clh-4::GFP express in the excretory cell of control animals. In contrast, there is a consistent and complete loss of GFP expression in the excretory cell of ceh-6(RNAi) treated animals for clh-4::GFP.
VPS-39 is a 923 amino acid protein that contains an amino terminal citron homology domain (CNH) and a carboxyl-terminal clathrin heavy chain repeat (CLH) motif. C-terminal region with CLH interacts with CUTI-1 in yeast two-hybrid experiments.
VPS-39 is a 923 amino acid protein that contains an amino terminal citron homology domain (CNH) and a carboxyl-terminal clathrin heavy chain repeat (CLH) motif. C-terminal region with CLH interacts with CUTI-1 in yeast two-hybrid experiments.
"The Caenorhabditis elegans WNK-like kinase WNK-1 interacts with and phosphorylates germinal centre kinase(GCK)-3 - STE20-like kinase - which is known to inactivate CLH-3, a CIC chloride channel."