"we used reporter transgenic worms in which GFP expression is controlled by the CRE reporter (pCRE::GFP) (Kimura et al., 2002). In untrained worms, CREB activity is barely detectible (Figure 4A). After spaced butanone/food long-term memory training, we observed fluorescence in two sets of neurons (Figures 4A and 4B)... Many CREB/LTAM-induced genes that are required for longterm memory (Figure 3) are not detected in AIM neurons (Figure S7). Rather, their expression is prominent in neurons of the nerve ring, or in socket cell glia in the case of F21G4.1, or both (
ins-22). Knockdown of F21G4.1 blocks 16 hr memory (Figure 3G), suggesting that socket cell glia may play a role in LTAM. The PQN-73 prion-like protein is expressed in the arcade cells and is also required for LTAM (Figures S7 and 3G)."