Expressed in hypodermis and intestine. Is predicted to encode a protein with the following domains: Up-Regulated in long-lived daf-2 and Up-regulated in Daf-2.
Enables histone H3K27me2/H3K27me3 demethylase activity; histone H3K9 demethylase activity; and histone binding activity. Involved in mitochondrial unfolded protein response. Located in nucleus. Expressed in several structures, including germ cell; hypodermis; muscle cell; and neurons. Used to study syndromic X-linked intellectual disability. Human ortholog(s) of this gene implicated in melanoma; prostate cancer; and syndromic X-linked intellectual disability Siderius type. Is an ortholog of human KDM7A (lysine demethylase 7A).
Enables cyclin-dependent protein serine/threonine kinase activator activity. Involved in embryo development. Located in nucleus. Expressed in several structures, including head. Is an ortholog of human CCNT1 (cyclin T1).
Predicted to enable myo-inositol:proton symporter activity. Predicted to be involved in myo-inositol transport and transmembrane transport. Located in apical plasma membrane and basal plasma membrane. Expressed in amphid sheath cell; excretory canal; and phasmid sheath cell. Is an ortholog of human SLC2A13 (solute carrier family 2 member 13).
Expressed in hypodermis and intestine. Is predicted to encode a protein with the following domains: Up-Regulated in long-lived daf-2 and Up-regulated in Daf-2.
Predicted to enable several functions, including 6-phosphofructokinase activity; carbohydrate derivative binding activity; and identical protein binding activity. Predicted to be involved in canonical glycolysis; fructose 1,6-bisphosphate metabolic process; and fructose 6-phosphate metabolic process. Predicted to be located in cytoplasm. Predicted to be part of 6-phosphofructokinase complex. Human ortholog(s) of this gene implicated in glycogen storage disease VII. Is an ortholog of human PFKL (phosphofructokinase, liver type); PFKM (phosphofructokinase, muscle); and PFKP (phosphofructokinase, platelet).
Predicted to enable ATP:ADP antiporter activity. Predicted to be involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Located in mitochondrion. Expressed in body wall musculature; head neurons; intestine; pharynx; and seam cell. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 2; facioscapulohumeral muscular dystrophy; intrinsic cardiomyopathy (multiple); and mitochondrial DNA depletion syndrome (multiple). Is an ortholog of human SLC25A4 (solute carrier family 25 member 4); SLC25A5 (solute carrier family 25 member 5); and SLC25A6 (solute carrier family 25 member 6).