Predicted to enable D-erythro-sphingosine kinase activity and acetyltransferase activity. Involved in mitochondrial unfolded protein response; positive regulation of acetylcholine secretion, neurotransmission; and regulation of locomotion. Located in several cellular components, including mitochondrion; neuronal cell body; and presynaptic periactive zone. Expressed in several structures, including body wall musculature; excretory canal; intestine; linker cell; and neurons. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is an ortholog of human SPHK1 (sphingosine kinase 1) and SPHK2 (sphingosine kinase 2).
Predicted to enable kinase activity. Is an ortholog of C. elegans sphk-1. In C. elegans, sphk-1 is involved in mitochondrial unfolded protein response; positive regulation of acetylcholine secretion, neurotransmission; and regulation of locomotion.
Predicted to enable kinase activity. Is an ortholog of C. elegans sphk-1. In C. elegans, sphk-1 is involved in mitochondrial unfolded protein response; positive regulation of acetylcholine secretion, neurotransmission; and regulation of locomotion.
Predicted to be located in endoplasmic reticulum membrane. Expressed in head; neurons; spermatheca; and vulva. Is an ortholog of human TMEM41B (transmembrane protein 41B).
Predicted to be involved in negative regulation of apoptotic signaling pathway. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and membrane. Expressed in excretory system; neurons; and pharyngeal muscle cell. Is an ortholog of human GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1).
Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Predicted to be involved in modification-dependent protein catabolic process and protein ubiquitination.
Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Predicted to be involved in modification-dependent protein catabolic process and protein ubiquitination.
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly. Predicted to be located in actin cytoskeleton and plasma membrane. Is an ortholog of human LIMA1 (LIM domain and actin binding 1).