mpk-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables MAP kinase activity. Involved in several processes, including determination of adult lifespan; intracellular signal transduction; and positive regulation of nitrogen compound metabolic process. Located in cytoplasm and nucleus. Expressed in F cell; U cell; germ line; gonad; and oocyte. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Noonan syndrome 13; carcinoma (multiple); and childhood pilocytic astrocytoma. Is an ortholog of human MAPK1 (mitogen-activated protein kinase 1).
sur-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in several processes, including cellular response to zinc ion; muscle cell cellular homeostasis; and positive regulation of Ras protein signal transduction. Located in endoplasmic reticulum membrane. Expressed in several structures, including hypodermis; muscle cell; pharynx; tail; and vulva.
sur-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable protein phosphatase regulator activity. Involved in embryo development; nematode larval development; and positive regulation of vulval development. Predicted to be located in cytosol. Predicted to be part of protein phosphatase type 2A complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; spinocerebellar ataxia type 12; and systemic lupus erythematosus. Is an ortholog of human PPP2R2A (protein phosphatase 2 regulatory subunit Balpha) and PPP2R2D (protein phosphatase 2 regulatory subunit Bdelta).
sur-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable acetoacetate-CoA ligase activity. Predicted to be involved in fatty acid metabolic process. Predicted to be located in cytoplasm and nucleus. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; gonad; hypodermal cell; and somatic cell. Is an ortholog of human AACS (acetoacetyl-CoA synthetase).
sur-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in defense response to Gram-positive bacterium; regulation of protein catabolic process; and regulation of transcription by RNA polymerase II. Part of mediator complex. Expressed in several structures, including P1.p; P2.p; P5.ppp; P7.paa; and vulval cell. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 18. Is an ortholog of human MED23 (mediator complex subunit 23).
Sur [Search on AGR]
Drosophila melanogaster Sulfonylurea receptor (Sur) encodes a predicted ATP-sensitive K[+] channel expressed almost exclusively in the embryonic heart. Sur loss in the adult heart causes increased oxidative stress and pacing-induced heart failure.
haly-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable histidine ammonia-lyase activity. Involved in histidine catabolic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in histidinemia. Is an ortholog of human HAL (histidine ammonia-lyase).
dsl-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables Notch binding activity. Predicted to be involved in cell fate specification. Predicted to be located in extracellular region and membrane. Expressed in several structures, including P6.paa; P6.pap; P6.ppa; P6.ppp; and vulval cell.
Bma-sur-2 [Browse genome (BioProject PRJNA10729)] [Search on AGR]
Brugia malayi Predicted to be involved in intracellular signal transduction. Is an ortholog of C. elegans
sur-2. In C. elegans,
sur-2 is involved in defense response to Gram-positive bacterium; regulation of protein catabolic process; and regulation of transcription by RNA polymerase II.
Cjp-sur-6 [Browse genome (BioProject PRJNA12591)] [Search on AGR]
Caenorhabditis japonica Predicted to enable protein phosphatase regulator activity. Predicted to be part of protein phosphatase type 2A complex. Is an ortholog of C. elegans
sur-6. In C. elegans,
sur-6 is involved in embryo development; nematode larval development; and positive regulation of vulval development.
SRAE_X000127600 [Browse genome (BioProject PRJEB125)] [Search on AGR]
Strongyloides ratti Predicted to enable protein phosphatase regulator activity. Predicted to be part of protein phosphatase type 2A complex. Is an ortholog of C. elegans
sur-6. In C. elegans,
sur-6 is involved in embryo development; nematode larval development; and positive regulation of vulval development.
OVOC11899 [Browse genome (BioProject PRJEB513)] [Search on AGR]
Onchocerca volvulus Predicted to enable protein phosphatase regulator activity. Predicted to be part of protein phosphatase type 2A complex. Is an ortholog of C. elegans
sur-6. In C. elegans,
sur-6 is involved in embryo development; nematode larval development; and positive regulation of vulval development.
Ppa-sur-6 [Browse genome (BioProject PRJNA12644)] [Search on AGR]
Pristionchus pacificus Predicted to enable protein phosphatase regulator activity. Predicted to be part of protein phosphatase type 2A complex. Is an ortholog of C. elegans
sur-6. In C. elegans,
sur-6 is involved in embryo development; nematode larval development; and positive regulation of vulval development.
SRAE_2000241800 [Browse genome (BioProject PRJEB125)] [Search on AGR]
Strongyloides ratti Predicted to enable protein phosphatase regulator activity. Predicted to be part of protein phosphatase type 2A complex. Is an ortholog of C. elegans
sur-6. In C. elegans,
sur-6 is involved in embryo development; nematode larval development; and positive regulation of vulval development.
Cbn-sur-6.2 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Predicted to enable protein phosphatase regulator activity. Predicted to be part of protein phosphatase type 2A complex. Is an ortholog of C. elegans
sur-6. In C. elegans,
sur-6 is involved in embryo development; nematode larval development; and positive regulation of vulval development.
Cbr-sur-6 [Browse genome (BioProject PRJNA10731)] [Search on AGR]
Caenorhabditis briggsae Predicted to enable protein phosphatase regulator activity. Predicted to be part of protein phosphatase type 2A complex. Is an ortholog of C. elegans
sur-6. In C. elegans,
sur-6 is involved in embryo development; nematode larval development; and positive regulation of vulval development.
Bma-sur-6 [Browse genome (BioProject PRJNA10729)] [Search on AGR]
Brugia malayi Predicted to enable protein phosphatase regulator activity. Predicted to be part of protein phosphatase type 2A complex. Is an ortholog of C. elegans
sur-6. In C. elegans,
sur-6 is involved in embryo development; nematode larval development; and positive regulation of vulval development.
Cbn-sur-6.1 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Predicted to enable protein phosphatase regulator activity. Predicted to be part of protein phosphatase type 2A complex. Is an ortholog of C. elegans
sur-6. In C. elegans,
sur-6 is involved in embryo development; nematode larval development; and positive regulation of vulval development.
Cre-sur-6 [Browse genome (BioProject PRJNA577507)] [Search on AGR]
Caenorhabditis remanei Predicted to enable protein phosphatase regulator activity. Predicted to be part of protein phosphatase type 2A complex. Is an ortholog of C. elegans
sur-6. In C. elegans,
sur-6 is involved in embryo development; nematode larval development; and positive regulation of vulval development.
TMUE_2000009360 [Browse genome (BioProject PRJEB126)] [Search on AGR]
Trichuris muris Predicted to enable protein phosphatase regulator activity. Predicted to be part of protein phosphatase type 2A complex. Is an ortholog of C. elegans
sur-6. In C. elegans,
sur-6 is involved in embryo development; nematode larval development; and positive regulation of vulval development.
cdf-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables protein kinase binding activity. Involved in cellular response to zinc ion; positive regulation of Ras protein signal transduction; and positive regulation of vulval development. Located in basolateral plasma membrane. Expressed in several structures, including P5.ppp; P7.paa; rectal valve cell; vulval cell; and vulval muscle. Human ortholog(s) of this gene implicated in hypermanganesemia with dystonia 1. Is an ortholog of human SLC30A1 (solute carrier family 30 member 1).
Cjp-sur-2.2 [Browse genome (BioProject PRJNA12591)] [Search on AGR]
Caenorhabditis japonica Is predicted to encode a protein with the following domains: Mediator complex, subunit Med23 and Mediator complex subunit 23. Is an ortholog of C. elegans
sur-2. In C. elegans,
sur-2 is involved in defense response to Gram-positive bacterium; regulation of protein catabolic process; and regulation of transcription by RNA polymerase II.
Ppa-sur-2 [Browse genome (BioProject PRJNA12644)] [Search on AGR]
Pristionchus pacificus Is predicted to encode a protein with the following domains: Mediator complex, subunit Med23 and Mediator complex subunit 23. Is an ortholog of C. elegans
sur-2. In C. elegans,
sur-2 is involved in defense response to Gram-positive bacterium; regulation of protein catabolic process; and regulation of transcription by RNA polymerase II.
CBN18679 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Is predicted to encode a protein with the following domains: Mediator complex, subunit Med23 and Mediator complex subunit 23. Is an ortholog of C. elegans
sur-2. In C. elegans,
sur-2 is involved in defense response to Gram-positive bacterium; regulation of protein catabolic process; and regulation of transcription by RNA polymerase II.
Cbn-sur-2 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Is predicted to encode a protein with the following domains: Mediator complex, subunit Med23 and Mediator complex subunit 23. Is an ortholog of C. elegans
sur-2. In C. elegans,
sur-2 is involved in defense response to Gram-positive bacterium; regulation of protein catabolic process; and regulation of transcription by RNA polymerase II.
TMUE_1000003087 [Browse genome (BioProject PRJEB126)] [Search on AGR]
Trichuris muris Is predicted to encode a protein with the following domains: Mediator complex, subunit Med23 and Mediator complex subunit 23. Is an ortholog of C. elegans
sur-2. In C. elegans,
sur-2 is involved in defense response to Gram-positive bacterium; regulation of protein catabolic process; and regulation of transcription by RNA polymerase II.
CBN21546 [Browse genome (BioProject PRJNA20035)] [Search on AGR]
Caenorhabditis brenneri Is predicted to encode a protein with the following domains: Mediator complex, subunit Med23 and Mediator complex subunit 23. Is an ortholog of C. elegans
sur-2. In C. elegans,
sur-2 is involved in defense response to Gram-positive bacterium; regulation of protein catabolic process; and regulation of transcription by RNA polymerase II.
Cre-sur-2 [Browse genome (BioProject PRJNA577507)] [Search on AGR]
Caenorhabditis remanei Is predicted to encode a protein with the following domains: Mediator complex, subunit Med23 and Mediator complex subunit 23. Is an ortholog of C. elegans
sur-2. In C. elegans,
sur-2 is involved in defense response to Gram-positive bacterium; regulation of protein catabolic process; and regulation of transcription by RNA polymerase II.
SRAE_2000237600 [Browse genome (BioProject PRJEB125)] [Search on AGR]
Strongyloides ratti Is predicted to encode a protein with the following domains: Mediator complex, subunit Med23 and Mediator complex subunit 23. Is an ortholog of C. elegans
sur-2. In C. elegans,
sur-2 is involved in defense response to Gram-positive bacterium; regulation of protein catabolic process; and regulation of transcription by RNA polymerase II.
Cbr-sur-2 [Browse genome (BioProject PRJNA10731)] [Search on AGR]
Caenorhabditis briggsae Is predicted to encode a protein with the following domains: Mediator complex, subunit Med23 and Mediator complex subunit 23. Is an ortholog of C. elegans
sur-2. In C. elegans,
sur-2 is involved in defense response to Gram-positive bacterium; regulation of protein catabolic process; and regulation of transcription by RNA polymerase II.
Cjp-sur-2.1 [Browse genome (BioProject PRJNA12591)] [Search on AGR]
Caenorhabditis japonica Is predicted to encode a protein with the following domains: Mediator complex, subunit Med23 and Mediator complex subunit 23. Is an ortholog of C. elegans
sur-2. In C. elegans,
sur-2 is involved in defense response to Gram-positive bacterium; regulation of protein catabolic process; and regulation of transcription by RNA polymerase II.
Ovo-sur-2 [Browse genome (BioProject PRJEB513)] [Search on AGR]
Onchocerca volvulus Is predicted to encode a protein with the following domains: Mediator complex, subunit Med23 and Mediator complex subunit 23. Is an ortholog of C. elegans
sur-2. In C. elegans,
sur-2 is involved in defense response to Gram-positive bacterium; regulation of protein catabolic process; and regulation of transcription by RNA polymerase II.
dep-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables phosphatase activity. Involved in positive regulation of vulval development and vulval cell fate specification. Predicted to be located in membrane. Expressed in several structures, including P5.paa; P5.pap; P5.ppa; P5.ppp; and P7.paa. Human ortholog(s) of this gene implicated in several diseases, including breast angiosarcoma; carcinoma (multiple); and central nervous system cancer (multiple). Is an ortholog of human PTPRB (protein tyrosine phosphatase receptor type B).
apx-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable Notch binding activity. Involved in several processes, including lateral inhibition; regulation of germ cell proliferation; and regulation of vulval development. Predicted to be located in cytoplasm; nucleus; and plasma membrane. Expressed in several structures, including P6.paa; P6.pap; P6.ppa; non-striated muscle; and vulva. Human ortholog(s) of this gene implicated in spondylocostal dysostosis 1. Is an ortholog of human DLL3 (delta like canonical Notch ligand 3).
cdf-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable zinc ion transmembrane transporter activity. Involved in cellular response to zinc ion and zinc ion transmembrane transport. Located in gut granule membrane. Expressed in intestine. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is an ortholog of human SLC30A8 (solute carrier family 30 member 8).
OVOC7029 [Browse genome (BioProject PRJEB513)] [Search on AGR]
Onchocerca volvulus Predicted to enable catalytic activity and extracellular ligand-gated monoatomic ion channel activity. Predicted to be involved in biosynthetic process and monoatomic ion transport. Predicted to be located in membrane. Is an ortholog of C. elegans W09D6.1 and
sur-5.
lag-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables Notch binding activity. Involved in several processes, including maintenance of dauer; regulation of basement membrane organization; and regulation of cell population proliferation. Located in cell projection membrane and neuronal cell body membrane. Expressed in several structures, including distal tip cell; germ line; hypodermal cell; neurons; and vulval cell.
let-92 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables DEAD/H-box RNA helicase binding activity. Involved in organelle organization. Located in several cellular components, including axonal growth cone; centrosome; and neuronal cell body. Part of protein phosphatase type 2A complex. Human ortholog(s) of this gene implicated in Parkinson's disease; congestive heart failure; and prostate cancer. Is an ortholog of human PPP2CA (protein phosphatase 2 catalytic subunit alpha) and PPP2CB (protein phosphatase 2 catalytic subunit beta).
ify-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables protease binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including cortical granule exocytosis; nuclear division; and protein stabilization. Located in condensed chromosome; cytoplasm; and spindle microtubule. Expressed in germ cell.
T04F3.1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable transaminase activity. Predicted to be involved in amino acid metabolic process. Is an ortholog of human ACCS (1-aminocyclopropane-1-carboxylate synthase homolog (inactive)) and ACCSL (1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like).
brd-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables ubiquitin protein ligase activity. Involved in DNA repair and protein ubiquitination. Part of BRCA1-BARD1 complex. Human ortholog(s) of this gene implicated in breast cancer and ovarian cancer. Is an ortholog of human BARD1 (BRCA1 associated RING domain 1).
ape-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables
p53 binding activity. Involved in negative regulation of apoptotic process. Predicted to be located in cytoplasm and nucleus. Expressed in several structures, including neurons and ventral nerve cord. Is an ortholog of human PPP1R13B (protein phosphatase 1 regulatory subunit 13B) and TP53BP2 (tumor protein
p53 binding protein 2).
sna-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable transcription coactivator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of core mediator complex and mediator complex. Expressed in several structures, including germ cell and somatic cell.
asd-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables single-stranded RNA binding activity. Predicted to be involved in nervous system development and regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in cytoplasm and nucleus. Expressed in body wall musculature; intestine; nervous system; and vulval muscle. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; hypoplastic left heart syndrome; myotonic dystrophy type 1; and type 2 diabetes mellitus. Is an ortholog of human RBFOX1 (RNA binding
fox-1 homolog 1); RBFOX2 (RNA binding
fox-1 homolog 2); and RBFOX3 (RNA binding
fox-1 homolog 3).
mpz-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables GTPase activating protein binding activity. Located in axon. Expressed in body wall musculature; nerve ring; neurons; and vulval muscle. Human ortholog(s) of this gene implicated in hydrocephalus. Is an ortholog of human MPDZ (multiple PDZ domain crumbs cell polarity complex component) and PATJ (PATJ crumbs cell polarity complex component).
git-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable GTPase activator activity and small GTPase binding activity. Involved in gonad morphogenesis and inductive cell migration. Located in hemidesmosome and presynaptic active zone. Human ortholog(s) of this gene implicated in Huntington's disease and attention deficit hyperactivity disorder. Is an ortholog of human GIT2 (GIT ArfGAP 2).