Involved in determination of adult lifespan and methylglyoxal metabolic process. Expressed widely. Is an ortholog of human GLOD4 (glyoxalase domain containing 4).
Predicted to be located in endoplasmic reticulum membrane. Expressed in head; neurons; spermatheca; and vulva. Is an ortholog of human TMEM41B (transmembrane protein 41B).
Is affected by several genes including daf-12; eat-2; and glp-4 based on tiling array and RNA-seq studies. Is affected by multi-walled carbon nanotube and graphene oxide based on RNA-seq studies.
Predicted to be involved in negative regulation of apoptotic signaling pathway. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and membrane. Expressed in excretory system; neurons; and pharyngeal muscle cell. Is an ortholog of human GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1).
Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in positive regulation of transcription elongation by RNA polymerase II and recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex. Predicted to be located in nucleus. Predicted to be part of Cdc73/Paf1 complex. Human ortholog(s) of this gene implicated in carcinoma (multiple); colorectal cancer; and hyperparathyroidism. Is an ortholog of human CDC73 (cell division cycle 73).
Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Expressed in seam cell.
Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in several processes, including cellular component organization; modulation of chemical synaptic transmission; and positive regulation of protein localization to synapse. Located in axon; cytoplasm; and muscle cell projection. Expressed in several structures, including egg-laying apparatus; hermaphrodite gonad; lumbar ganglion; neurons; and tail hypodermis. Used to study epilepsy. Human ortholog(s) of this gene implicated in artery disease (multiple); autosomal dominant intellectual developmental disorder 44; and cerebral infarction. Is an ortholog of human KALRN (kalirin RhoGEF kinase) and TRIO (trio Rho guanine nucleotide exchange factor).
Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Predicted to be involved in modification-dependent protein catabolic process and protein ubiquitination.