cell leading edge and cell surface. Expressed in several structures, including P3/4L; P9/10L; P9/10R; neuroblasts; and ray structural cell.
ZK353.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in several structures, including ABplppppaa; MSpppaaa; anterior arcade cell; head mesodermal cell; and rectal gland cell based on tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including
daf-2;
elt-2; and
aak-2 based on tiling array; microarray; and RNA-seq studies. Is affected by nine chemicals including multi-walled carbon nanotube; Psoralens; and allantoin based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: Protein SUP-1-like and Protein of unknown function (DUF2650).
gcy-20 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable adenylate cyclase activity; guanylate cyclase activity; and peptide receptor activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Predicted to be located in plasma membrane. Expressed in ASEL; AWCL; AWCR; excretory canal; and excretory gland cell.
wdr-20 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in positive regulation of locomotion involved in locomotory behavior; positive regulation of macromolecule metabolic process; and positive regulation of protein localization to cell surface. Expressed in head neurons; tail neurons; and ventral nerve cord. Is an ortholog of human DMWD (DM1 locus, WD repeat containing) and WDR20 (WD repeat domain 20).
ptr-20 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in molting cycle. Acts upstream of or within nematode male tail mating organ morphogenesis. Predicted to be located in cytoplasmic vesicle membrane and plasma membrane. Human ortholog(s) of this gene implicated in autistic disorder. Is an ortholog of human PTCHD1 (patched domain containing 1) and PTCHD4 (patched domain containing 4).
msn [Search on AGR]
Drosophila melanogaster misshapen (msn) encodes a Sterile 20 MAP kinase kinase kinase.
wdr-62 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable kinase activity. Predicted to be involved in centriole replication. Predicted to be located in mitotic spindle. Human ortholog(s) of this gene implicated in several diseases, including nephronophthisis 20; polymicrogyria; and primary autosomal recessive microcephaly 2 with or without cortical malformations. Is an ortholog of human WDR62 (WD repeat domain 62).
acdh-13 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable acyl-CoA dehydrogenase activity. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 20. Is an ortholog of human ACAD9 (acyl-CoA dehydrogenase family member 9).
nonu-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable endonuclease activity. Human ortholog(s) of this gene implicated in several diseases, including alcoholic liver cirrhosis; hypomyelinating leukodystrophy 20; and restless legs syndrome. Is an ortholog of several human genes including CNP (2',3'-cyclic nucleotide 3' phosphodiesterase); N4BP2 (NEDD4 binding protein 2); and N4BP2L2 (NEDD4 binding protein 2 like 2).
tmem-231 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in non-motile cilium assembly. Located in ciliary transition zone. Expressed in amphid neurons; ciliated neurons; inner labial neurons; outer labial neurons; and phasmid neurons. Used to study Meckel syndrome and orofaciodigital syndrome. Human ortholog(s) of this gene implicated in Joubert syndrome 20 and Meckel syndrome. Is an ortholog of human TMEM231 (transmembrane protein 231).
dpy-13 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be a structural constituent of cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle. Located in collagen and cuticulin-based cuticle extracellular matrix.
rps-22 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be a structural constituent of ribosome. Involved in determination of adult lifespan. Predicted to be located in ribosome. Predicted to be part of cytosolic small ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 20. Is an ortholog of human RPS15A (ribosomal protein S15a).
fbxb-20 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enriched in PLML; PLMR; and pharyngeal muscle cell based on tiling array and single-cell RNA-seq studies. Is affected by several genes including
daf-2;
rrf-3; and
eat-2 based on tiling array; microarray; and RNA-seq studies. Is affected by twelve chemicals including hydrogen sulfide; methylmercuric chloride; and multi-walled carbon nanotube based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: F-box associated domain, type 2 and F-box associated.
F32B4.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable mitochondrion targeting sequence binding activity. Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix and tRNA import into mitochondrion. Predicted to be located in mitochondrial outer membrane. Predicted to be part of mitochondrial outer membrane translocase complex. Is an ortholog of human TOMM20L (translocase of outer mitochondrial membrane 20 like).
vars-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable valine-tRNA ligase activity. Predicted to be involved in valyl-tRNA aminoacylation. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 20. Is an ortholog of human VARS2 (valyl-tRNA synthetase 2, mitochondrial).
tomm-20 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable mitochondrion targeting sequence binding activity. Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix and tRNA import into mitochondrion. Predicted to be located in mitochondrial outer membrane. Predicted to be part of mitochondrial outer membrane translocase complex. Is an ortholog of human TOMM20 (translocase of outer mitochondrial membrane 20).
PPA39380 [Browse genome (BioProject PRJNA12644)] [Search on AGR]
Pristionchus pacificus Is predicted to encode a protein with the following domains: BTB/POZ domain; Protein SUP-1-like; MATH/TRAF domain; MATH domain; SKP1/BTB/POZ domain superfamily; TRAF-like; and Protein of unknown function (DUF2650).
Il20ra [Search on AGR]
Homo sapiens This gene encodes a member of the type II cytokine receptor family. The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. This gene and interleukin 20 receptor beta are highly expressed in skin, and are upregulated in psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]